Pyridines and derivatives
2-Bromo-5-nitropyridine 98.0+%, TCI America™
CAS: 4487-59-6 Molecular Formula: C5H3BrN2O2 Molecular Weight (g/mol): 203.00 MDL Number: MFCD00006222 InChI Key: HUUFTVUBFFESEN-UHFFFAOYSA-N Synonym: 2-bromo-5-nitro pyridine,2-bromo-5-nitro-pyridine,5-nitro-2-bromopyridine,2-brom-5-nitropyridin,pubchem1183,acmc-1agnm,2-bromo-5-nitro-pyridin,ksc237s9f,tpc-py095 PubChem CID: 78240 IUPAC Name: 2-bromo-5-nitropyridine SMILES: [O-][N+](=O)C1=CC=C(Br)N=C1
Nicotinic Acid 99.0+%, TCI America™
CAS: 59-67-6 Molecular Formula: C6H5NO2 Molecular Weight (g/mol): 123.11 MDL Number: MFCD00006391 InChI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N Synonym: nicotinic acid,niacin,3-pyridinecarboxylic acid,3-carboxypyridine,wampocap,acidum nicotinicum,apelagrin,pellagrin,akotin,daskil PubChem CID: 938 ChEBI: CHEBI:15940 IUPAC Name: pyridine-3-carboxylic acid SMILES: OC(=O)C1=CC=CN=C1
1-Butyl-4-methylpyridinium Bromide 98.0+%, TCI America™
CAS: 65350-59-6 Molecular Formula: C10H16BrN Molecular Weight (g/mol): 230.149 InChI Key: UWVZAZVPOZTKNM-UHFFFAOYSA-M PubChem CID: 13487610 IUPAC Name: 1-butyl-4-methylpyridin-1-ium;bromide SMILES: CCCC[N+]1=CC=C(C=C1)C.[Br-]
Nicotinic Acid 99.5+%, TCI America™
CAS: 59-67-6 Molecular Formula: C6H5NO2 Molecular Weight (g/mol): 123.11 MDL Number: MFCD00006391 InChI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N Synonym: nicotinic acid,niacin,3-pyridinecarboxylic acid,3-carboxypyridine,wampocap,acidum nicotinicum,apelagrin,pellagrin,akotin,daskil PubChem CID: 938 ChEBI: CHEBI:15940 IUPAC Name: pyridine-3-carboxylic acid SMILES: OC(=O)C1=CC=CN=C1
Apexbio Technology LLC AM095 1345614-59-6 50mg
AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
Apexbio Technology LLC AM095 1345614-59-6 10mg
AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
Apexbio Technology LLC Fluazinam 79622-59-6 500mg
Fluazinam (CAS 79622-59-6) is a small-molecule inhibitor targeting fungal mitochondrial respiratory chain complex II (succinate dehydrogenase SDH) It is designed to disrupt electron transfer during cellular respiration thereby impairing ATP production crucial for fungal cell viability Fluazinam exerts its biological activity primarily through inhibition of mitochondrial SDH In biochemical assays Fluazinam demonstrates inhibitory activity with reported IC50 values ranging from approximately 0 03 to 0 12 M against fungal SDH Based on these pharmacological properties Fluazinam holds research potential in investigating antifungal resistance mechanisms mitochondrial respiration impairment energy metabolism alterations and oxidative stress-related signal transduction pathways
Medchemexpress LLC Xylotriose | 47592-59-6 | 1 MG
Xylotriose is a natural xylooligosaccharide that functions as a bifidogenic factor. It acts as an inducer of the xylanase Xyn5 on the cell surface of *Paenibacillus sp. W-61*, enhancing the activity of the xyn5 promoter and promoting xylan utilization by bacteria. This product is for research use only.
