Pyridines and derivatives
1-Butylpyridinium Hexafluorophosphate 98.0+%, TCI America™
CAS: 186088-50-6 Molecular Formula: C9H14F6NP Molecular Weight (g/mol): 281.18 MDL Number: MFCD03093297 InChI Key: CTMFVASPBJWPFC-UHFFFAOYSA-N Synonym: 1-butylpyridinium hexafluorophosphate,n-butylpyridinium hexafluorophosphate,1-butylpyridin-1-ium hexafluorophosphate v,1-butylpyridin-1-ium hexafluorophosphate,acmc-1c03e,dsstox_cid_27908,dsstox_rid_82661,dsstox_gsid_47932,ksc171g1j PubChem CID: 2734176 IUPAC Name: 1-butylpyridin-1-ium; hexafluoro-λ⁵-phosphanuide SMILES: F[P-](F)(F)(F)(F)F.CCCC[N+]1=CC=CC=C1
1-Ethyl-3-methylpyridinium Ethyl Sulfate 98.0+%, TCI America™
CAS: 872672-50-9 Molecular Formula: C10H17NO4S Molecular Weight (g/mol): 247.309 InChI Key: ZTLWMUBOQHZKNS-UHFFFAOYSA-M PubChem CID: 44629805 IUPAC Name: 1-ethyl-3-methylpyridin-1-ium;ethyl sulfate SMILES: CC[N+]1=CC=CC(=C1)C.CCOS(=O)(=O)[O-]
3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 98.0+%, TCI America™
CAS: 893440-50-1 Molecular Formula: C12H19BN2O3 Molecular Weight (g/mol): 250.11 MDL Number: MFCD12923427 InChI Key: KYYKGOURQXPERA-UHFFFAOYSA-N Synonym: 2-methoxy-5-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl pyridin-3-amine,3-amino-2-methoxypyridine-5-boronic acid pinacol ester,5-amino-6-methoxypyridine-3-boronic acid pinacol ester,2-methoxy-5-4,4,5,5-tetramethyl-1,3,2 dioxaborolan-2-yl-pyridin-3-ylamine,2-methoxy-3-aminopyridine-5-boronic acid pinacol ester,5-amino-6-methoxypyridin-3-yl boronic acid pinacol ester,2-methoxy-5-tetramethyl-1,3,2-dioxaborolan-2-yl pyridin-3-amine,5-amino-6-methoxypyridine-3-boronic acid pinacol ester?,3-amino-2-methoxypyridin-5-ylboronicacidpinacolester,5-amino-6-methoxypyridine-3-boronicacidpinacolester PubChem CID: 59557920 IUPAC Name: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine SMILES: COC1=C(N)C=C(C=N1)B1OC(C)(C)C(C)(C)O1
Apexbio Technology LLC PND-1186 1061353-68-1 5mg
PND-1186 (CAS 1061353-68-1) is a reversible ATP-competitive small molecule inhibitor of focal adhesion kinase (FAK) a cytoplasmic protein tyrosine kinase implicated in integrin- and growth-factor receptor-mediated signaling PND-1186 inhibits FAK enzymatic activity with an IC50 of 1 5 nM and suppresses autophosphorylation at Tyr-397 at approximately 0 1 1 M in various tumor cell lines thereby disrupting downstream signaling pathways involved in cell migration proliferation and survival In preclinical studies using breast and ovarian cancer models PND-1186 treatment reduces FAK phosphorylation inhibits tumor growth induces apoptosis and decreases metastatic activity highlighting its potential utility in cancer biology research
Apexbio Technology LLC PND-1186 1061353-68-1 10mg
PND-1186 (CAS 1061353-68-1) is a reversible ATP-competitive small molecule inhibitor of focal adhesion kinase (FAK) a cytoplasmic protein tyrosine kinase implicated in integrin- and growth-factor receptor-mediated signaling PND-1186 inhibits FAK enzymatic activity with an IC50 of 1 5 nM and suppresses autophosphorylation at Tyr-397 at approximately 0 1 1 M in various tumor cell lines thereby disrupting downstream signaling pathways involved in cell migration proliferation and survival In preclinical studies using breast and ovarian cancer models PND-1186 treatment reduces FAK phosphorylation inhibits tumor growth induces apoptosis and decreases metastatic activity highlighting its potential utility in cancer biology research
Apexbio Technology LLC PND-1186 1061353-68-1 50mg
PND-1186 (CAS 1061353-68-1) is a reversible ATP-competitive small molecule inhibitor of focal adhesion kinase (FAK) a cytoplasmic protein tyrosine kinase implicated in integrin- and growth-factor receptor-mediated signaling PND-1186 inhibits FAK enzymatic activity with an IC50 of 1 5 nM and suppresses autophosphorylation at Tyr-397 at approximately 0 1 1 M in various tumor cell lines thereby disrupting downstream signaling pathways involved in cell migration proliferation and survival In preclinical studies using breast and ovarian cancer models PND-1186 treatment reduces FAK phosphorylation inhibits tumor growth induces apoptosis and decreases metastatic activity highlighting its potential utility in cancer biology research
Apexbio Technology LLC PND-1186 1061353-68-1 100mg
