Pyrroles
Medchemexpress LLC Atorvastatin (hemicalcium trihydrate) | 344920-08-7 | 100 MG
Atorvastatin hemicalcium trihydrate is an orally active inhibitor of HMG-CoA reductase. Its primary function is to effectively lower blood lipid levels. Additionally, it has been observed to inhibit human SV-SMC proliferation and invasion, with IC50 values of 0.39 μM and 2.39 μM, respectively.
- Orally active HMG-CoA reductase inhibitor
- Effectively decreases blood lipids
- Inhibits human SV-SMC proliferation and invasion
- Demonstrates IC50s of 0.39 μM (proliferation) and 2.39 μM (invasion) in human SV-SMC
Apexbio Technology LLC Sunitinib 557795-19-4 10mM (in 1mL DMSO)
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Medchemexpress LLC Nemonoxacin malate | 951163-60-3 | MFCD11865196 | 98.3% | 505.52 | C24H31N3O9 | 5 MG
Nemonoxacin malate is a nonfluorinated quinolone antibiotic research compound (CAS 951163-60-3) with broad-spectrum activity against Gram-positive, Gram-negative, and atypical pathogens. It has demonstrated activity versus drug-resistant Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus and is used in studies of community-acquired pneumonia.
- High purity (98.3%).
- Molecular weight 505.52 g/mol.
- Molecular formula C24H31N3O9.
- Available in small research quantities (e.g., 5 mg).
- Suitable for in vitro and bacterial infection research.
Medchemexpress LLC (−)-G-Lactone | 43119-28-4 | ≥98.0% | 124.14 | 5 G
(−)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis. For research use only. We do not sell to patients.
- Synthetic intermediate
- Useful for prostaglandins synthesis
Medchemexpress LLC (3S,5S)-Atorvastatin | 501121-34-2 | 95.0% | 50 MG
(3S,5S)-Atorvastatin is an inactive enantiomer of Atorvastatin that activates pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, known for its ability to effectively decrease blood lipids.
- Increases CYP2B and CYP3A mRNA content with equal ability as Atorvastatin.
- Induces luciferase activity with an EC50 of 12.4 μM at 100 μM concentrations.
- Addition to the 2-formylphenylboronic acid (FPBA)/l-tryptophanol mixture enhances l-tryptophanol fluorescence.
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 10mM (in 1mL DMSO)
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Medchemexpress LLC Almotriptan (malate) | 181183-52-8 | 99.5% | 5 MG
Almotriptan (malate) | 181183-52-8 | 99.5% | 5 MG
Medchemexpress LLC Olmesartan lactone impurity | 849206-43-5 | MFCD27978125 | 99.3% | 428.49 g/mol | C24H24N6O2 | 5 MG
Olmesartan lactone impurity is the cyclic ester impurity of olmesartan, provided as a high-purity analytical standard for research, impurity profiling, and method development. The compound has molecular formula C24H24N6O2 and molecular weight 428.49 g/mol, and is supplied in small-mass quantities for laboratory use.
- Reported purity 99.27% (rounded to 99.3%).
- Molecular formula C24H24N6O2; molecular weight 428.49 g/mol.
- Suitable as a reference standard for impurity profiling and analytical method development.
- Available in small pack sizes for analytical testing, such as 5 mg and 10 mg.
- Analytical documents available: data sheet, COA, HNMR, LCMS, and SDS.
Medchemexpress LLC (-)-Corey lactone diol | 32233-40-2 | 172.18 | 25 G
(-)-Corey lactone diol is the reduced form of Corey aldehyde. It can be used as a drug intermediate for the synthesis of Beraprost.
- Reduced form of Corey aldehyde
- Can be used as a drug intermediate
- Building block in chemical synthesis
Cayman Chemical RBromoenol lactone
A selective iPLA2γ inhibitor (IC50 = ~0.6 µM); selective for iPLA2γ over iPLA2β at 20-30 µM
Medchemexpress LLC Olmesartan lactone impurity | 849206-43-5 | MFCD27978125 | 99.3% | C24H24N6O2 | 10MG
Olmesartan lactone impurity is a cyclic ester impurity of olmesartan supplied as an analytical reference standard for impurity profiling, stability studies, and analytical method development. It is a white to off-white solid with high reported purity and specified storage conditions to support long-term stability.
- High purity: 99.27%.
- Molecular formula C24H24N6O2 and molecular weight 428.49 g·mol⁻¹.
- Available in small, measured quantities suitable for analytical use.
- Storage conditions provided for powder and solution to maintain integrity.
- Intended for impurity profiling, stability testing, and method validation.