Oxazinanes
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.7% | 438.31 | 50 MG
Prexasertib dihydrochloride is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with potent anti-tumor activity. It causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis.
- Selective CHK1 inhibitor with Ki of 0.9 nM and IC50 of <1 nM
- Also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM)
- Causes double-stranded DNA breakage
- Induces replication catastrophe and apoptosis
- Demonstrates potent anti-tumor activity
- Inhibits MELK (IC50=38 nM), SIK (IC50=42 nM), BRSK2 (IC50=48 nM), and ARK5 (IC50=64 nM)
- Requires CDC25A and CDK2 to induce DNA damage
- Causes chromosomal fragmentation in HeLa cells
- Induces replication stress and depletes RPA2 available for DNA binding
- Shows tumor growth inhibition in xenografts
Medchemexpress LLC (6S,12aR)-Tadalafil (Tadalafil EP Impurity C) | 171596-28-4 | 99.5% | C22H19N3O4 | 50 MG
(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity. It is intended for research use only and is not sold to patients.
- Highly potent PDE5 inhibitor with an IC50 value of 5 nM.
- Has blood pressure lowering activity.
- Suitable for research applications only.
Medchemexpress LLC Sapropterin dihydrochloride | 69056-38-8 | 99.96% | C9H17Cl2N5O3 | 50 MG
Sapropterin dihydrochloride is an analytical standard used for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, helping to reduce blood phenylalanine concentrations. This compound is suitable for studying phenylketonuria (PKU). It is an analytical standard grade, commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Useful in the study of phenylketonuria (PKU)
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) | 1246298-60-1 | 99.0% | 634.11 | 1 MG
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) is a lipid molecule composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under conditions of obesity and type 2 diabetes (T2D). It cannot be further metabolized to more complex sphingolipid and is toxic when it accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro. This product is for research use only.
- Composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone.
- Accumulates under conditions of obesity and type 2 diabetes (T2D).
- Cannot be metabolized to more complex sphingolipids and is toxic upon accumulation.
- Increases in differentiated adipocytes in vitro.
- For research use only.
Medchemexpress LLC 7-Ethylcamptothecin | 78287-27-1 | 250 MG
7-Ethylcamptothecin is a derivative of Camptothecin and a DNA topoisomerase I inhibitor. It exhibits significant antitumor activity against tumor cells and serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. It is widely used in various tumor-related scientific studies.
- Functions as a DNA topoisomerase I inhibitor.
- Exhibits significant antitumor activity against tumor cells.
- Serves as a precursor for synthesizing 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds.
- Utilized in various tumor-related scientific studies.
- Starting material for developing E-ring modified water-soluble camptothecin derivatives.
- Appears as a light yellow to yellow solid.
- Has a purity of 99.58%.
Medchemexpress LLC Sapropterin dihydrochloride (standard) | 69056-38-8 | 100.0% | C9H17Cl2N5O3 | 5 MG
Sapropterin dihydrochloride (Standard) is the analytical standard of Sapropterin (dihydrochloride), intended for research and analytical applications. It functions as an orally active phenylalanine hydroxylase (PAH) cofactor, reducing blood phenylalanine concentrations, and is used in the study of phenylketonuria (PKU). Additionally, it can aggravate experimental autoimmune encephalomyelitis (EAE).
- Analytical standard for research and analytical applications
- Orally active phenylalanine hydroxylase (PAH) cofactor
- Reduces blood phenylalanine concentrations
- Used in the study of phenylketonuria (PKU)
- Can aggravate experimental autoimmune encephalomyelitis (EAE)
- Used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC (6S,12aR)-Tadalafil | 171596-28-4 | MFCD21363860 | 99.3% | 389.40 g·mol^-1 | C22H19N3O4 | 10 MG
(6S,12aR)-Tadalafil is a stereoisomeric impurity of tadalafil used as an analytical reference standard and research tool. It is a potent phosphodiesterase type 5 (PDE5) inhibitor (reported IC50 ≈ 5 nM) and is characterized for impurity profiling and pharmacological studies.
- High chemical purity (reported 99.3%).
- Well characterized: CAS 171596-28-4 and molecular formula C22H19N3O4.
- Suitable as a reference standard for analytical method development and impurity profiling.
- Useful for pharmacological research into PDE5 activity and blood-pressure effects.
- Available in small weighed packs for laboratory use (e.g., 10 MG).
Medchemexpress LLC ML241 hydrochloride | 2070015-13-1 | 99.8% | 408.92 | 1 ML
ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with an IC50 value of 100 nM. It is for research use only and not sold to patients.
- Potent p97 inhibitor with an IC50 value of 100 nM for p97 ATPase.
- Inhibits p97 competitively with respect to ATP with a Ki value of 0.35 μM.
- Shows no obvious inhibition of approximately 170 kinases tested at 20 μM.
- Stabilizes UbG76V-GFP with an IC50 of 3.5 μM.
- Cytotoxic to HCT15 and SW403 cells.
Medchemexpress LLC 1(2H)-Naphthalenone, 6-bromo-3,4-dihydro- | 66361-67-9 | 225.09 | 5 G
6-Bromo-3,4-dihydro-1(2H)-naphthalenone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is intended for research use only and not for sale to patients.
- Biochemical reagent for life science related research
- Appearance: off-white to pink solid
- Chemical formula: C10H9BrO
- Soluble in DMSO
- For research use only
- Powder storage: -20°C for 3 years; 4°C for 2 years
- In solvent storage: -80°C for 6 months; -20°C for 1 month