Pyridines and derivatives
2-Bromo-6-fluoropyridine 98.0+%, TCI America™
CAS: 144100-07-2 Molecular Formula: C5H3BrFN Molecular Weight (g/mol): 175.988 MDL Number: MFCD03095258 InChI Key: ZIDIKYIZXMYHAW-UHFFFAOYSA-N Synonym: 6-bromo-2-fluoropyridine,2-fluoro-6-bromopyridine,2-bromo-6-fluoro-pyridine,pyridine, 2-bromo-6-fluoro,abbypharma ap-17-5098,acmc-1cab6,2-bromo-6-fluoro pyridine,ksc485m5f,platinum 1+ , 2-bromo-5-fluoropyridine-n 9-hydroxy-6-methylpyrido 2,3-a pyrrolo 3,4-c carbazole-5,7 1h,6h-dionato-n1,n12 6-methyl-3-pyridinol-n1-, sp-4-2-, hexafluorophosphate 1- PubChem CID: 639438 IUPAC Name: 2-bromo-6-fluoropyridine SMILES: C1=CC(=NC(=C1)Br)F
2-Methyl-8-nitroquinoline 98.0+%, TCI America™
CAS: 881-07-2 Molecular Formula: C10H8N2O2 Molecular Weight (g/mol): 188.19 MDL Number: MFCD00006764 InChI Key: UHPGVDHXHDPYQP-UHFFFAOYSA-N PubChem CID: 13433 IUPAC Name: 2-methyl-8-nitroquinoline SMILES: CC1=CC=C2C=CC=C(C2=N1)[N+]([O-])=O
3-Methylpyridine-2-carboxylic Acid 98.0+%, TCI America™
CAS: 4021-07-2 Molecular Formula: C7H7NO2 Molecular Weight (g/mol): 137.14 MDL Number: MFCD00191553 InChI Key: LMHIBYREWJHKNZ-UHFFFAOYSA-N Synonym: 3-methylpicolinic acid,3-methyl-2-pyridinecarboxylic acid,3-methyl-2-picolinic acid,2-pyridinecarboxylic acid, 3-methyl,3-methyl-a-picolinic acid,3-methyl-alpha-picolinic acid,3-methylpyridine-2-carboxylicacid,methylpyridincarbonsaure,pubchem14396,pubchem17659 PubChem CID: 268757 IUPAC Name: 3-methylpyridine-2-carboxylic acid SMILES: CC1=C(N=CC=C1)C(=O)O
Methyl Pyridine-2-carboxylate 98.0+%, TCI America™
CAS: 7-6-2459 Molecular Formula: C7H7NO2 Molecular Weight (g/mol): 137.14 MDL Number: MFCD00038038 InChI Key: NMMIHXMBOZYNET-UHFFFAOYSA-N Synonym: methyl picolinate,2-picolinic acid methyl ester,2-pyridinecarboxylic acid, methyl ester,methyl 2-pyridinecarboxylate,picolinic acid, methyl ester,2-carbomethoxypyridine,pyridine-2-carboxylic acid methyl ester,2-pyridinecarboxylic acid methyl ester,picolinic acid methyl ester,methylpicolinate PubChem CID: 75569 IUPAC Name: methyl pyridine-2-carboxylate SMILES: COC(=O)C1=CC=CC=N1
Dimethyl 2,2'-Bipyridine-6,6'-dicarboxylate 95.0+%, TCI America™
CAS: 142593-07-5 Molecular Formula: C14H12N2O4 Molecular Weight (g/mol): 272.26 MDL Number: MFCD11042478 InChI Key: YFKCGCGCKIYMIH-UHFFFAOYSA-N Synonym: 2,2′C-Bipyridine-6,6′C-dicarboxylic Acid Dimethyl Ester, 6,6′C-Bis(methoxycarbonyl)-2,2′C-bipyridine, 6,6′C-Dimethoxycarbonyl-2,2′C-bipyridine PubChem CID: 11477388 IUPAC Name: methyl 6-(6-methoxycarbonylpyridin-2-yl)pyridine-2-carboxylate SMILES: COC(=O)C1=CC=CC(=N1)C2=NC(=CC=C2)C(=O)OC
Apexbio Technology LLC Naftopidil 57149-07-2 5g
Naftopidil (CAS 57149-07-2) is a small molecule that functions as a selective antagonist of 1-adrenergic receptors By blocking these receptors naftopidil inhibits adrenergic signaling associated with smooth muscle contraction in the lower urinary tract and vascular tissues In clinical studies administration of naftopidil has been associated with significant improvements in international prostatic symptom scores demonstrating its impact on lower urinary tract symptoms Naftopidil is primarily investigated for its antihypertensive properties and its potential to ameliorate symptoms associated with benign prostatic hyperplasia making it relevant for research on urological and cardiovascular disorders
Apexbio Technology LLC GSK1070916 942918-07-2 50mg
GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways
Apexbio Technology LLC GSK1070916 942918-07-2 5mg
GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways
Apexbio Technology LLC Pyoluteorin 25683-07-2 1mg