- Natural xylooligosaccharide
- Acts as a bifidogenic factor
- Induces xylanase Xyn5 activity
- Enhances xyn5 promoter activity
- Promotes xylan utilization by bacteria
Apexbio Technology LLC Ginsenoside Re 52286-59-6 20mg
Ginsenoside Re (CAS 52286-59-6) is a natural saponin isolated from Panax notoginseng In neurobiological research it has been shown to reduce -amyloid (A ) levels and inhibit the c-Jun N-terminal kinase (JNK) signaling pathway as well as the activity of the NF- B transcription factor These properties implicate Ginsenoside Re in the modulation of neuroinflammatory and neurodegenerative processes The compound is commonly utilized in experimental models to investigate the molecular mechanisms underlying Alzheimer s disease neurodegeneration and inflammatory signaling pathways
Apexbio Technology LLC Tiagabine hydrochloride 145821-59-6 10mg
Tiagabine hydrochloride (CAS 145821-59-6) is a selective inhibitor of the GAT-1 subtype -aminobutyric acid (GABA) transporter By blocking GAT-1-mediated reuptake tiagabine hydrochloride elevates extracellular GABA concentrations and potentiates GABAergic inhibitory neurotransmission Experimental studies demonstrate its capacity to suppress GABA uptake in neuronal glial and synaptic models at varying levels This compound is widely utilized in research on epileptic seizure mechanisms and for investigating neuroprotective effects in models of neurodegenerative disorders associated with disrupted GABA metabolism
Medchemexpress LLC Ginsenoside Re | 52286-59-6 | 10 MG
Ginsenoside Re is a natural triterpenoid saponin isolated from Panax species, provided as a powder for research applications. It is commonly used in studies of inflammation, amyloid-β modulation, and cardiovascular effects. The compound has CAS number 52286-59-6 and a molecular weight of 947.15 g/mol. Recommended storage conditions include -20°C for long-term storage and 4°C for short-term storage.
Medchemexpress LLC Epoxyazadiradione | 18385-59-6 | 466.57 | 5 MG
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. It inhibits the tautomerase activity of MIF (macrophage migration inhibitory factor) from both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). It has potential against proinflammatory reactions induced by MIF of both malaria parasites and human.
- Purified from neem (Azadirachta indica) fruits
- Inhibits tautomerase activity of MIF from human and malaria parasites
- Non-competitive and reversible inhibition (Ki, 2.11-5.23 μM)
- Potential against proinflammatory reactions induced by MIF
Medchemexpress LLC Fluazinam | 79622-59-6 | 99.4% | 1 ML
Fluazinam is an orally active dinitroaniline fungicide. It induces phosphorylation of JNK, activates the p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, and increases Autophagy and Apoptosis. Fluazinam exhibits strong antifungal activity against F. fujikuroi and B. maydis. It also has a negative impact on Brachydanio rerio and worker bees.
- Induces phosphorylation of JNK
- Activates p38 pathway
- Decreases Bcl-2
- Activates caspase-3
- Decreases complex I activity
- Increases autophagy and apoptosis
- Exhibits strong antifungal activity
Medchemexpress LLC Rotigotine | 99755-59-6 | C19H25NOS | 5 MG
Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. It is also a partial agonist of the 5-HT1A receptor and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for Parkinson's disease (PD) research.
- Potent dopamine receptor agonist
- Partial agonist of the 5-HT1A receptor
- Antagonist of the α2B-adrenergic receptor
- Useful for Parkinson's disease (PD) research
Medchemexpress LLC Fluazinam | 79622-59-6 | 99.4% | 5 G
Fluazinam is an orally active dinitroaniline fungicide. It induces phosphorylation of JNK, activates the p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, and increases Autophagy and Apoptosis. Fluazinam exhibits strong antifungal activity against *F. fujikuroi* and *B. maydis*. It also has a negative impact on *Brachydanio rerio* and worker bees.
- Induces SH-SY5Y cell death and nuclear damage.
- Demonstrates great control efficiency against *B. maydis* on detached corn leaves.
- Shows strong antifungal activity against *F. fujikuroi*.
- Impairs oxidative phosphorylation and induces hyper/hypo-activity in zebrafish larvae.
- Exhibits acute toxicity to *Brachydanio rerio*.
- Reduces food consumption, damages midgut epithelium, increases autophagy and apoptosis in the midgut, induces oxidative stress, and alters walking behavior in worker bees.