Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,936 – 1,950 of 5,523 results

1,936

Medchemexpress LLC Mexenone | 1641-17-4 | 99.9% | 200 MG

Mexenone is a potent benzophenone-type UV filter used as a sunscreening agent.

Potent benzophenone-type UV filter.
Used for sunscreening.

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1,937

TARGETMOL CHEMICALS INC ON-01910 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. purity: 99%

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1,938

Medchemexpress LLC (S)-Rasagiline | 185517-74-2 | >98% | C12H13N | 200 MG

(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. It is a highly potent, selective, irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. It also functions as a click chemistry reagent.

Relatively inactive S-enantiomer form of rasagiline
Highly potent, selective, irreversible MAO inhibitor
IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity
Functions as a click chemistry reagent
Contains an alkyne group
Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups

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1,939

Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG

Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.

Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
Elevates full-length SMN protein.
Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
EC50 of 20 nM for SMN.
IC50 of 6.3 μM for hERG.

Pricing & Availability

1,940

eMolecules 57334-35-7 | 5-METHOXY-8-QUINOLINOL | MFCD18414704 | 1g

AstaTech | 5-METHOXY-8-QUINOLINOL | 1g | 273172844 | 76306 | 95.000 | 57334-35-7 | MFCD18414704 | 175.187 | C10H9NO2

If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
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1,941

Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG

VK-II-86 is a carvedilol analogue and a store-overload-induced calcium release (SOICR) inhibitor used as a research chemical to study cardiac arrhythmia mechanisms and calcium homeostasis. It lacks β-adrenoceptor antagonist activity and has been shown to prevent hypokalaemia-induced ventricular arrhythmia by normalizing ion channel activity and repolarization reserve.

Inhibits store-overload-induced calcium release, supporting arrhythmia research.
Lacks β-adrenoceptor antagonist activity, reducing β-blocking confounds in studies.
Reported to normalize calcium homeostasis and repolarization reserve in models.
Solid, light brown to brown appearance and supplied in small milligram quantities.
Molecular weight 420.50 g/mol; formula C25H28N2O4.
High purity (93.3%) suitable for laboratory research applications.

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1,942

Apexbio Technology LLC Sodium Phenylbutyrate 1716-12-7 200mg

Sodium Phenylbutyrate (CAS 1716-12-7) is a small-molecule inhibitor targeting histone deacetylase (HDAC) an enzyme involved in regulating histone acetylation an epigenetic mechanism implicated in cancer progression and cardiac dysfunction In oral squamous cell carcinoma cell lines (CAL27 HSC3 SCC4) Sodium Phenylbutyrate demonstrated dose-dependent cell growth inhibition (IC50 4 091 3 712 and 3 015 mM respectively) and decreased cell viability in a time-dependent manner In a mouse Adriamycin-induced cardiac injury model treatment with Sodium Phenylbutyrate significantly attenuated cardiac enzyme elevations improved cardiac function and increased cardiac MnSOD protein expression and activity Sodium Phenylbutyrate serves as an important research tool for cancer biology and cardiotoxicity studies

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1,943

Medchemexpress LLC B7-H2/ICOSLG protein, rat recombinant, C-His tagged | >95.0% | 500 UG

Recombinant rat B7-H2 (ICOSLG) protein expressed in HEK293 cells and purified for use in binding and functional assays. Supplied lyophilized with a C-terminal His tag, it is intended for research applications studying ICOS-ICOSLG interactions.

Recombinant rat ICOS ligand expressed in HEK293 cells.
C-terminal His tag for detection and purification.
Supplied lyophilized from PBS, pH 7.4.
Purity >95.0% by reducing SDS-PAGE.
Sequence corresponds to residues E25-K261.
Approximate molecular weight 40-60 kDa.
Recommended reconstitution ≥100 μg/mL; store lyophilized at -20°C.
Validated in ELISA with ED50 ≈ 89.92 ng/mL.

