Pyridines and derivatives
TARGETMOL CHEMICALS INC SI-113 10MG
Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades. Purity 98.81%
Medchemexpress LLC SI-109 | 2429877-30-3 | 99.0% | 10 MG
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) that exhibits antitumor activity. It effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). This compound has been utilized, along with an analog of the CRBN ligand lenalidomide, to design the PROTAC STAT3 degrader SD-36.
- Potent STAT3 SH2 domain inhibitor
- Exhibits antitumor activity
- Inhibits transcriptional activity of STAT3
- Used in the design of PROTAC STAT3 degrader SD-36
- Exerts moderate growth inhibitory activity in MOLM-16 cells
- Solid, white to off-white appearance
- Shipped with dry ice
- Store at -80°C, under nitrogen
Medchemexpress LLC SI-109 | 2429877-30-3 | >99.91% | 25 MG
SI-109 is a potent inhibitor of the STAT3 SH2 domain, exhibiting antitumor activity by effectively inhibiting the transcriptional activity of STAT3. It has been utilized in the design of the PROTAC STAT3 degrader SD-36. This compound exerts moderate growth inhibitory activity in MOLM-16 cells. It is for research use only and not intended for human use.
- Potent STAT3 SH2 domain inhibitor
- Exhibits antitumor activity
- Inhibits transcriptional activity of STAT3
- Utilized in PROTAC STAT3 degrader design
- Moderate growth inhibitory activity in MOLM-16 cells
Medchemexpress LLC SI-W052 | 2572552-60-2 | 98.0% | 434.89 | 5 MG
SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, thereby suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). It shows promise for research related to Alzheimer's disease (AD)-associated neuroinflammation.
- Orally active and brain-penetrant
- Selective small-molecule inhibitor targeting mTOR and TEX264
- Activates autophagy by inhibiting mTOR phosphorylation
- Enhances TEX264 expression to promote ER turnover
- Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
Cambridge Isotope Laboratories 440mL Lecture bottle CGA 110/180 aluminum-silicon-bronze valve angle ea
440mL Lecture bottle CGA 110/180 aluminum-silicon-bronze valve angle ea
Medchemexpress LLC Si-W052 | 2572552-60-2 | 98.0% | 434.89 g·mol⁻¹ | C20H19ClN2O5S | 10 MG
SI-W052 is an orally active, brain-penetrant small-molecule inhibitor that selectively targets mTOR and TEX264 to activate autophagy and promote endoplasmic reticulum turnover. It inhibits mTOR phosphorylation and reduces LPS-induced release of inflammatory cytokines, supporting research into neuroinflammation and Alzheimer's-associated pathways.
- Orally active and brain-penetrant.
- Selective inhibitor of mTOR and TEX264.
- Activates autophagy via inhibition of mTOR phosphorylation.
- Enhances TEX264 expression to promote endoplasmic reticulum turnover.
- Reduces LPS-induced release of inflammatory cytokines such as TNF-α and IL-6.
- Supplied as a high-purity solid with defined storage conditions for stability.
Medchemexpress LLC SI-2 hydrochloride | 1992052-49-9 | 98.1% | 301.77 g/mol | C15H16ClN5 | 1 ML
SI-2 hydrochloride (EPH 116 hydrochloride) is a small-molecule inhibitor of the steroid receptor coactivator-3 (SRC-3) protein-protein interaction used for research applications. The compound is provided as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL), and is characterized for in vitro and in vivo studies with reported purity and storage recommendations.
- Potent SRC-3 inhibitor with low-nanomolar activity.
- Supplied as solid and 10 mM solution in DMSO (1 mL).
- High reported purity (98.06%).
- Molecular weight approximately 301.77 g/mol.
- Stable with recommended sealed storage and low-temperature solvent storage.
Medchemexpress LLC SRC-3-IN-2 (SI-12 6c) | 3074959-44-4 | 96.32% | 319.28 | 50 MG
SRC-3-IN-2 (SI-12 6c) is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor with antitumor activity.
