Pyridines and derivatives
4-Bromo-2-methylpyridine, 97%
CAS: 22282-99-1 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.03 MDL Number: MFCD03788196 InChI Key: JFBMFWHEXBLFCR-UHFFFAOYSA-N Synonym: 4-bromo-2-picoline,2-methyl-4-bromopyridine,4-bromo-2-methyl-pyridine,pyridine, 4-bromo-2-methyl,4-bromopicoline,zlchem 422,pubchem4035,acmc-209fui,4-bromo-methyl-pyridine PubChem CID: 2762835 IUPAC Name: 4-bromo-2-methylpyridine SMILES: CC1=CC(Br)=CC=N1
2-Bromo-6-(trifluoromethyl)pyridine, 97%
CAS: 189278-27-1 Molecular Formula: C6H3BrF3N Molecular Weight (g/mol): 226.00 MDL Number: MFCD00153087 InChI Key: DOWNSQADAFSSAR-UHFFFAOYSA-N Synonym: 2-bromo-6-trifluoromethyl pyridine,pyridine, 2-bromo-6-trifluoromethyl,2-trifluoromethyl-6-bromopyridine,2-bromo-6-trifluoromethyl-pyridine,6-bromo-2-trifluoromethyl pyridine,2-bromo-6-trifluromethylpyridine,2-bromo-6-trifluormethyl-pyridine,pubchem9307,acmc-209esf,ksc495o4t PubChem CID: 2782902 IUPAC Name: 2-bromo-6-(trifluoromethyl)pyridine SMILES: FC(F)(F)C1=NC(Br)=CC=C1
2-Bromo-4-(trifluoromethyl)pyridine, 97%
CAS: 175205-81-9 Molecular Formula: C6H3BrF3N Molecular Weight (g/mol): 225.996 MDL Number: MFCD00153085 InChI Key: WZVHLUMAQLUNTJ-UHFFFAOYSA-N Synonym: 2-bromo-4-trifluoromethyl pyridine,pyridine, 2-bromo-4-trifluoromethyl,2-bromo-4-trifluoromethyl-pyridine,2-bromo-4-trifluormethyl pyridine,pubchem8064,acmc-209e9d,abbypharma ap-11-5529 PubChem CID: 2781543 IUPAC Name: 2-bromo-4-(trifluoromethyl)pyridine SMILES: C1=CN=C(C=C1C(F)(F)F)Br
Nalidixic acid, 99%
CAS: 389-08-2 Molecular Formula: C12H12N2O3 Molecular Weight (g/mol): 232.239 MDL Number: MFCD00006884 InChI Key: MHWLWQUZZRMNGJ-UHFFFAOYSA-N Synonym: nalidixic acid,nalidixin,nevigramon,nalidixate,uronidix,innoxalon,nalidixan,nalitucsan,sicmylon,unaserus PubChem CID: 4421 ChEBI: CHEBI:100147 IUPAC Name: 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)O
2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine 98.0+%, TCI America™
CAS: 49669-14-9 Molecular Formula: C9H10BrNO2 Molecular Weight (g/mol): 244.088 MDL Number: MFCD12406888 InChI Key: ZRXWMMNBTGBCIL-UHFFFAOYSA-N Synonym: 2-bromo-6-2-methyl-1,3-dioxolan-2-yl pyridine,2-bromo-6-2-methyl-1,3-dioxolan-2-yl-pyridine,pyridine, 2-bromo-6-2-methyl-1,3-dioxolan-2-yl,pubchem16082,ksc496i5p,2-bromo-6-2-methyl-1,3-dioxolane-2-yl pyridine,2-bromanyl-6-2-methyl-1,3-dioxolan-2-yl pyridine,2-bromo-6-2-methyl-1,3 dioxolan-2-yl-pyridine,6-bromo-2-2'-methyl-1',3'-dioxolan-2'-yl-pyridine PubChem CID: 12164282 IUPAC Name: 2-bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine SMILES: CC1(OCCO1)C2=NC(=CC=C2)Br
2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 98.0+%, TCI America™
CAS: 452972-14-4 Molecular Formula: C11H15BFNO2 Molecular Weight (g/mol): 223.054 MDL Number: MFCD00016604 InChI Key: YYOZFGQOPNTVGM-UHFFFAOYSA-N Synonym: 2-fluoropyridine-3-boronic acid pinacol ester,2-fluoro-3-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl pyridine,2-fluoropyridine-3-boronic acid, pinacol ester,pyridine, 2-fluoro-3-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl,2-fluoro-3-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl pyridine,2-fluoropyridin-3-yl boronic acid pinacol ester,2-fluoro-3-tetramethyl-1,3,2-dioxaborolan-2-yl pyridine,2-fluoropyridine-3-boronic pound inverted question markacid pound inverted question markpinacol pound inverted question markester,pubchem24045,2-fluoropyridine-3-boronicacidpinacolester PubChem CID: 12067063 IUPAC Name: 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine SMILES: B1(OC(C(O1)(C)C)(C)C)C2=C(N=CC=C2)F
Medchemexpress LLC Dendrophenol | 108853-14-1 | 1 MG
Dendrophenol (Moscatilin) is an NF-κB inhibitor that inhibits inflammation. It exerts a potent cytotoxic effect against tumor cells, inducing cell cycle arrest and apoptosis, and demonstrates antitumor activity. Additionally, Dendrophenol can inhibit vascular calcification by suppressing the activation of WNT3/β-catenin.
- Inhibits expression of COX-2, iNOS, HIF-1α, and NF-κB in LPS-treated macrophages.
- Exerts cytotoxic effects against tumor cell lines and causes cell G2 phase arrest.
