Oxazinanes
Medchemexpress LLC 8-Chloroisoquinolin-3(2H)-one | 51463-18-4 | 96.9% | 179.60 | 250 MG
8-Chloroisoquinolin-3(2H)-one is a chemical compound with a molecular weight of 179.60. It appears as a light yellow to yellow solid and has a purity of 96.93%. This product is suitable for various laboratory applications and research purposes.
- Consistent with structure based on analytical data
- High purity
- Supplied as a solid
- Intended for research use only
TARGETMOL CHEMICALS INC SB 258719 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5. purity: 98%
TARGETMOL CHEMICALS INC ZK-90055 HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. ZK-90055 hydrochloride is a (beta)2 adrenergic receptor agonist used to study asthma. purity: 99%
Medchemexpress LLC SAG (hydrochloride) | 2095432-58-7 | 99.91% | 1 MG
SAG hydrochloride is a potent Smoothened (Smo) receptor agonist with an EC50 of 3 nM and a Kd of 59 nM. It activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
- Induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
- Competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, showing a dissociation constant (Kd) of 59 nM.
- Increases SMO mRNA and protein expression in MDAMB231 cells.
- Increases CAXII mRNA expression in MDAMB231 cells under normoxic and hypoxic conditions.
- Increases MDAMB231 cell migration.
- Promotes osteogenesis and significantly increases BV/TV in CD-1 mice.
- Induces pre-axial polydactyly and increases Gli1 and Gli2 mRNA expression in the limb bud in mice.
Medchemexpress LLC Bomedemstat dihydrochloride | 99.6% | 592.54 | 100 MG
Bomedemstat dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation, altering gene expression. This compound exhibits anti-cancer activities by inhibiting cancer cell proliferation and inducing apoptosis.
- Increases H3K4 and H3K9 methylation
- Alters gene expression
- Inhibits cancer cell proliferation
- Induces apoptosis
Medchemexpress LLC Bomedemstat dihydrochloride | 99.55% | 592.54 | 25 MG
Bomedemstat dihydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation, which then alters gene expression. This compound exhibits anti-cancer activities by inhibiting cancer cell proliferation and inducing apoptosis, and is being investigated in multiple clinical trials.
- Selectively inhibits proliferation of Jak2V617F cells
- Induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner
- Leads to cell cycle arrest in SET-2 cells
- Normalizes or improves blood cell counts in Mx-Jak2V617F mice
- Reduces spleen volumes and restores normal splenic architecture in animal models
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Medchemexpress LLC C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) | 1246298-60-1 | 99.0% | 634.11 | 1 MG
C24:1 Dihydro 1-deoxyceramide (m18:0/24:1) is a lipid molecule composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under conditions of obesity and type 2 diabetes (T2D). It cannot be further metabolized to more complex sphingolipid and is toxic when it accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro. This product is for research use only.
- Composed of a long-chain fatty acid (24:1) and a 1-deoxysphingoid backbone.
- Accumulates under conditions of obesity and type 2 diabetes (T2D).
- Cannot be metabolized to more complex sphingolipids and is toxic upon accumulation.
- Increases in differentiated adipocytes in vitro.
- For research use only.
AdipoGen 5-DTAF hydrochloride
Chemical. CAS 21811-74-5. Formula C23H12Cl2N4O5 . HCl. MW 495.3 . 36.5. Synthetic. 5-DTAF is highly reactive with proteins. Unlike other reactive fluoresceins, 5-DTAF not only reacts with amino groups, but also reacts with thiol groups and even directly reacts with hydroxy groups such as polysaccharides and other alcohols in aqueous solution at pH above 9. Due to its high reactivity, 5-DTAF is also used to label carbohydrates. Spectral properties Abs/Em = 492/517 nm
eMolecules 90902-84-4 | 2,5-Dibromopyridin-3-amine | ChemScene | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 25g | 572179909
2,5-Dibromopyridin-3-amine | ChemScene | 90902-84-4 | MFCD09266224 | 251.909 | C5H4Br2N2 | 98.000 | Nc1cc(Br)cnc1Br | 25g | 572179909
Cayman Chemical Trimidox hydrochloride
A specific ribonucleotide reductase inhibitor; inhibits growth of human promyelocytic leukemia HL-60 cells (IC50 = 35 µM)
Apexbio Technology LLC Alosetron Hydrochloride 122852-69-1 10mM (in 1mL DMSO)
Alosetron Hydrochloride (CAS 122852-69-1) is a potent antagonist of the serotonin 5-HT3 receptor a ligand-gated ion channel implicated in the modulation of gastrointestinal function By selectively inhibiting 5-HT3 receptor-mediated signaling on enteric neurons Alosetron modulates visceral sensation and gastrointestinal motility This mechanism underlies its application in the study of serotonergic pathways involved in irritable bowel syndrome and related gastrointestinal disorders Alosetron serves as a valuable tool in biomedical research investigating the neurogastroenterology of serotonergic signaling and its role in gut-brain axis modulation
Cayman Chemical ClAmidine hydrochloride
A PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively); reduces ex vivo extracellular NET formation and increases survival in a mouse model of CLP-induced sepsis at 50 mg/kg; decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis
Cayman Chemical H89 hydrochloride
A potent, non-selective inhibitor of PKA with an IC50 value of 0.14 µM (Ki = 48 nM) that is widely used to disrupt PKA signaling; inhibits S6K1, MSK1, ROCK2, PKBa, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively
eMolecules 6968-35-0 | 7-Hydroxy-2,3-dihydro-1H-inden-1-one | ChemScene | MFCD01548387 | 148.161 | C9H8O2 | 98.000 | Oc1cccc2CCC(=O)c12 | 5g | 536852490
7-Hydroxy-2,3-dihydro-1H-inden-1-one | ChemScene | 6968-35-0 | MFCD01548387 | 148.161 | C9H8O2 | 98.000 | Oc1cccc2CCC(=O)c12 | 5g | 536852490