Pyrimidines And Derivatives
Sigma Aldrich calcium salicylate
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
2-Anilinopyrimidine-5-carboxylic acid, 97%, Thermo Scientific™
CAS: 450368-25-9 Molecular Formula: C11H9N3O2 Molecular Weight (g/mol): 215.21 MDL Number: MFCD09864415 InChI Key: ZPIYMRAJXNMUPE-UHFFFAOYSA-N Synonym: 2-phenylamino pyrimidine-5-carboxylic acid,5-pyrimidinecarboxylicacid, 2-phenylamino,2-anilino-5-pyrimidinecarboxylic acid,2-anilinopyrimidine-5-carboxylic acid PubChem CID: 23509722 IUPAC Name: 2-anilinopyrimidine-5-carboxylic acid SMILES: OC(=O)C1=CN=C(NC2=CC=CC=C2)N=C1
Methyl 5-bromopyrimidine-2-carboxylate, 95%, Thermo Scientific Chemicals
CAS: 89581-38-4 Molecular Formula: C6H5BrN2O2 Molecular Weight (g/mol): 217.02 MDL Number: MFCD11111606 InChI Key: XILAKTMDKMVJQV-UHFFFAOYSA-N Synonym: methyl 5-bromopyrimidine-2-carboxyate,methyl-5-bromo-2 pyrimidine carboxylate,5-bromo-pyrimidine-2-carboxylic acid methyl ester,2-pyrimidinecarboxylic acid, 5-bromo-, methyl ester,2-pyrimidinecarboxylicacid, 5-bromo-, methyl ester,5-bromopyrimidine-2-carboxylic acid methyl ester,acmc-20dmbr,pubchem21032,methyl5-bromopyrimidine-2-carboxylate,methyl 5-bromanylpyrimidine-2-carboxylate PubChem CID: 45790831 IUPAC Name: methyl 5-bromopyrimidine-2-carboxylate SMILES: COC(=O)C1=NC=C(Br)C=N1
Ethyl 2-chloropyrimidine-5-carboxylate, 97%
CAS: 89793-12-4 Molecular Formula: C7H7ClN2O2 Molecular Weight (g/mol): 186.595 MDL Number: MFCD09863164 InChI Key: IEMKQRSOAOPKRJ-UHFFFAOYSA-N Synonym: 2-chloro-pyrimidine-5-carboxylic acid ethyl ester,2-chloro-5-ethoxycarbonyl pyrimidine,ethyl-2-chloropyrimidine-5-carboxylate,ethyl 2-chloro-pyrimidine-5-carboxylate,5-pyrimidinecarboxylic acid, 2-chloro-, ethyl ester,ethyl2-chloropyrimidine-5-carboxylate,acmc-209r2w,ksc663i8r,ethyl 2-chloranylpyrimidine-5-carboxylate,2-chloro-5-pyrimidinecarboxylic acid ethyl ester PubChem CID: 10487815 IUPAC Name: ethyl 2-chloropyrimidine-5-carboxylate SMILES: CCOC(=O)C1=CN=C(N=C1)Cl
Medchemexpress LLC Calcium Phytate | 3615-82-5 | 250 MG
Calcium phytate is an insoluble phosphorus-containing compound commonly found in plant-based foods such as cereals and legumes. It can be present in feces and has shown properties to alleviate lead poisoning.
- Found extensively in plant-based foods such as cereals and legumes
- Can be present in feces
- Alleviates lead poisoning
- Reduces weight loss in lead poisoning models
- Reduces lead accumulation in the liver and kidneys
- Reverses toxic effects of lead on liver and kidney weights
Medchemexpress LLC Mitiglinide calcium | 145525-41-3 | 98.8% | 334.44 | 250 MG
Mitiglinide calcium, an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. It is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel) and can be used for the research of type 2 diabetes.
- Inhibits Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) in COS-1 cells.
- Suppresses the increase in plasma glucose levels after a meal load and the area under the curve for plasma glucose levels (AUCglucose).
Medchemexpress LLC Prohexadione calcium | 127277-53-6 | 98.1% | 251.27 | 250 MG
Prohexadione calcium (BX-112) is a plant growth regulator that inhibits gibberellin biosynthesis in plants. This product is for research use only and not sold to patients.
- Inhibits gibberellin biosynthesis in plants
- Inhibits JMJD2A demethylase activity at 1 mM
- Induces the differentiation of mouse neurospheres into neurons (at 1-2 mM concentration)
- Alleviates saline-alkali stress in soybean seedlings when sprayed at 100 mg/L
- Induces structural resistance to fire blight infection in potted apple trees
Medchemexpress LLC Calcium mesoxalate trihydrate | 21085-60-9 | MFCD30541333 | 98.0% | 210.15 | C3H6CaO8 | 250 MG
Calcium mesoxalate trihydrate is a research-grade inorganic salt used in biochemical and cellular studies. It has reported biological activities including promotion of B cell proliferation and potential anti-diabetic effects, and is supplied as a high-purity, dry solid suitable for assay development and exploratory pharmacology.
