Oxazinanes
Cayman Chemical O2545 hydrochloride
A potent water-soluble agonist of CB1 and CB2 receptors with Ki values of 1.5 and 0.32 nM, respectively; when dissolved in saline, is highly efficacious in mouse behavioral models when administered either intravenously or intracerebroventricularly
Cayman Chemical PropenylLNIO hydrochloride
A potent, selective iNOS inhibitor (Kis = 17, 10.3 and 58.2 µM for iNOS, nNOS, and eNOS, respectively, for initial rate binding kinetics); demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS (Kis = 0.56 and 6 µM, respectively)
Medchemexpress LLC Prexasertib dihydrochloride | 1234015-54-3 | MFCD25977016 | 99.7% | 10 MG
Prexasertib dihydrochloride is a selective, ATP-competitive CHK1 inhibitor used in preclinical research to probe checkpoint signaling, replication stress, and DNA damage-induced apoptosis. It is suitable for biochemical and cellular assays investigating antitumor mechanisms and pathway dependencies.
- High potency against CHK1 (Ki 0.9 nM; IC50 <1 nM).
- Also inhibits CHK2 and RSK1 at low nanomolar concentrations (CHK2 IC50 8 nM; RSK1 IC50 9 nM).
- Available as solid powder and as DMSO solutions for flexible assay formats.
- Reported high purity appropriate for preclinical studies.
- Useful for studies of DNA damage response, replication catastrophe, and apoptosis.
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Cayman Chemical FR122047 hydrochloride
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Cayman Chemical ClAmidine hydrochloride
A PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively); reduces ex vivo extracellular NET formation and increases survival in a mouse model of CLP-induced sepsis at 50 mg/kg; decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis
Cayman Chemical FR122047 hydrochloride
A selective COX-1 inhibitor (IC50 = 0.028 µM for the human enzyme); selective for COX-1 over COX-2 (IC50 = 65 µM); inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation in human platelet-rich plasma (IC50 = 180-200 nM); unlike aspirin, it does not induce gastric damage at 100 mg/kg, p.o.; has an anti-inflammatory effect in a rat models of collagen-induced arthritis
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Medchemexpress LLC CN128 hydrochloride | 1335282-05-7 | 98.2% | 10 MM 1 ML
CN128 hydrochloride is an orally active and selective iron chelator. It is used for the research of β-thalassemia.
- Orally active and selective iron chelator
- High selectivity for iron(III) over other metals
- Lacks genetic toxicity and is well-tolerated
- Exhibits good oral bioavailability
- Demonstrates good iron scavenging efficacy in rats
- Iron removal efficacies are dose-dependent
Sigma Aldrich Fine Chemicals Biosciences Prazosin hydrochloride 99.1G
Prazosin is a member of the class of adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.
Sigma Aldrich Fine Chemicals Biosciences TrizmaR hydrochloride reag25KG
Trizma(R) hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH SOLUTIONon.
Sigma Aldrich Fine Chemicals Biosciences Butan 3 one 2 yl butanoate5KG
Butan 3 one 2 yl butanoate5KG
Chem-Impex International, Inc. 4-(4-Bromophenyl)morpholine | MFCD04112483 | 25G
4-(4-Bromophenyl)morpholine, MFCD04112483, 25G
Selleck Chemical LLC N6F11-E1812-250MG
N6F11 is an inducer of ferroptosis N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4) resulting in proteasomal degradation