Pyrimidines And Derivatives
Sigma Aldrich Methyl glycolate
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Medchemexpress LLC Dodecaethylene glycol | 6790-09-6 | 99.9% | C24H50O13 | 250 MG
Dodecaethylene glycol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules that comprise two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. These compounds function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- Used in the synthesis of PROTACs
- Functions by leveraging the intracellular ubiquitin-proteasome system
- Selectively degrades specific target proteins
- For research use only
Medchemexpress LLC Methoxypolyethylene glycol maleimide (MW 5000) | 99126-64-4 | 99.9% | 5000 | 250 MG
Methoxypolyethylene glycol maleimide (MW 5000) is a protein PEGylation reagent.
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: -20°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
Medchemexpress LLC Ethylene dimethanesulfonate | 4672-49-5 | 98.0% | 50 MG
Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. It demonstrates selective pro-apoptotic effects on LCs.
- Mild alkylating agent
- Non-volatile methanesulfonic diester of ethylene glycol
- Selective pro-apoptotic effects on LCs
Medchemexpress LLC Mal-PEG6-acid | 518044-42-3 | ≥98.0% | 250 MG
Mal-PEG6-acid is a polyethylene glycol-based linker employed in the creation of protein degraders.
- It is a PEG-based linker.
- It can be used in the synthesis of protein degraders.
- It has high purity (≥98.0%).
Medchemexpress LLC Dodecylheptaglycol | 3055-97-8 | MFCD00043065 | 98.1% | 494.70 g/mol | C26H54O8 | 250 MG
Dodecylheptaglycol is a PEG-based PROTAC linker used as a flexible spacer in the synthesis of proteolysis-targeting chimeras and other bifunctional molecules. Its heptaethylene glycol backbone with a dodecyl terminus provides balanced hydrophilicity and lipophilicity for linker design.
- PEG-based heptaethylene glycol linker suitable for linker design.
- Balances solubility and hydrophobicity for diverse conjugation strategies.
- High purity (>98%) for research-grade synthesis.
- Defined molecular weight (494.70 g/mol) for predictable spacer length.
- Available in multiple pack sizes for small- to medium-scale synthesis.
- Stable under recommended storage conditions to preserve integrity.
Medchemexpress LLC Ethylene dimethanesulfonate | 4672-49-5 | 98.0% | 100 MG
Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. It exhibits selective pro-apoptotic effects on LCs.
- Mild alkylating agent
- Non-volatile methanesulfonic diester
- Selective pro-apoptotic effects on LCs
- White to off-white solid appearance
- Disrupts epididymal function (in vivo)
Medchemexpress LLC 5-Cholanic acid 250mg
5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
Medchemexpress LLC 5-Cholanic acid 1g
5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
Medchemexpress LLC 5-Cholanic acid 500mg
5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
Medchemexpress LLC 5-Cholanic acid 50mg
5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
Medchemexpress LLC m-PEG6-azide 250mg | 1043884-49-6 | 321.37 g/mol | C13H27N3O6 | 250 MG
m-PEG6-azide is a six-unit monomethyl polyethylene glycol linker bearing a terminal azide group. It is used as a PEG spacer in bioconjugation and antibody-drug conjugate linker synthesis, where the azide enables click chemistry (for example, CuAAC) and other azide-based conjugations.
- Six-unit monomethyl PEG with a terminal azide functional group.
- Enables click chemistry and azide-based bioconjugation.
- Used as a PEG spacer in ADC linker synthesis and general bioconjugation.
- High purity (98.0%) for consistent conjugation performance.
- Colorless to light yellow liquid; store at -20°C (pure) for long-term stability.
- Supplied as a 250 mg pack suitable for small-scale synthesis.
Medchemexpress LLC Nh-bis-peg2 | 54384-47-3 | MFCD00239212 | 97.0% | 193.24 g·mol⁻¹ | C8H19NO4 | 250 MG
NH-bis-PEG2 is a non-cleavable, two-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs). It provides a short, flexible spacer with a terminal amino (NH) functionality suitable for bioconjugation and linker construction.
- Non-cleavable two-unit PEG linker suitable for ADC and PROTAC synthesis.
- Provides a short, flexible spacer with terminal NH for bioconjugation.
- CAS number 54384-47-3.
- Molecular formula C8H19NO4; molecular weight 193.24 g·mol⁻¹.
- Purity 97.0%.
- Storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Packaged quantity: 250 MG.