Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 1 ML
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Quinine hydrochloride dihydrate (Qualaquin) is an orally active anti-malarial agent and a potassium channel inhibitor. It inhibits WT mouse Slo3 (KCa5.1) channel currents with an IC50 of 169 μM.
- Used in anti-malarial studies.
- Inhibits WT mouse Slo3 (KCa5.1) channel currents.
- Shows antiviral activity against DENV (Dengue virus) in human HepG2 cell lines.
- May have tumor-suppressing effects on skin cancer in Swiss albino mice.
- Impacts the antioxidant defense system in rat testicular tissue.
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Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 10 G
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Quinine hydrochloride dihydrate is an orally active compound primarily used in anti-malarial studies. It functions as a potassium channel inhibitor, specifically targeting WT mouse Slo3 (KCa5.1) channel currents. This compound has also demonstrated effects against Dengue virus proliferation in HepG2 cell lines and exhibited some tumor-suppressing activity in skin cancer models.
- Acts as a potassium channel inhibitor
- Inhibits WT mouse Slo3 (KCa5.1) channel currents
- Inhibits DENV proliferation and cytostatic effects in HepG2 cell lines
- Reduces viral DENV RNA and protein levels
- Shows tumor-suppressing effects on skin cancer in mice
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.4% | 100 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM and can induce apoptosis. It can be used for malaria research.
- Molecular weight: 324.42
- Formula: C20H24N2O2
- Appearance: Solid
- Color: White to off-white
- Structure classification: Alkaloids, Quinoline Alkaloids
- Initial source: Plants other families
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Selleck Chemical LLC Mefloquine HCl S4420-500mg
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Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation used as an antimalarial drug
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Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 25 G
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Cinchonidine is a cinchona alkaloid found in plants such as *Cinchona officinalis*. It serves as a building block in asymmetric synthesis and exhibits antimalarial activities.
- Acts as a weak inhibitor of the serotonin transporter (SERT)
- Used as a building block in asymmetric synthesis
- Exhibits antimalarial activities
- Available in solid, white to off-white appearance
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Selleck Chemical LLC Quinine S4495-25mg
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Quinine an alkaloid derived from the bark of the cinchona tree is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5 1) channel currents evoked by voltage pulses to 100 mV with IC50 of 169 M
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Apexbio Technology LLC Quinidine 56-54-2 250mg
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Quinidine (CAS 56-54-2) is a small-molecule inhibitor targeting sodium (Na ) and potassium (K ) ion channels It is designed to inhibit these ion channel currents thereby modulating cardiac electrophysiological processes Quinidine exerts its biological activity primarily through inhibition of Na and K currents In in vitro studies quinidine demonstrates inhibitory activity with an IC50 of approximately 41 M on the transient outward potassium current (Ik) at a membrane potential of 0 mV Based on these pharmacological properties quinidine holds research potential in the fields of cardiac electrophysiology ion channel pharmacology drug metabolism and drug-drug interaction mechanisms
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568048 IMIQUIMOD-MALEATE-100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000692238 IMIQUIMOD MALEATE 10MM/1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000743885 RESIQUIMOD 50MG
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Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 200 MG
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Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It exhibits antiviral and antitumor effects in vivo. This product is used for research related to external genital, perianal warts, cancer, and COVID-19.
- Immune response modifier
- Selective toll-like receptor 7 (TLR7) agonist
- Exhibits antiviral and antitumor effects in vivo
- Used for research of external genital, perianal warts, cancer, and COVID-19
- Can be used to induce psoriasis models
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Medchemexpress LLC Imiquimod Maleate 10Mmx1Ml Sol | HY-B0180B-10MMX1ML
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Imiquimod Maleate 10Mmx1Ml Sol
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Apexbio Technology LLC Resiquimod (R-848) 144875-48-9 100mg
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Resiquimod (R-848) is an immunomodulatory small molecule structurally related to imiquimod It functions primarily by activating immune responses via inducing cytokine release In vitro studies with human peripheral blood mononuclear cells (PBMC) indicate that Resiquimod promotes dose-dependent production of cytokines including interferon-alpha (IFN- ) tumor necrosis factor (TNF) interleukin-1 (IL-1 ) and interleukin-6 (IL-6) Mechanistically Resiquimod increases intracellular IL-1 levels and both monocytes and B-cells respond by secreting IFN upon stimulation In addition it elevates mRNA expression of IFN- TNF and IL-8 in treated PBMC relative to untreated controls Resiquimod demonstrates antiviral and antitumor activities in preclinical animal models frequently utilized as an immune response potentiator and Toll-like receptor (TLR) agonist in biomedical investigations (IC50 values typically range in low micromolar)
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Medchemexpress LLC Imiquimod (hydrochloride) | 99011-78-6 | 10 MM 1 ML
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Imiquimod hydrochloride, also known as R 837 hydrochloride, is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. This compound exhibits antiviral and antitumor effects in vivo, making it valuable for various research applications.
- Used for research of external genital, perianal warts, cancer, and COVID-19
- Can induce psoriasis models
- Exhibits antiviral effects in vivo
- Exhibits antitumor effects in vivo
- Acts as a selective toll-like receptor 7 (TLR7) agonist
- Functions as an immune response modifier
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Apexbio Technology LLC Imiquimod 99011-02-6 100mg
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Imiquimod (CAS 99011-02-6) is a small-molecule agonist targeting Toll-like receptor 7 (TLR7) It is designed to activate TLR7 thereby modulating innate immune responses Imiquimod exerts its biological activity primarily through induction of cytokines such as interferon-gamma and interleukin-12 while suppressing IL-4 and IL-5 thus affecting cellular immunity In in vitro studies imiquimod demonstrates TLR7 activation with an EC50 of approximately 2 1 M and exhibits an anti-proliferative effect mediated by opioid growth factor (OGF) with an IC50 of 2 M Based on these pharmacological properties imiquimod holds research potential in cancer inflammatory diseases and dermatologic conditions including basal cell carcinoma superficial squamous cell carcinoma actinic keratosis and external genital warts
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