Lactones
eMolecules 622381-67-3 | tert-Butyl 4-[4-(hydroxymethyl)benzyl]tetrahydro-1(2H)-pyrazinecarboxylate | Combi-Blocks, Inc. | MFCD06658975 | 306.406 | C17H26N2O3 | 95.000 | CC(C)(C)OC(=O)N1CCN(Cc2ccc(CO)cc2)CC1 | 1g | 801110541
tert-Butyl 4-[4-(hydroxymethyl)benzyl]tetrahydro-1(2H)-pyrazinecarboxylate | Combi-Blocks, Inc. | 622381-67-3 | MFCD06658975 | 306.406 | C17H26N2O3 | 95.000 | CC(C)(C)OC(=O)N1CCN(Cc2ccc(CO)cc2)CC1 | 1g | 801110541
Aobchem 2-Bromo-3-methyl-5-(hydroxymethyl)pyridine | ≥97% | CAS 1310416-58-0 | C7H8BrNO | 10g
2-Bromo-3-methyl-5-(hydroxymethyl)pyridine | ≥97% | CAS 1310416-58-0 | C7H8BrNO | 10g
Medchemexpress LLC Fc gamma RIIA/CD32a protein, rhesus macaque, recombinant (His tag) | >95.0% | 1 MG
Recombinant extracellular domain of rhesus macaque Fc gamma receptor IIa (CD32a) produced in HEK293 cells and supplied as a lyophilized His-tagged protein for biochemical and immunological assays involving Fc receptor interactions.
- Recombinant protein expressed in HEK293 cells.
- Contains a C-terminal His tag for detection and purification.
- Lyophilized powder formulation for storage stability.
- Purity >95.0% by reducing SDS-PAGE.
- Low endotoxin level <1 EU/μg suitable for sensitive assays.
- Available in a 1 mg size for assay-scale experiments.
eMolecules 344884-10-2 | TERT-BUTYL 2-(HYDROXYMETHYL)-5-OXOPYRROLIDINE-1-CARBOXYLATE | AstaTech | MFCD24532043 | 215.249 | C10H17NO4 | 95.000 | CC(C)(C)OC(=O)N1C(CO)CCC1=O | 0.25g | 386413500
TERT-BUTYL 2-(HYDROXYMETHYL)-5-OXOPYRROLIDINE-1-CARBOXYLATE | AstaTech | 344884-10-2 | MFCD24532043 | 215.249 | C10H17NO4 | 95.000 | CC(C)(C)OC(=O)N1C(CO)CCC1=O | 0.25g | 386413500
Medchemexpress LLC gamma Catenin Antibody (YA420) | 82 kDa | 50 UL
The gamma Catenin Antibody (YA420) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically targeting gamma Catenin. This protein is a crucial cytoplasmic component found in submembranous plaques of both desmosomes and intermediate junctions, forming distinct complexes with cadherins. As a member of the catenin family, it features a characteristic armadillo repeat motif. Mutations in the gene encoding gamma Catenin have been linked to Naxos disease.
- Suitable for Western blot (WB) applications with a dilution ratio of 1:500-1:1000.
- Applicable for immunohistochemistry-paraffin (IHC-P) at a dilution of 1:50-1:100.
- Supports immunohistochemistry-frozen (IHC-F) with a dilution range of 1:50-1:100.
- Compatible with immunocytochemistry/immunofluorescence (ICC/IF) at 1:50-1:200 dilution.
- Can be used for multiplex immunohistochemistry (mIHC) with a 1:300 dilution.
Medchemexpress LLC Ppar gamma protein, human (C-His, solution) | >90.0% | 50UG
Recombinant fragment of human peroxisome proliferator-activated receptor gamma representing the ligand-binding domain (residues D238-D503). Supplied as a C-terminal His-tagged solution expressed in E. coli and formulated for biochemical and biophysical assays, this product offers high purity and low endotoxin suitable for binding, screening, and structural studies.
- Recombinant human PPARγ ligand-binding domain (residues D238-D503).
- C-terminal His tag for detection and purification.
- Expressed in E. coli and supplied as a 0.22 μm filtered solution.
- Formulated in 50 mM Tris, 300 mM NaCl, 500 mM arginine, pH 8.0, 10% glycerol.
- Approximate molecular weight 30 kDa.
- Purity greater than 90% by reducing SDS-PAGE.
- Endotoxin level <1 EU/μg (LAL method).
- Suitable for biochemical binding, ligand screening, and structural studies.
Chem-Impex International, Inc. Gibberellic acid | MFCD00079329 | 25G
Gibberellic acid, MFCD00079329, 25G
Chem-Impex International, Inc. Gibberellic acid | MFCD00079329 | 5G
Gibberellic acid, MFCD00079329, 5G
Medchemexpress LLC Butyrolactone 3 (MB-3) | 778649-18-6 | 99.6% | 10 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5, with an IC50 of 100 μM. It demonstrates high affinity for the Gcn5 enzyme, similar to its natural substrate, histone H3, and shows weak inhibition of CBP (IC50 = 0.5 mM). This compound is suitable for studies related to cancer, metabolic, autoimmune, and neurological diseases.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5
- High affinity for the Gcn5 enzyme
- Weak inhibition of CBP
- Can be used in studies of cancer, metabolic, autoimmune, and neurological diseases
Selleck Chemical LLC Butyrolactone 3-E1387-1MG
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50 100 M) which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate histone H3 Butyrolactone 3 shows weak inhibitory on CBP (IC50 0 5 mM) Butyrolactone 3 can be used in studies of cancer metabolic autoimmune and neurological diseases
Medchemexpress LLC Butyrolactone 3 (MB-3) | 778649-18-6 | 99.6% | 1 MG
Butyrolactone 3 (MB-3) is a specific small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM). It exhibits high affinity for the Gcn5 enzyme, comparable to its natural substrate, histone H3. It shows weak inhibition on CBP (IC50=0.5 mM) and can be used in studies of cancer, metabolic, autoimmune, and neurological diseases. This product is for research use only.
- Specific small-molecule inhibitor of histone acetyltransferase Gcn5 (IC50=100 μM).
- High affinity for the Gcn5 enzyme, comparable to histone H3.
- Weak inhibition on CBP (IC50=0.5 mM).
- Used in studies of cancer, metabolic, autoimmune, and neurological diseases.
- Purity of 99.58%.
- Molecular weight of 184.19.
- Chemical formula: C9H12O4.
- Solid, white to off-white appearance.
- Recommended storage for powder: -20°C for 3 years.
- Solutions are unstable; freshly prepared solutions are recommended.
AdipoGen Butyrolactone I
Chemical. CAS 87414-49-1. Formula C24H24O7. MW 424.5. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 CDC2, -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs. Inhibitor of alpha-glucosidases. Maturation inhibitor of sheep oocytes.
Apexbio Technology LLC Butyrolactone 3 778649-18-6 1mg
Butyrolactone 3 (CAS 778649-18-6) is a small-molecule inhibitor that targets the histone acetyltransferase Gcn5 a member of the GNAT family with specificity for histone H3 acetylation In vitro studies demonstrate that Butyrolactone 3 inhibits Gcn5 activity with an IC50 of 100 M while showing minimal inhibition of CBP The binding affinity of Butyrolactone 3 to Gcn5 is comparable to that of histone H3 and its inhibition is non-irreversible indicating it does not act via a Michael addition mechanism Structurally modification at position 2 has been suggested as a basis for structure activity relationship (SAR) studies Currently Butyrolactone 3 is utilized in preclinical research aimed at modulating Gcn5-mediated histone acetylation