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1,944

Apexbio Technology LLC Coenzyme Q10 303-98-0 200mg

Coenzyme Q10 (CAS 303-98-0) is a lipophilic benzoquinone involved in mitochondrial electron transport and cellular energy production It functions as an essential electron carrier within the electron transport chain facilitating ATP synthesis and exhibiting antioxidant properties by mitigating oxidative damage Coenzyme Q10 is frequently studied for its role in cellular metabolism bioenergetics and redox homeostasis Due to its involvement in mitochondrial function it is widely applied in research on metabolic disorders neurodegeneration and cardiovascular diseases The compound is soluble in organic solvents such as chloroform benzene and carbon tetrachloride For optimal stability it should be stored sealed in cool and dry conditions

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1,945

Apexbio Technology LLC EPI-001 227947-06-0 200mg

EPI-001 (CAS 227947-06-0) is a small-molecule inhibitor targeting the amino-terminal domain (NTD) of the androgen receptor (AR) It is designed to inhibit AR transcriptional activation by disrupting protein-protein interactions essential for AR function thus regulating AR-dependent signaling pathways EPI-001 exerts its biological activity primarily through inhibition of the AR NTD transactivation In cell-based studies EPI-001 demonstrates suppression of AR-mediated transcriptional activation with an IC50 value of approximately 6 M Based on these pharmacological properties EPI-001 holds research potential in prostate cancer particularly in castration-resistant prostate cancer models

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1,946

Apexbio Technology LLC Nucleozin 341001-38-5 200mg

Nucleozin (CAS 341001-38-5) is a small-molecule inhibitor targeting influenza A virus nucleoprotein (NP) It is designed to block NP nuclear accumulation thereby inhibiting a critical step in the viral replication cycle Nucleozin exerts its biological activity primarily through inducing NP aggregation and preventing its nuclear localization In in vitro studies using MDCK cells infected with influenza A variants Nucleozin demonstrates antiviral inhibition with EC50 values of 0 069 M for A/WSN/33 (H1N1) 0 16 M for H3N2 and 0 33 M for Vietnam/1194/04 (H5N1) Based on these pharmacological properties Nucleozin holds research potential in influenza antiviral development

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1,947

Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 99.7% | 156.20 | 5g

Methyl phenyl sulfone is a drug impurity

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1,948

Medchemexpress LLC Dacomitinib | 1110813-31-4 | 469.94 | 200 MG

Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases. It exhibits IC50s of 6 nM, 45.7 nM, and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

Targets EGFR and apoptosis
Inhibits JAK/STAT signaling and protein tyrosine kinase/RTK pathways
Available as a solid
Molecular formula: C24H25ClFN5O2
Recommended storage for powder: -20°C (3 years) or 4°C (2 years)
Recommended storage in solvent: -80°C (2 years) or -20°C (1 year)

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1,949

Medchemexpress LLC Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG

Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG

Pricing & Availability

1,950

Medchemexpress LLC 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | 252916-29-3 | MFCD09743433 | >98.0% | 310.3 g/mol | C18H18N2O3 | 200 MG

Orantinib is a small-molecule, orally bioavailable receptor tyrosine kinase inhibitor that selectively inhibits VEGFR2, PDGFRβ, and FGFR1, blocking receptor autophosphorylation and angiogenesis. It is used in preclinical and clinical research for tumor growth inhibition and antiangiogenic studies. Chemical formula C18H18N2O3; molecular weight ~310.3 g/mol; CAS 252916-29-3.

Multi-target inhibition of VEGFR2, PDGFRβ, and FGFR1.
Orally bioavailable small molecule suitable for in vivo and in vitro studies.
Blocks receptor autophosphorylation and inhibits angiogenesis.
Applied in oncology and angiogenesis research applications.
High purity material appropriate for research use.

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Quinolines and derivatives

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Medchemexpress LLC Mexenone | 1641-17-4 | 99.9% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S)-Rasagiline | 185517-74-2 | >98% | C12H13N | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC B7-H2/ICOSLG protein, rat recombinant, C-His tagged | >95.0% | 500 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 99.7% | 156.20 | 5g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dacomitinib | 1110813-31-4 | 469.94 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More