Piperidines
Medchemexpress LLC Animal-free IL-4 protein, pig (His) | 98.0% | 50UG
Recombinant porcine interleukin-4 (IL-4) supplied lyophilized and produced in E. coli. The protein contains a C-terminal 6xHis tag, has an approximate molecular weight of 15 kDa, and is ≥98.0% pure by reducing SDS-PAGE. Biological activity is validated (ED50 <0.6 ng/mL); reconstitute to 100-200 μg/mL and store lyophilized at -20 °C or aliquot and freeze at -20 °C/-80 °C for long-term storage.
- Recombinant porcine interleukin-4 in lyophilized form.
- C-terminal 6xHis tag for detection or purification.
- Produced in E. coli expression system.
- Approximate molecular weight of 15 kDa.
- Purity of 98.0% as determined by SDS-PAGE.
- Biologically active with ED50 <0.6 ng/mL in TF-1 assay.
- Formulated from 0.22 μm filtered PBS, pH 7.4.
- Stable lyophilized at -20 °C; aliquot and store at -20 °C/-80 °C after reconstitution.
Apexbio Technology LLC Autophagy/Cytotoxicity Dual Staining Kit (MDC/PI) 2000tests
Autophagy Cytotoxicity Dual Staining Kit MDC PI is a dual-fluorescent dye kit designed to assess autophagic activity and cytotoxicity in live cells It employs monodansylcadaverine (MDC) which labels autophagic vacuoles by associating with acidic lipid-containing compartments and propidium iodide (PI) which stains cells with compromised membranes indicative of severe injury or cell death Autophagy Cytotoxicity Dual Staining Kit MDC PI enables simultaneous detection of autophagy and cytotoxicity by fluorescent staining In cell-based studies it allows real-time visualization and analysis of autophagic activity and cell membrane integrity Based on these properties Autophagy Cytotoxicity Dual Staining Kit MDC PI is suitable for research applications in autophagy cytotoxicity pharmacological assessment and mechanistic studies related to disease models
Medchemexpress LLC HY-108642B 5mg Medchemexpress, AMG-548 (dihydrochloride) CAS: Purity:>98%
Medchemexpress, HY-108642B 5mg AMG-548 (diHCl) CAS: AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM). AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-114428 10mg Medchemexpress, P110δ-IN-1 CAS:1595129-71-7 Purity:>98%
Medchemexpress, HY-114428 10mg P110δ-IN-1 CAS:1595129-71-7 P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-W018061 5mg Medchemexpress, Traxoprodil CAS:134234-12-1 Purity:>98%
Medchemexpress, HY-W018061 5mg Traxoprodil CAS:134234-12-1 Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC 50 of 10 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Enzo Life Sciences Ceritinib (free base) (50mg). CAS: 1032900-25-6
Ceritinib is a selective inhibitor of ALK, a target found in metastatic non-small cell lung cancer. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
eMolecules Medchem Express / JNJ-42153605 / 5mg / 446268916 / HY-18162 / / 1254977-87-1 / MFCD22199231 / 400.449 / C22H23F3N4
Medchem Express / JNJ-42153605 / 5mg / 446268916 / HY-18162 / / 1254977-87-1 / MFCD22199231 / 400.449 / C22H23F3N4
Apexbio Technology LLC Piperine 94-62-2 200mg
Piperine (CAS 94-62-2) is an alkaloid primarily found in black pepper (Piper nigrum) that has demonstrated diverse pharmacological activities It modulates several signaling pathways including inhibition of drug-metabolizing enzymes such as CYP3A4 and P-glycoprotein and affects cellular processes through regulation of MAPK and Akt phosphorylation Piperine has been studied for its potential to enhance the bioavailability of various therapeutic agents and for its anti-inflammatory anti-tumor and neuroprotective properties This compound is utilized in biomedical research to investigate drug-drug interactions signal transduction mechanisms and its impact on cellular proliferation and apoptosis
Medchemexpress LLC HY-19650 5mg Medchemexpress, Pumosetrag Hydrochloride CAS:194093-42-0 Purity:>98%
Medchemexpress, HY-19650 5mg Pumosetrag Hydrochloride CAS:194093-42-0 Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC AT7519 HCl 5mg 902135-91-5
AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC [1,1'-Biphenyl]-4-carboxamide, 5'-[(5-amino-6-chloro-4-pyrimidinyl)amino]-2'-fluoro-N,N-dimethyl-4' | 2378768-36-4 | C24H27ClFN7O | 25 MG
DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. It selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.
- Orally active and potent WDR5-MLL1 inhibitor
- Has an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein
- Selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity
- Inhibits the proliferation of MLL translocation-harboring cells
- Useful for MLL fusion leukemia research
Medchemexpress LLC K-Ras-PDE -IN-1 100mg | 1841464-21-8 | 447.50 g·mol⁻1 | C25H26FN5O2 | 100 MG
K-Ras-PDEδ-IN-1 is a small-molecule, competitive inhibitor of PDEδ that binds the farnesyl-binding pocket with low-nanomolar affinity (Kd = 8 nM). It is supplied as a high-purity research chemical suitable for biochemical and cellular studies, with solubility and storage data provided for experimental use.
- Potent PDEδ inhibitor with a reported Kd of 8 nM.
- Binds the farnesyl-binding pocket of PDEδ.
- High purity (99.62%) suitable for research applications.
- Molecular formula C25H26FN5O2 and molecular weight 447.50 g·mol⁻1.
- Soluble in DMSO (12.5 mg/mL; sonication recommended).
- Stable as powder under low-temperature storage (powder: -20°C for 3 years; 4°C for 2 years).
- Available in a 100 MG pack size for laboratory use.