- Trihydrate form of calcium mesoxalate
- Reported to promote B cell proliferation and show potential anti-diabetic activity
- Provided as a high-purity solid (98.0%)
- Molecular formula C3H6CaO8 and molecular weight 210.15
- Available in small research quantities, including 250 mg
- Suitable for biochemical assays and exploratory pharmacology
Apexbio Technology LLC CUDC-907,5mg CAS# 1339928-25-4
CUDC-907 is a dual-acting inhibitor of HDAC and PI3K with IC50 values of 1.7/5.0/1.8/2.8 nM (HDAC1/2/3/10) and 19/54/39 nM (PI3K).[1]The phosphoinositide 3-kinases (PI3Ks) contain three classes of PI3K each with its own distinct lipid products and specific substrate. They are a family of lipid kinases that regulates a wide range of pathway by propagating intracellular signaling cascades. PI3K phosphorylates the 3’-OH group of phosphatidylinositols. This activated AKT, the protein Ser/Thr-kinase, by recruiting them to the cell membrane. The PI3K/AKT signaling pathway is critical in cancer, because it promotes cell growth and survival. The studies have proved that PI3K pathway plays an important role in cancer progression and treatment for lung cancers, breast cancer.[2, 3] Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC PRT062607 Hydrochloride,5mg CAS# 1370261-97-4
PRT062607 Hydrochloride is a highly selective and novel SYK inhibitor with IC50 value of 1 nM. Spleen tyrosine kinase (SYK) is a cytoplasmic tyrosine kinase and primarily expressed in hematopoietic cells including B-cells.PRT062607 Hydrochloride is an orally bioavailable SYK inhibitor and its affinity for SYK is at least 80-fold greater than other kinases. In NHL cell lines, PRT062607 Hydrochloride inhibits SYK activation and induces caspase dependent apoptosis. Also, PRT062607 Hydrochloride inhibited SYK and caused apoptosis of the tumor B-cell line [1]. Other sizes are also available. Please inqury us for quote.
Enzo Life Sciences PI-103 (1mg). CAS: 371935-74-9
Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo. Alternative name: 3-(4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (5mg/ml; warm). Long Term Storage: -20°C.
Apexbio Technology LLC Cerdulatinib (PRT062070),10mg CAS# 1198300-79-6
Cerdulatinib (PRT062070) is a potent and selective inhibitor of Syk and JAK.[1]The JAK/STAT cascade, which has been implicated in hematopoiesis and cytokine signaling, is present in humans and flies. Worms. The SYK/ZAP70 kinases play an important role in human T and B cell signaling.[3]Cerdulatinib can induce apoptosis via down-regulation of MCL1 protein and PARP cleavage. Through the inhibition of RB phosphorylation and down-regulation of cyclin E,the Cerdulatinib can also block G1/S transition and cause cell cycle arrest. Further analyses of the cell signaling activities showed that STAT3 phosphorylation was sensitive to inhibition by cerdulatinib in ABC cell lines while phosphorylation of SYK, PLCg2, AKT and ERK is reported to be sensitive to inhibition by cerdulatinib in GCB cell lines.[2] Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC HY-103668A 5mg Medchemexpress, SSD114 hydrochloride CAS: Purity:>98%
Medchemexpress, HY-103668A 5mg SSD114 HCl CAS: SSD114 hydrochloride is a novel GABAB receptor positive allosteric modulator. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC CJ-42794(Synonyms: CJ42794, CJ 42794, CJ-42794, EP4 antagonist CJ-42794, CAS 847728-01-2), 250mg, CAS: 847728-01-2.
CJ-42794 (CAS 847728-01-2) is a potent and selective antagonist targeting prostaglandin E receptor subtype 4 (EP4) It exhibits high affinity for EP4 receptors (Ki 3 16 nM) with significantly lower potency at EP2 receptors (Ki 631 nM) and negligible affinity for EP1 or EP3 By blocking EP4-mediated signaling CJ-42794 prevents prostaglandin E2-induced intracellular cAMP elevation thereby reversing PGE2-dependent inhibition of inflammatory responses such as lipopolysaccharide-induced TNF- secretion In animal models administration of CJ-42794 delays gastric ulcer healing through suppression of VEGF expression and angiogenesis This compound serves as a valuable tool for investigating EP4-associated physiological and pathological processes
Medchemexpress LLC HY-108335 5mg Medchemexpress, Sipatrigine CAS:130800-90-7 Purity:>98%
Medchemexpress, HY-108335 5mg Sipatrigine CAS:130800-90-7 Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.