Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | ≥97.0% | C22H46N4O10 | 1 G
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Azido-PEG10-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs consist of two different ligands connected by a linker, leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group for CuAAc and SPAAC reactions
- Appearance is colorless to off-white liquid
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Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | 97.0% | C22H46N4O10 | 50 MG
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Azido-PEG10-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, which can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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eMolecules 58794-09-5 | 7-bromoisoquinoline | AA Blocks LLC | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 5g | 410166201
7-bromoisoquinoline | AA Blocks LLC | 58794-09-5 | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 5g | 410166201
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eMolecules 58794-09-5 | 7-bromoisoquinoline | AA Blocks LLC | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 1g | 410166200
7-bromoisoquinoline | AA Blocks LLC | 58794-09-5 | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 1g | 410166200
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Medchemexpress LLC Ranolazine | 95635-55-5 | 99.8% | 200 MG
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Ranolazine (CVT 303) is an anti-angina drug that inhibits the late phase of inward sodium current (INa and IKr) and acts as an antianginal agent. It is also a partial fatty acid oxidation (FAO) inhibitor. This product is for research use only and not sold to patients.
- Inhibits late phase of inward sodium current (INa and IKr)
- Acts as an antianginal agent
- Partial fatty acid oxidation (FAO) inhibitor
- Does not affect heart rate or blood pressure
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Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | 99.00% | 10 MG
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Sulfo DBCO-amine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Utilizes intracellular ubiquitin-proteasome system to degrade target proteins
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TARGETMOL CHEMICALS INC MORACIN C 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Moracin C a natural compound found in Morus mesozygia Morus alba var. multicaulis is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells. purity: 99%
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Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.3% | 450.60 | 25 MG
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Romaciclib monohydrochloride is an ATP-competitive and selective CDK8 inhibitor. It inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, and has a Kd of 3 nM for CDK8. It weakly inhibits CDK9 but shows no significant activity against CDK1, 2, 4, 6, 5, or 7. This compound inhibits phosphorylation of STAT1 S727 and STAT5 S726, demonstrating anti-tumor activity.
- ATP-competitive and selective CDK8 inhibitor.
- Inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes.
- Weakly inhibits CDK9 and shows no obvious activity against several other CDKs (CDK1, 2, 4, 6, 5, 7).
- Inhibits phosphorylation of STAT1 S727 and STAT5 S726.
- Possesses anti-tumor activity.
- Decreases IRF9 and STAT1 mRNA expression and mitogen-induced IER expression.
- Inhibits growth of AML tumors in a dose-dependent manner in SCID mice.
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Medchemexpress LLC 3,6,9,12,15,18-Hexaoxaeicosane-1,20-diamine | 76927-70-3 | ≥97.0% | 324.41 | 1 G
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Amino-PEG6-amine is a PEG-based (6 units) PROTAC linker that can be utilized in the synthesis of PROTACs. It is intended for research use only.
- PEG-based (6 units) PROTAC linker
- Can be used in the synthesis of PROTACs
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Medchemexpress LLC m-PEG6-Amine | 184357-46-8 | ≥97.0% | 25 G
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m-PEG6-Amine is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It also functions as a cleavable ADC linker for the creation of antibody-drug conjugates (ADCs). PROTACs are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker. ADCs, on the other hand, consist of an antibody attached to a cytotoxin through an ADC linker.
- Functions as a PEG-based PROTAC linker
- Acts as a cleavable ADC linker
- Used in the synthesis of PROTACs
- Applied in the synthesis of antibody-drug conjugates (ADCs)
- Enables selective protein degradation via the ubiquitin-proteasome system (for PROTACs)
- Targets cleavable linkers and PEGs (in vitro)
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Ambeed 1 3 4Oxadiazol2amine
1,3,4-Oxadiazol-2-amine, 3775-60-8, 95%
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569606 MIDECAMYCIN-200MG
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Ambeed 2Chloro9Hpurine
2-Chloro-9H-purine, 1681-15-8, 97%
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Medchemexpress LLC Propidium (iodide) | 25535-16-4 | 99.7% | 5 MG
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Propidium Iodide (PI) is a nuclear staining agent that stains DNA. It is an analogue of ethidine bromide, emitting red fluorescence when embedded in double-stranded DNA. PI cannot pass through living cell membranes but can pass through damaged cell membranes to stain the nucleus. It is commonly used in detecting apoptosis or necrosis and in flow cytometry analysis.
- Stains DNA
- Emits red fluorescence when embedded in double-stranded DNA
- Used in detection of apoptosis or necrosis
- Commonly used in flow cytometry analysis
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Medchemexpress LLC Mal-amido-PEG9-acid | 2112731-43-6 | 99.5% | 250 MG
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Mal-amido-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. These PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only and has not been fully validated for medical applications.
- PEG-based linker
- Used in synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Utilizes ubiquitin-proteasome system
- Contains two ligands connected by a linker
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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