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Filtered Search Results
Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000703752 EMIXUSTAT 25MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Takara Bio Trekker Starter Kit Bundle (UV Lamp)
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Trekker Starter Kit Bundle UV
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Medchemexpress LLC 24-Hydroxycholesterol | 30271-38-6 | 50 MG
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24-Hydroxycholesterol is a natural sterol. It functions as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptors and is a potent activator of the transcription factors LXR. This product is intended for research use only.
- Positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptors.
- Potent activator of the transcription factors LXR.
- Intended for research use only.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Fucoxanthin | 3351-86-8 | 1 ML
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Fucoxanthin is a marine carotenoid that exhibits various biological activities, including anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory, and anticancer properties. This product is supplied as a 10 mM solution in 1 mL of DMSO.
- High purity (99.38%)
- Molecular weight: 658.91
- Chemical formula: C42H58O6
- Targets multiple pathways, including PPARγ, UCP1, and caspases
- Shipped at room temperature
- Store at -80°C for up to 6 months or -20°C for up to 1 month when in solvent
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Medchemexpress LLC Deltonin | 55659-75-1 | 1 MG
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Deltonin is a steroidal saponin isolated from *Dioscorea zingiberensis* that exhibits antitumor activity by inhibiting ERK1/2 and AKT activation. In vitro studies demonstrate its ability to inhibit the proliferation of various colon cancer cell lines and induce apoptosis. In vivo, Deltonin has been shown to reduce tumor growth and inhibit tumor angiogenesis, contributing to increased survival rates in animal models.
- Steroidal saponin isolated from *Dioscorea zingiberensis*
- Exhibits antitumor activity
- Inhibits ERK1/2 and AKT activation
- Inhibits proliferation of colon cancer cell lines
- Causes G2-M phase arrest and induces apoptosis
- Decreases phosphorylation of AKT and ERK1/2 levels
- Inhibits proliferation and induces apoptosis with ROS production
- Reduces tumor growth in mice
- Inhibits tumor angiogenesis in mice
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Apexbio Technology LLC Naspm trihydrochloride 1049731-36-3 10mg
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Naspm trihydrochloride (CAS 1049731-36-3) is a selective inhibitor of Ca sup 2 /sup -permeable AMPA receptors a subtype of glutamate-gated ion channels involved in mediating fast excitatory synaptic transmission in the central nervous system This compound preferentially antagonizes AMPA receptors lacking the GluR2 subunit such as GluR1 homomeric channels exhibiting an IC sub 50 /sub of 0 3 M By blocking these receptors Naspm trihydrochloride is widely used to elucidate the physiological roles of Ca sup 2 /sup -permeable AMPA receptors in synaptic plasticity neuronal signaling and excitotoxicity research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000785034 ORMUTIVIMAB 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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5000294932 TENOVIN-3 10MG
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569627 EOAI3402143-5MG
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Apexbio Technology LLC ITSA-1 (ITSA1) 200626-61-5 100mg
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ITSA-1 (CAS 200626-61-5) is a small molecule identified as an activator of histone deacetylases (HDACs) specifically modulating the HDAC activity suppressed by trichostatin A (TSA) While TSA is a potent inhibitor of mammalian HDACs that induces accumulation of acetylated histones ITSA-1 counteracts TSA-induced histone acetylation In vitro studies demonstrate that ITSA-1 restores BrdU incorporation and normal cell cycle distribution in TSA-treated mouse embryonic stem cells and reduces acetylated histone H3 levels in TSA-exposed A549 cells ITSA-1 alone does not affect HDAC activity indicating an indirect modulatory mechanism ITSA-1 is primarily used as a probe to study intracellular histone acetylation and regulatory pathways of HDAC function
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Apexbio Technology LLC ML241 hydrochloride 2070015-13-1 10mg
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ML241 hydrochloride (CAS 2070015-13-1) is a selective inhibitor of the p97 ATPase a conserved hexameric member of the type II AAA ATPase protein family essential to eukaryotic cellular processes including cell division membrane fusion and autophagosome maturation ML241 exhibits an in vitro IC50 of 100 nM against p97 It impedes p97-dependent but not p97-independent proteasomal substrate degradation and disrupts endoplasmic reticulum-associated degradation pathways Compared to the related compound ML240 ML241 does not induce LC3-II accumulation or rapid activation of caspases in cancer cells ML241 has minimal off-target activity toward kinases and CNS-related proteins and is currently used in preclinical studies to elucidate p97 function and proteostasis mechanisms
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Ambeed AMBEED
5000868028 4-N-METHYLSULFAMOYLPHENYLB 1GR
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Apexbio Technology LLC ONO-7300243 638132-34-0 25mg
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ONO-7300243 (CAS 638132-34-0) is a small-molecule antagonist of lysophosphatidic acid receptor 1 (LPA1) exhibiting an in vitro IC50 of 160 nM LPA1 mediates responses to lysophosphatidic acid (LPA) a bioactive phospholipid involved in cellular proliferation calcium signaling cell survival and motility as well as physiological processes such as smooth muscle contraction and immune regulation In animal studies oral administration of ONO-7300243 significantly reduced urethral pressure without affecting systemic blood pressure indicating utility in benign prostatic hyperplasia (BPH) research Currently ONO-7300243 remains at the preclinical research stage
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Apexbio Technology LLC Tolvaptan 150683-30-0 10mM (in 1mL DMSO)
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Tolvaptan (CAS 150683-30-0) is a selective orally active antagonist of the arginine vasopressin (AVP) V2 receptor In binding assays using HeLa cells expressing human AVP receptor subtypes tolvaptan exhibits high affinity for the V2 receptor (Ki 0 43 nM) and substantially lower affinity for the V1a receptor (Ki 12 3 nM) with minimal activity at V1B and other off-target receptors or ion channels Tolvaptan inhibits AVP-induced cAMP accumulation with an IC50 of 8 nM In animal models administration of tolvaptan increases urine output and serum sodium and elevates plasma sodium while reducing mortality in hyponatremic rats This compound is widely utilized in research exploring water balance AVP signaling and hyponatremia mechanisms
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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5000586293 NICOTINIC ACID N-OXI 5G
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