Lactones
Apexbio Technology LLC Ribonic acid gamma lactone 5336-08-3 500mg
Ribonic acid gamma lactone (CAS 5336-08-3) is a small-molecule inhibitor targeting -galactosidase derived from Escherichia coli It is designed to inhibit enzyme activity thereby interfering with substrate hydrolysis in carbohydrate metabolic pathways Ribonic acid gamma lactone exerts its biological activity primarily through competitive binding to the active site of -galactosidase In in vitro studies ribonic acid gamma lactone demonstrates inhibitory activity with an inhibitory constant (Ki) of approximately 26 mM Based on these pharmacological properties ribonic acid gamma lactone holds research potential in studies examining enzyme-substrate interactions and carbohydrate metabolism mediated by bacterial -galactosidase
Medchemexpress LLC GA-017 | 2351906-74-4 | 99.0% | 343.38 | 1 ML
GA-017 is a potent and selective inhibitor of large tumor suppressor kinase 1/2 (LATS1/2), with IC50 values of 4.10 nM and 3.92 nM respectively. It acts as an activator of cell proliferation, promoting YAP/TAZ activation and nuclear translocation. This compound supports cell growth under 3D culture conditions and enhances the ex vivo formation of mouse intestinal organoids, and also suppresses cell death of HUVECs.
- Potent and selective LATS1/2 inhibitor
- Activator of cell proliferation
- Promotes YAP/TAZ activation and nuclear translocation
- Supports cell growth under 3D culture conditions
- Enhances ex vivo formation of mouse intestinal organoids
- Suppresses cell death of HUVECs and promotes cell growth
- Facilitates SKOV3 cell growth with an EC50 of 3.51 ± 0.26 μM
- Competitively inhibits LATS1 and 2 against ATP
TARGETMOL CHEMICALS INC gamma-Linolenic acid 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 200 mg and bulk. Please contact Fisher for quotes. gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown gamma-Linolenic Acid to have induced reactive oxygen species generation including lipid peroxidation, cell growth inhibition, and heme oxygenase-1 production for antioxidant protection against oxidative stress. Further experiments have noted that gamma-Linolenic acid inhibits inflammatory responses through inactivation of NFkB and activator protein-1 by suppressed oxidative stress. Purity 99.21%
Medchemexpress LLC BD-1008 dihydrobromide | 138356-09-9 | MFCD00209903 | 98.1% | 463.08 | C15H24Br2Cl2N2 | 10 MG
BD-1008 dihydrobromide is a sigma receptor antagonist provided as a solid for research use. It is intended for in vitro and preclinical pharmacology studies, with characterized purity, molecular weight, and available milligram-scale pack sizes.
- Provided as a solid suitable for storage and handling in research labs.
- High reported purity for reliable pharmacological testing.
- Supplied in small milligram pack sizes to support experimental dosing.
- Characterized molecular weight and formula facilitate analytical confirmation.
- Accompanied by safety and handling documentation for laboratory use.
eMolecules (S)-4-METHYL-3-(HYDROXYMETHYL)MORPHOLINE | 1620510-50-0 | MFCD26792482 | 1g
AstaTech | (S)-4-METHYL-3-(HYDROXYMETHYL)MORPHOLINE | 1g | 596576101 | 77628 | 97.000 | 1620510-50-0 | MFCD26792482 | 131.175 | C6H13NO2
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Medchemexpress LLC CWHM-1008 | 2362539-97-5 | 99.1% | 405.46 | 1 ML
CWHM-1008 is a potent and orally active antimalarial agent. It exhibits EC50 values of 46 nM against agent-sensitive Plasmodium falciparum 3D7 and 21 nM against drug-resistant Dd2 strains. It is for research use only.
- Potent and orally active antimalarial agent.
- Effective against both agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains.
Medchemexpress LLC Bd-1008 dihydrobromide | 138356-09-9 | MFCD00209903 | >95.0% | 463.08 g/mol | C15H24Br2Cl2N2 | 5 MG
BD-1008 dihydrobromide is the dihydrobromide salt of BD-1008, a selective sigma (σ) receptor antagonist supplied as a purified research reagent. It is intended for laboratory research use to study sigma receptor pharmacology, signaling pathways, and modulation of stimulant or neurotoxic effects in preclinical models.
- Selective sigma receptor antagonist activity
- Dihydrobromide salt form for improved handling and solubility
- High purity (≥95%) suitable for research applications
- Small milligram pack sizes for preclinical use (e.g., 1-10 mg)
- CAS number 138356-09-9 for unambiguous identification
- Molecular weight ≈463.08 g/mol (salt form)
Medchemexpress LLC Gamma-glutamylcysteine | 636-58-8 | 98.5% | 250.27 | 10 MG
Gamma-glutamylcysteine (γ-Glutamylcysteine) is a dipeptide containing cysteine and glutamic acid. It serves as a precursor to glutathione (GSH) and acts as a cofactor for glutathione peroxidase (GPx), helping to increase GSH levels in the body.
- Precursor to glutathione (GSH)
- Cofactor for glutathione peroxidase (GPx) to increase GSH levels
- Increases activity of antioxidant enzymes like superoxide dismutase (SOD)
- Leads to significant increases in total antioxidant capacity (TAC)
- Reduces GSSG/GSH ratio
- Upregulates anti-inflammatory cytokine IL-10
- Reduces pro-inflammatory cytokines such as TNF-α and IL-6
- Attenuates changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes
Medchemexpress LLC γ-D-glutamylglycine | 6729-55-1 | MFCD00063109 | 99.2% | 204.18 g/mol | C7H12N2O5 | 1 ML
gamma-DGG (γ-D-glutamylglycine) is a competitive AMPA receptor blocker supplied as a 10 mM aqueous solution (1 mL). It reversibly reduces AMPA receptor-mediated synaptic currents and is commonly used in electrophysiology and neuropharmacology studies.
- Competitive AMPA receptor blocker
- Reversible inhibition of AMPA receptor-mediated currents
- Provided as a 10 mM aqueous solution, 1 mL
- High purity (99.16% by HPLC)
- Molecular weight 204.18 g/mol
- Suitable for electrophysiology and synaptic physiology studies
Medchemexpress LLC Mevalonolactone | 19115-49-2 | MFCD01074894 | 98.0% | 130.14 g/mol | C6H10O3 | 5 MG
Mevalonolactone is a sesquiterpene lactone used in laboratory research as a calcineurin inhibitor. It has been reported to inhibit calcineurin in a p-Nitrophenyl phosphate assay with an IC50 of 134.29 μM. The material is supplied as a high-purity research chemical in small, mg-scale quantities for biochemical and cell-based studies.
- Displays calcineurin inhibitory activity (IC50 134.29 μM).
- High purity: 98.0%.
- Molecular weight: 130.14 g/mol.
- Chemical formula: C6H10O3.
- Supplied in multiple research-scale package sizes.
- Storage guidance for solvent solutions: -80°C (2 years) or -20°C (1 year).