PND-1186 (CAS 1061353-68-1) is a reversible ATP-competitive small molecule inhibitor of focal adhesion kinase (FAK) a cytoplasmic protein tyrosine kinase implicated in integrin- and growth-factor receptor-mediated signaling PND-1186 inhibits FAK enzymatic activity with an IC50 of 1 5 nM and suppresses autophosphorylation at Tyr-397 at approximately 0 1 1 M in various tumor cell lines thereby disrupting downstream signaling pathways involved in cell migration proliferation and survival In preclinical studies using breast and ovarian cancer models PND-1186 treatment reduces FAK phosphorylation inhibits tumor growth induces apoptosis and decreases metastatic activity highlighting its potential utility in cancer biology research
Medchemexpress LLC MSC-1186 | 2871698-23-4 | 98.95% | 461.90 | 50 MG
MSC-1186 | 2871698-23-4 | 98.95% | 461.90 | 50 MG
Medchemexpress LLC MSC-1186 | 2871698-23-4 | 98.95% | 461.90 | 1 ML
MSC-1186 is a chemical probe and a highly selective pan-SRPK inhibitor. It demonstrates activity for SRPK1, SRPK2, and SRPK3 with IC50 values of 2.7 nM, 81 nM, and 0.6 nM, respectively. This compound can be utilized in cancer research.
- Highly selective pan-SRPK inhibitor
- Active against SRPK1, SRPK2, and SRPK3
- Can be used for cancer research
- Exhibits excellent kinome-wide selectivity
- Shows additive attenuation of SR-protein phosphorylation when used with CLK inhibitors
Apexbio Technology LLC Estriol 50-27-1 500mg
Estriol (50-27-1) is a small-molecule estrogen receptor modulator targeting the G-protein coupled estrogen receptor (GPER) It is designed to antagonize GPER-dependent estrogen signaling thereby regulating estrogen-mediated cellular pathways independent of classical nuclear receptors Estriol exerts its biological activity primarily through antagonistic interaction with GPER In cell-based studies estriol demonstrates receptor-selective antagonistic activity in estrogen receptor-negative breast cancer cell lines Based on these pharmacological properties estriol holds research potential in oncology investigations involving hormone receptor-negative breast cancer and in the study of estrogen receptor-independent signaling pathways
Medchemexpress LLC Tetrahydrouridine | 18771-50-1 | C9H16N2O6 | 50 MG
Tetrahydrouridine dihydrate is a potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine. It is for research use only. Tetrahydrouridine (THU) is a specific inhibitor of cytidine deaminase (CDA) that can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues.
- Competitively blocks the enzyme's active site more effectively than intrinsic cytidine
- Can sensitize some pancreatic and lung carcinoma cells to gemcitabine-induced cell death
- Inhibits S-phase without inducing apoptosis
Medchemexpress LLC Estriol | 50-27-1 | MFCD00003691 | >99.6% | 50 MG
Estriol (Standard) is the analytical standard of Estriol. This product is intended for research and analytical applications. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Intended for research and analytical applications
- Used in qualitative, quantitative and methodological research experiments
- Suitable for HPLC, GC and MS
Medchemexpress LLC BMS-209641 | 369364-50-1 | 98.1% | 50 MG
BMS641 (BMS-209641) is a selective retinoic acid receptor β (RARβ) agonist used in biochemical and pharmacological research. It shows strong selectivity for RARβ over RARα and RARγ, and is provided as a white to off-white solid for use in in vitro and in vivo studies. Not for human use.
- Selective RARβ agonist with high affinity (Kd ≈ 2.5 nM)
- Approximately 100-fold selectivity versus RARα and RARγ
- High purity suitable for research applications
- Molecular weight 414.92 g/mol and formula C27H23ClO2
- Soluble in DMSO and formulatable for in vivo dosing
- Stable as a powder under recommended storage conditions
Medchemexpress LLC Direct red 254 | 6300-50-1 | 50 MG
Direct red 254 is a good dyeing agent for cotton fabrics.
- Fluorescent dye
- Used in labeling chemistry
- Suitable for chemical stain analysis
- Chemical analytical dye
Medchemexpress LLC Dynamin IN-1 | 1345853-50-0 | C23H24N2O | 50 MG
Dynamin IN-1 is a potent dynamin inhibitor with an IC50 value of 1.0 μM. This compound is intended for research use only and is not sold for patient use.
- Potent dynamin inhibitor
- IC50 value of 1.0 μM
- For research use only
- Purity of 99.89%
- Molecular weight: 344.45
- Appearance: Solid, white to off-white