- Reduces calcium deposition via the WNT3/β-catenin pathway.
- Induces apoptosis in human colon cancer cell HCT-116.
- Shows beneficial effects in a mouse model of vascular calcification.
- Exhibits antitumor effects in a mouse tumor model.
Apexbio Technology LLC AZ3146 1124329-14-1 50mg
AZ3146 (CAS 1124329-14-1) is a potent and selective inhibitor of monopolar spindle 1 (Mps1) kinase exhibiting an IC50 of 35 nM Mps1 kinase is crucial for various stages of mitosis including chromosome attachment and centrosome function and is involved in multiple post-mitotic signaling pathways In cell-based studies AZ3146 disrupts chromosome alignment and alters spindle assembly checkpoint activity by interfering with the recruitment of spindle checkpoint proteins such as Mad1 and Mad2 to kinetochores This compound is widely utilized to investigate mitotic regulation and checkpoint signaling in cellular and animal models
Apexbio Technology LLC Guaifenesin 93-14-1 5g
Guaifenesin (93-14-1) is a small-molecule expectorant designed to modulate respiratory epithelial cell secretion thereby regulating mucus viscosity and bronchial mucus clearance in the respiratory tract Guaifenesin exerts its biological activity primarily through enhancement of respiratory tract hydration and reduction of mucus viscosity via direct modulation of respiratory epithelial cells Based on these pharmacological properties guaifenesin holds research potential in studies of mucus clearance mechanisms bronchial secretion regulation and potential application in neuromuscular activity modulation with exploratory investigations in fibromyalgia symptom management and reproductive biology
Medchemexpress LLC PD-1 Cynomolgus 14 5ug
Recombinant cynomolgus PD-1 extracellular domain (P21-Q167), expressed in HEK293 cells and supplied as a His-tagged, lyophilized protein. The product is formulated from PBS (pH 7.4), has low endotoxin, and is functionally validated by ELISA for binding to PD-L1 (ED50 260.2 ng/mL). Recommended storage is -20°C; reconstituted material is stable short term at 4°C.
Apexbio Technology LLC AZ3146 1124329-14-1 100mg
AZ3146 (CAS 1124329-14-1) is a potent and selective inhibitor of monopolar spindle 1 (Mps1) kinase exhibiting an IC50 of 35 nM Mps1 kinase is crucial for various stages of mitosis including chromosome attachment and centrosome function and is involved in multiple post-mitotic signaling pathways In cell-based studies AZ3146 disrupts chromosome alignment and alters spindle assembly checkpoint activity by interfering with the recruitment of spindle checkpoint proteins such as Mad1 and Mad2 to kinetochores This compound is widely utilized to investigate mitotic regulation and checkpoint signaling in cellular and animal models
Apexbio Technology LLC AZ3146 1124329-14-1 10mg
AZ3146 (CAS 1124329-14-1) is a potent and selective inhibitor of monopolar spindle 1 (Mps1) kinase exhibiting an IC50 of 35 nM Mps1 kinase is crucial for various stages of mitosis including chromosome attachment and centrosome function and is involved in multiple post-mitotic signaling pathways In cell-based studies AZ3146 disrupts chromosome alignment and alters spindle assembly checkpoint activity by interfering with the recruitment of spindle checkpoint proteins such as Mad1 and Mad2 to kinetochores This compound is widely utilized to investigate mitotic regulation and checkpoint signaling in cellular and animal models
Medchemexpress LLC Dendrophenol | 108853-14-1 | 5 MG
Dendrophenol, also known as Moscatilin, is a potent NF-κB inhibitor that exhibits anti-inflammatory properties. It demonstrates significant cytotoxic effects against various tumor cells, leading to cell cycle arrest and apoptosis. This compound also possesses antitumor activity and can inhibit vascular calcification by targeting the WNT3/β-catenin pathway.
- Inhibits inflammation through NF-κB pathway
- Exerts cytotoxic effects against tumor cells
- Induces cell cycle arrest and apoptosis in tumor cells
- Shows antitumor activity
- Inhibits vascular calcification by modulating WNT3/β-catenin activation
- Reduces expression of COX-2, iNOS, and HIF-1α
- Induces apoptosis in human colon cancer cells
Medchemexpress LLC Guaifenesin | 93-14-1 | 99.9% | 1 G
Guaifenesin, also known as Guaiacol glyceryl ether, is an expectorant derived from the guaiac resin of Guajacum officinale Linné. It is used to alleviate cough discomfort by increasing sputum volume and decreasing its viscosity, thereby promoting effective cough.
- Alleviates cough discomfort
- Increases sputum volume
- Decreases sputum viscosity
- Promotes effective cough
- Inhibits mucin release in epithelial cultures (in vitro)
- Inhibits IL-13-induced MUC5AC content and secretion in primary human airway epithelial cells (in vitro)
Medchemexpress LLC Neoandrographolide | 27215-14-1 | 480.59 | 1 ML
Neoandrographolide is a diterpenoid compound derived from Andrographis paniculata. It inhibits osteoclast differentiation and bone resorption by targeting the MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Additionally, it prevents apoptosis in rat embryonic ventricular cardiomyocytes, and demonstrates anti-inflammatory and hypolipidemic effects by suppressing inducible nitric oxide synthase (iNOS) and reactive oxygen species (ROS) generation, while simultaneously activating endothelial nitric oxide synthase (eNOS).
- Inhibits osteoclast differentiation.
- Alleviates bone resorption.
- Inhibits apoptosis in rat embryonic ventricular cardiomyocytes.
- Exhibits anti-inflammatory activity.
- Shows hypolipidemic activity.