Pyoluteorin (CAS 25683-07-2) is a secondary metabolite exhibiting antibiotic and antifungal activities via inhibition of targeted pathogens including soilborne plant pathogens Pyoluteorin functions as a signaling molecule promoting its own biosynthesis and modulating secondary metabolite pathways in Pseudomonas fluorescens In vitro studies indicate pyoluteorin induces apoptosis in human triple-negative breast cancer MDA-MB-231 cells Current data do not report precise IC50 values for specific targets or models Based on its pharmacological profile pyoluteorin is applicable in research on microbial interactions control of plant pathogens investigation of bacterial communication and studies involving triple-negative breast cancer
Apexbio Technology LLC Pyoluteorin 25683-07-2 5mg
Pyoluteorin (CAS 25683-07-2) is a secondary metabolite exhibiting antibiotic and antifungal activities via inhibition of targeted pathogens including soilborne plant pathogens Pyoluteorin functions as a signaling molecule promoting its own biosynthesis and modulating secondary metabolite pathways in Pseudomonas fluorescens In vitro studies indicate pyoluteorin induces apoptosis in human triple-negative breast cancer MDA-MB-231 cells Current data do not report precise IC50 values for specific targets or models Based on its pharmacological profile pyoluteorin is applicable in research on microbial interactions control of plant pathogens investigation of bacterial communication and studies involving triple-negative breast cancer
Medchemexpress LLC 2-methoxyestradiol | 362-07-2 | >99.5% | 1 ML
2-Methoxyestradiol is an endogenous metabolite of 17β-estradiol used in research to investigate apoptosis, antiproliferative, and antiangiogenic effects. Supplied as a 10 mM, 1 mL stock solution in DMSO, it is intended for use in in vitro and preclinical assays studying microtubule disruption and angiogenesis.
- High purity suitable for research-grade experiments.
- Supplied as a ready-to-use 10 mM solution in DMSO for immediate assay use.
- Appropriate for in vitro cell biology and preclinical antiangiogenesis studies.
- Stable when stored frozen; follow storage recommendations to avoid degradation.
Medchemexpress LLC 2-methoxyestradiol | 362-07-2 | >98.0% | 50 MG
2-Methoxyestradiol is an endogenous metabolite of 17β-estradiol used in research as an apoptosis inducer and angiogenesis inhibitor. It destabilizes microtubules and can generate reactive oxygen species; supplied as a high-purity solid for analytical and cell-based studies.
- Endogenous estradiol metabolite with pro-apoptotic activity.
- Inhibits angiogenesis and disrupts microtubule function.
- High purity suitable for analytical and cell-based assays.
- Soluble in DMSO; practically insoluble in water and ethanol.
- Available in small research pack sizes for laboratory use.
Medchemexpress LLC 2-methoxyestradiol | 362-07-2 | 99.8% | 5MG
2-methoxyestradiol | 362-07-2 | 99.8% | 5MG
Medchemexpress LLC 2-methoxyestradiol | 362-07-2 | 99.8% | 100 MG
2-methoxyestradiol is an endogenous metabolite of 17β-estradiol used as a research reagent with apoptosis-inducing and antiangiogenic activity. Supplied as a high-purity solid for analytical and biological research applications.
- High purity suitable for analytical work
- Available in research quantities, including 100 MG
- Used in apoptosis and antiangiogenesis studies
- Soluble in DMSO for solution preparation
- Intended for research use only
Apexbio Technology LLC MLR 1023 41964-07-2 5mg
MLR 1023 (CAS 41964-07-2) also known as Tolimidone functions as an allosteric activator of Lyn kinase by binding to a non-catalytic site on the target protein thereby enhancing kinase activity In vitro studies indicate an EC50 value of approximately 63 nM for the allosteric activation of Lyn kinase MLR 1023 is widely utilized as a research tool to elucidate Lyn kinase-mediated signaling cellular functions and related pathological mechanisms Its application extends to investigations of kinase pathway modulation and potential pharmacological intervention points in disease models