Piperidines
eMolecules 170921-49-0 | 4-Amino-1-benzylpiperidine-4-carboxamide | Combi-Blocks | MFCD00481001 | 233.315 | C13H19N3O | 97.000 | NC(=O)C1(N)CCN(Cc2ccccc2)CC1 | 1g | 117543515
4-Amino-1-benzylpiperidine-4-carboxamide | Combi-Blocks | 170921-49-0 | MFCD00481001 | 233.315 | C13H19N3O | 97.000 | NC(=O)C1(N)CCN(Cc2ccccc2)CC1 | 1g | 117543515
Medchemexpress LLC HY-14562 10mg Medchemexpress, TBPB CAS:634616-95-8 Purity:>98%
Medchemexpress, HY-14562 10mg TBPB CAS:634616-95-8 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 100 MG
(S,R)-GSK321 is the (S,R)-enantiomer of GSK321. It is a potent, selective mutant IDH1 inhibitor with IC50 values for R132G, R132C, R132H, and WT IDH1, and exhibits >100-fold selectivity over IDH2. (S,R)-GSK321 induces a decrease in intracellular 2-HG, abrogation of the myeloid differentiation block, and induction of granulocytic differentiation. It can be used for research of acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- Induces a decrease in intracellular 2-HG
- Abrogation of myeloid differentiation block
- Induction of granulocytic differentiation
- Useful in research for acute myeloid leukemia (AML) and other cancers
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Donepezil-d4 hydrochloride (E2020-d4) | 1219798-88-5 | 99.96% | C24H26D4ClNO3 | 1 MG
Donepezil-d4 (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE and exhibits neuroprotective effect on Aβ42 neurotoxicity.
- Acts as a reversible, selective AChE inhibitor.
- Demonstrates high selectivity for AChE over BuChE.
- Shows neuroprotective effects against Aβ42 neurotoxicity.
- Can be utilized as a tracer in research.
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes can influence pharmacokinetic and metabolic profiles of drugs.
eMolecules 117896-69-2 | 1-PHENYL-4-PIPERIDINOL | MFCD02093533 | 1g
Ambeed | Methyl 6-methylbenzo[d]thiazole-2-carboxylate | 100mg | 596569208 | A726755 | 1236115-18-6 | MFCD22373213 | 207.250 | C10H9NO2S
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Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 100 MG
GSK2879552 dihydrochloride is an orally active, selective, and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), which has potential antineoplastic activity. For research use only, it is not sold to patients.
- Orally active.
- Selective and irreversible inhibitor of LSD1/KDM1A.
- Exhibits potential antineoplastic activity.
- Inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuating stemness properties in vitro.
- Depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells in vitro.
- In vivo treatment with 1.5 mg/kg exhibits tumor growth inhibition in SCLC xenograft bearing mice.
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 50 MG
(R,R)-GSK321 is a potent inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor, being an isomer of GSK321 with some wild-type cross-reactivity.
- Potent WT IDH1 inhibitor
- IC50 value of 120 nM for WT IDH1
- Mutant R132H IDH1 inhibitor
- Decreases reductive glutaminolysis in A-498 cells
- For research use only
- Associated with cancer, cancer targeted therapy, and cancer metabolism research
- Classified as a metabolic enzyme/protease and isocitrate dehydrogenase (IDH) inhibitor
eMolecules 133696-21-6 | (2R,4R)-4-Hydroxypiperidine-2-carboxylic acid hydrochloride | 250mg
Ambeed | H-Asp(Oet)-OEt.HCl | 25g | 490524090 | A176340 | 16115-68-7 | MFCD00038910 | 225.670 | C8H16ClNO4
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