- Orally active steroid receptor coactivator 3 (SRC-3) inhibitor.
- Exhibits antitumor activity.
Medchemexpress LLC SI-2 hydrochloride | 1992052-49-9 | MFCD30290164 | 98.1% | 301.77 g/mol | C15H16ClN5 | 25 MG
SI-2 hydrochloride is the hydrochloride salt of a small-molecule SRC-3 protein-protein interaction inhibitor. It selectively reduces SRC-3 transcriptional activity and protein levels, induces breast cancer cell death at low nanomolar IC50 (3-20 nM), and has demonstrated tumor growth inhibition in MDA-MB-468 mouse models with improved toxicity and pharmacokinetic properties and acceptable oral availability.
- Selective SRC-3 inhibitor with low-nanomolar cytotoxicity.
- Demonstrated tumor growth inhibition in mouse models.
- Improved toxicity and pharmacokinetic profile suitable for in vivo studies.
- Soluble in DMSO at 5 mg/mL; recommends sealed, cold storage.
- Stable in buffers at pH ≥ 5 with minimal short-term degradation at low pH.
- Analytical purity approximately 98% (LCMS), suitable for research use.
Medchemexpress LLC Src-3-in-2 (SI-12 6c) | 3074959-44-4 | 96.3% | 319.28 | C15H12F3N5 | 10 MG
SRC-3-IN-2 (SI-12 6c) is an orally active inhibitor of steroid receptor coactivator 3 (SRC-3) with reported antitumor activity. It is supplied as a research-grade solid and as a DMSO solution for biochemical and cellular studies.
- Orally active SRC-3 inhibitor with reported antitumor activity.
- Suitable for biochemical and cellular assays.
- Available as a solid and 10 mM solution in DMSO.
- Purity approximately 96.3%.
- Molecular weight 319.28; formula C15H12F3N5.
- Supplied in small research pack sizes, including 10 mg.
Medchemexpress LLC M-PEG-triethoxysilane (MW 5000) | 98.0% | COCCOCCNC(NCCC[Si](OCC)(OCC)OCC)=O.[n].[MW 5000] | 100 MG
M-PEG-triethoxysilane (MW 5000) is a PEG-based PROTAC linker intended for research use only. It can be utilized in the synthesis of PROTACs, which leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
![Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384381-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 25 MG
SI-W052 is an orally active, brain-penetrant, and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, thereby suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer's disease (AD)-associated neuroinflammation.
- Orally active
- Brain-penetrant
- Selective small-molecule inhibitor targeting mTOR and TEX264
- Activates autophagy by inhibiting mTOR phosphorylation
- Enhances TEX264 expression to promote ER turnover
- Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
- Promising for research of Alzheimer's disease (AD)-associated neuroinflammation
![Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385295-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 100 MG
SI-W052 is an orally active, brain-penetrant, and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer's disease (AD)-associated neuroinflammation.
- Orally active and brain-penetrant
- Selective small-molecule inhibitor targeting mTOR and TEX264
- Activates autophagy by inhibiting mTOR phosphorylation
- Enhances TEX264 expression to promote ER turnover
- Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
- Promising for research of Alzheimer's disease (AD)-associated neuroinflammation
![Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000383985-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-chloro-2-[(2-furanylmethyl)amino]-5-[[methyl(phenylmethyl)amino]sulfonyl]- | 2572552-60-2 | 98.0% | 434.89 | 50 MG
SI-W052 is an orally active, brain-penetrant, and selective small-molecule inhibitor targeting mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, thereby suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer's disease (AD)-associated neuroinflammation.
- Orally active
- Brain-penetrant
- Selective small-molecule inhibitor targeting mTOR and TEX264
- Activates autophagy by inhibiting mTOR phosphorylation
- Enhances TEX264 expression to promote ER turnover
- Suppresses LPS-induced release of inflammatory factors (TNF-α, IL-6)
- Promising for research of Alzheimer's disease (AD)-associated neuroinflammation