Pyridines and derivatives
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- (1)
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DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor. This compound is intended for research use only and exhibits high purity.
- Potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
- Exhibits high purity.
- Stored at -20°C under nitrogen.
- When in solvent, store at -80°C for 6 months or -20°C for 1 month.
- Available as a white to yellow solid.
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Promega Corporation TRKA L657M KINASE ENZYME SYS
PRVA7567 TRKA L657M KINASE ENZYME SYS
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Medchemexpress LLC Colivelin | 867021-83-8 | 99.9% | 2645.10 | 5 MG
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Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. It suppresses neuronal death by activating STAT3 in vitro. Colivelin demonstrates long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. It has potential for treating Alzheimer's disease and ischemic brain injury.
- Suppresses neuronal death by activating STAT3 in vitro
- Demonstrates long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits
- Potential for treating Alzheimer's disease and ischemic brain injury
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TARGETMOL CHEMICALS INC DMU-212 25MG
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Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 uM) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5)[1]. At concentrations of 30-50 uM over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. 2015 Aug;24(8)632-4. Purity 99.64%
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Medchemexpress LLC IDO-1 Mouse His 500ug
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IDO Protein an enzyme is involved in the metabolism of tryptophan Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism enhancing immune responses and inhibiting tumor growth IDO-1 Protein Mouse (His) is the recombinant mouse-derived IDO protein expressed by E coli with N-6 His labeled tag
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Apexbio Technology LLC ML-265 1221186-53-3 25mg
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ML-265 (CAS 1221186-53-3) is a potent and selective small-molecule activator of pyruvate kinase M2 (PKM2) PKM2 regulates the final step of glycolysis and is predominantly expressed in highly proliferative cells including cancer cells ML-265 activates PKM2 with an AC50 of 92 nM demonstrating high selectivity over other pyruvate kinase isoforms It enhances PKM2 activity by promoting tetramer formation and lowers the enzyme s Km for phosphoenolpyruvate similar to the effect of fructose-1 6-bisphosphate In mouse xenograft models ML-265 shows favorable pharmacokinetics and suppresses tumor growth supporting its utility in studies of cancer metabolism and tumorigenesis
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![Medchemexpress LLC Imidazo[5,1-f]triazin-4(1H)-one, 2-[2-ethoxy-5-(4-morpholinylsulfonyl)phenyl]-5-methyl | 224788-36-7 | MFCD01346226 | 99.6% | 461.53 g/mol | C21H27N5O5S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221264.png-250.jpg)
Medchemexpress LLC Imidazo[5,1-f]triazin-4(1H)-one, 2-[2-ethoxy-5-(4-morpholinylsulfonyl)phenyl]-5-methyl | 224788-36-7 | MFCD01346226 | 99.6% | 461.53 g/mol | C21H27N5O5S | 5 MG
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PDE5-IN-4 is a small-molecule phosphodiesterase 5 (PDE5) inhibitor supplied for research use. The compound is provided as a solid with high reported purity and is used in preclinical studies investigating acute myocardial infarction and reperfusion injury, gastrointestinal disorders, diabetes-related tissue damage, and liver failure.
- High purity of 99.6%.
- Molecular formula C21H27N5O5S.
- Molecular weight 461.53 g/mol.
- Available in small pack sizes, including 5 mg.
- Powder storage: -20°C for up to 3 years or 4°C for up to 2 years.
- In solvent storage: -80°C for up to 6 months or -20°C for up to 1 month.
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Medchemexpress LLC Vedaprofen (standard) | 71109-09-6 | MFCD00866019 | 282.38 g/mol | C19H22O2 | 5 MG
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Vedaprofen is a COX-1 selective nonsteroidal anti-inflammatory drug supplied as a research standard for analytical and preclinical studies. The compound has molecular formula C19H22O2 and molecular weight 282.38 g/mol, and is offered in small, accurately measured pack sizes for assay and reference use.
- COX-1 selective nonsteroidal anti-inflammatory agent.
- Suitable as a reference standard for analytical and pharmacological studies.
- Molecular formula C19H22O2; molecular weight 282.38 g/mol.
- Available in small pack sizes for precise dosing and assay preparation.
- Includes datasheet and safety data sheet documentation for handling and storage.
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