Piperidines
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 50 MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It induces apoptosis, increases the expression of cleaved PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- IC50s of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP
- Induces apoptosis and increases cleaved PARP expression
- Decreases expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.36% | 100 MG
(R,R)-GSK321 is a high-purity wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor. This compound acts as an isomer of GSK321, exhibiting potent inhibition with an IC50 value of 120 nM. It also functions as a mutant R132H IDH1 inhibitor with some wild-type cross-reactivity, making it a valuable tool for relevant research.
- Inhibits wild-type isocitrate dehydrogenase 1 (WT IDH1)
- IC50 value of 120 nM
- Functions as a mutant R132H IDH1 inhibitor
- High purity of 99.36%
- Appearance as a white to off-white solid
- For research use only
Medchemexpress LLC Roxatidine | 78273-80-0 | 98.25% | 306.40 | 50 MG
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride and an orally active histamine H2-receptor antagonist. It is an anti-ulcer agent that suppresses histamine release, inhibits proton secretion, and inhibits the production of VEGF-1. This agent also demonstrates anti-allergic inflammatory effects and is promising for research into gastric and duodenal ulcers.
- Orally active histamine H2-receptor antagonist
- Suppresses histamine release and inhibits proton secretion
- Inhibits production of VEGF-1
- Exhibits anti-allergic inflammatory effects
- Potential for research into gastric and duodenal ulcers
- Suppresses pro-inflammatory cytokine production and signaling pathways (in vitro)
- Inhibits inflammatory mediators such as PGE2, NO, and histamine (in vitro)
- Ameliorates allergic hypersensitivity and inflammation in anaphylactic animal models (in vivo)
eMolecules 72518-41-3 | 2-METHYL-2-PIPERIDINECARBOXYLIC ACID | AstaTech | MFCD01318631 | 143.186 | C7H13NO2 | 98.000 | CC1(CCCCN1)C(O)=O | 0.25g | 491175833
2-METHYL-2-PIPERIDINECARBOXYLIC ACID | AstaTech | 72518-41-3 | MFCD01318631 | 143.186 | C7H13NO2 | 98.000 | CC1(CCCCN1)C(O)=O | 0.25g | 491175833
eMolecules 5382-16-1 | 4-Hydroxypiperidine | Oakwood Chemical | MFCD00005999 | 101.149 | C5H11NO | 98.000 | OC1CCNCC1 | 500g | 599423880
4-Hydroxypiperidine | Oakwood Chemical | 5382-16-1 | MFCD00005999 | 101.149 | C5H11NO | 98.000 | OC1CCNCC1 | 500g | 599423880
Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 50 MG
GSK2879552 dihydrochloride is an orally active, selective, and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), which possesses potential antineoplastic activity. It is intended for research use only and not for patient use.
- Orally active, selective, and irreversible inhibitor
- Inhibits KDM1A histone demethylase activity
- Induces differentiation of sorafenib-resistant cells
- Attenuates stemness properties
- Depresses the transcription of Wnt antagonists
- Downregulates β-catenin signaling activity in sorafenib-resistant cells
- Inhibits cell proliferation in SCLC and AML cell lines
- Exhibits tumor growth inhibition in SCLC xenograft bearing mice
- Potential antineoplastic activity
- For research use only
Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | MFCD30481342 | 99.8% | 437.4 g·mol⁻1 | C23H30Cl2N2O2 | 10 MG
GSK2879552 dihydrochloride is the dihydrochloride salt of an orally bioavailable, selective, mechanism-based irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A). It is used as a research reagent in epigenetic and oncology studies and has been evaluated in early clinical trials for hematologic and solid tumor indications.
- Dihydrochloride salt form for improved solubility.
- Irreversible LSD1 inhibitor (mechanism-based inactivator).
- Orally bioavailable scaffold used in preclinical and clinical research.
- High purity (≈99.8%) suitable for research applications.
- Available in multiple solid and solution formats and milligram quantities.
Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 10 MG
pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 10 MG
Medchemexpress LLC pJAK2(1001-1013) | 1259928-08-9 | 99.9% | 1716.82 | 50 MG
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase, functioning as a SOCS1/3 antagonist. This peptide blocks SOCS1-mediated negative regulation of immune function and enhances the biological activity of cytokines such as IFNγ and IL6. It has been shown to inhibit the replication of a broad range of viruses and offers dose-dependent protective efficacy against lethal viral infections, making it suitable for studying immune regulation and infection.
- Functions as a SOCS1/3 antagonist
- Blocks SOCS1-mediated negative regulation of immune function
- Enhances biological activity of cytokines like IFNγ and IL6
- Inhibits replication of a broad range of viruses
- Offers dose-dependent protective efficacy against lethal viral infections
Medchemexpress LLC HY-114363A 5mg Medchemexpress, SRI 31215 (TFA) CAS:1832686-44-8 Purity:>98%
Medchemexpress, HY-114363A 5mg SRI 31215 (TFA) CAS:1832686-44-8 SRI 31215 (TFA), a triplex inhibitor of matriptase , hepsin and hepatocyte growth factor activator (HGFA) with IC 50 s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2 [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.