Pyrazines
TARGETMOL CHEMICALS INC AOH1996 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen) targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its binding proteins leading to DNA replication stress and apoptosis.AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II.AOH1996 acts synergistically with DNA damaging agents to inhibit tumor cell growth. AOH1996 inhibits tumor cell growth by stabilizing the interaction between PCNA and RNA polymerase II leading to proteasome-dependent rpb1 degradation and lethal DNA damage.AOH1996 acts synergistically with DNA damaging agents. purity: 98%
Apexbio Technology LLC 2,4-Diamino-6-hydroxypyrimidine 56-06-4 10mM (in 1mL DMSO)
2 4-Diamino-6-hydroxypyrimidine (CAS 56-06-4) is a small molecule inhibitor targeting GTP cyclohydrolase I the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin (BH4) By suppressing GTP cyclohydrolase I activity this compound reduces intracellular levels of BH4 consequently leading to decreased nitric oxide (NO) synthesis It is commonly utilized in studies investigating the roles of BH4 and NO in physiological and pathological contexts including research on neuronal signaling immune modulation and cardiovascular dysfunction
TARGETMOL CHEMICALS INC LEXIBULIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50 10-100 nM in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow and tumor cell death. purity: 99%
TARGETMOL CHEMICALS INC MICLXIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via (beta)-catenin.Miclxin is a potent inhibitor of mutant (beta)-catenin which is involved in the Wnt signaling pathway.Miclxin induces (beta)-catenin-dependent apoptosis leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60. purity: 99%
TARGETMOL CHEMICALS INC ENDOSIDIN-2 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Endosidin-2 is an exocyst inhibitor a cell-permeable benzylidene benzoylhydrazine that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 uM EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70 leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization. purity: 98%
Apexbio Technology LLC SCR7 pyrazine 14892-97-8 25mg
SCR7 pyrazine (CAS 14892-97-8) is a small-molecule inhibitor of DNA ligase IV a critical enzyme in the nonhomologous end-joining (NHEJ) pathway responsible for repairing DNA double-strand breaks (DSBs) By disrupting the DNA binding activity of ligase IV SCR7 impedes the NHEJ-mediated repair process leading to reduced cell viability and increased apoptosis In cellular assays SCR7 demonstrated dose-dependent inhibition of proliferation in various cancer cell lines with reported IC50 values ranging from 8 5 to 120 M Additionally in mouse models SCR7 administration suppressed tumor growth and enhanced sensitivity to DSB-inducing therapies highlighting its utility for studying DNA repair mechanisms and potential as an adjunct in cancer research
Apexbio Technology LLC SCR7 pyrazine 14892-97-8 10mg
SCR7 pyrazine (CAS 14892-97-8) is a small-molecule inhibitor of DNA ligase IV a critical enzyme in the nonhomologous end-joining (NHEJ) pathway responsible for repairing DNA double-strand breaks (DSBs) By disrupting the DNA binding activity of ligase IV SCR7 impedes the NHEJ-mediated repair process leading to reduced cell viability and increased apoptosis In cellular assays SCR7 demonstrated dose-dependent inhibition of proliferation in various cancer cell lines with reported IC50 values ranging from 8 5 to 120 M Additionally in mouse models SCR7 administration suppressed tumor growth and enhanced sensitivity to DSB-inducing therapies highlighting its utility for studying DNA repair mechanisms and potential as an adjunct in cancer research
TARGETMOL CHEMICALS INC VICENIN 2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 uM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of (alpha)-glucosidase PTP1B and RLAR. Vicenin 2 has hepatoprotective anti-cancer antioxidant and anti-inflammatory activities and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants. purity: 99%
Apexbio Technology LLC SCR7 pyrazine 14892-97-8 5mg
SCR7 pyrazine (CAS 14892-97-8) is a small-molecule inhibitor of DNA ligase IV a critical enzyme in the nonhomologous end-joining (NHEJ) pathway responsible for repairing DNA double-strand breaks (DSBs) By disrupting the DNA binding activity of ligase IV SCR7 impedes the NHEJ-mediated repair process leading to reduced cell viability and increased apoptosis In cellular assays SCR7 demonstrated dose-dependent inhibition of proliferation in various cancer cell lines with reported IC50 values ranging from 8 5 to 120 M Additionally in mouse models SCR7 administration suppressed tumor growth and enhanced sensitivity to DSB-inducing therapies highlighting its utility for studying DNA repair mechanisms and potential as an adjunct in cancer research
TARGETMOL CHEMICALS INC MMRI62 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MMRi62 (7-[(23-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53 also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. purity: 99%