Quinolines and derivatives
TARGETMOL CHEMICALS INC CIS-5-DODECENOIC ACID 100MG
Also available in 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position. purity: 99%
Medchemexpress LLC Zm241385 | 139180-30-6 | 99.5% | 337.34 | 200 MG
Zm241385 | 139180-30-6 | 99.5% | 337.34 | 200 MG
Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | 99.9% | 434.65 | 5 MG
Tacalcitol monohydrate promotes normal bone growth by regulating calcium ions. It also inhibits cancer cell proliferation and migration. This compound is suitable for research related to inflammation, cancer, and skin diseases.
- Promotes normal bone growth through calcium ion regulation.
- Inhibits cancer cell proliferation and migration.
- Inhibits the synthesis of IL-6 and IL-8 in nasal polyp fibroblast cultures in a dose-dependent manner.
- Induces cell differentiation in normal human keratinocytes.
- Inhibits the growth of normal and psoriatic human keratinocytes.
- Inhibits DNA synthesis in normal human keratinocytes.
- Strongly reduces the proliferation of human glioblastoma.
- Inhibits human glioblastoma migration.
- Significantly inhibits TPA-induced cutaneous inflammation and improves epidermal differentiation in hairless mice.
Apexbio Technology LLC BMS-626529 701213-36-7 200mg
BMS-626529 is a small molecule inhibitor designed to block HIV-1 attachment to host cells Its mechanism involves binding to the viral envelope protein gp120 thereby hindering gp120-mediated interactions with CD4 receptors on CD4 T cells and preventing initial viral entry In cell-based assays BMS-626529 shows strain-specific antiviral activity with IC50 values mostly below 10 nM and notably low picomolar IC50 against highly susceptible HIV-1 isolates This molecule serves as a research tool to investigate HIV-1 entry inhibition and virus-host interaction mechanisms in biomedical studies
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 200mg
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Medchemexpress LLC Gemifloxacin mesylate | 210353-53-0 | MFCD08277637 | 99.59% | 1 ML
Gemifloxacin mesylate is an orally active, broad-spectrum quinolone antibacterial antibiotic. It works by inhibiting DNA synthesis through the inhibition of DNA gyrase and Topoisomerase IV activities. It has been utilized in the research of respiratory tract infections.
- Inhibits DNA synthesis by targeting DNA gyrase and Topoisomerase IV activities
- Exhibits potent antibacterial activities against gram-positive bacteria in vitro, particularly Streptococci and Staphylococci
- Higher antibacterial activity than Moxifloxacin against Streptococcus pneumoniae with a MIC90 of 0.06 μg/mL
- Highly potent antibacterial activity against Penicillin-resistant strains of S. pneumoniae with a MIC90 of 0.03 μg/mL
Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 200 MG
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
- Potent inhibitor of PI3Kα/δ with IC50 of 3 nM
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation and downstream targets of Akt signaling
- Shows high efficacy of antitumor activity in ZD1839-resistant non-small cell lung cancer (NSCLC) cell lines (A549 and H460)
- Highly efficacious in combination with U0126 in inducing cell growth inhibition, G0-G1 arrest, and cell apoptosis
- Reduces secreted VEGF after hypoxic/anoxic exposure
- Leads to tumor stasis in animal models
- Results in tumor regressions during treatment leading to enhanced antitumor responses
- Reduces tumor growth and PI3K and HIF-1 pathway activity in tumor-bearing mice
Medchemexpress LLC Palmitoylethanolamide | 544-31-0 | MFCD00020562 | 99.86% | 299.49 | 200 MG
Palmitoylethanolamide (Standard) is the analytical standard for Palmitoylethanolamide, an active endogenous compound. It is intended for research and analytical applications, and can be used for preventing virus infection of the respiratory tract.
- Analytical standard for Palmitoylethanolamide.
- Intended for research and analytical applications.
- Can be used for preventing virus infection of the respiratory tract.
- High purity of 99.86%.
- Available in multiple quantities for various research needs.
- Suitable for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
Medchemexpress LLC ASP-9521 | 1126084-37-4 | 98.0% | 330.42 | 200 MG
ASP-9521 is a potent, selective, and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. It shows more than 100-fold selectivity for AKR1C3 over the isoform AKR1C2. This inhibitor suppresses AD-dependent PSA production and cell proliferation in LNCaP-AKR1C3 cells, and inhibits AD-induced intratumoural T production in CWR22R xenografts for up to 24 hours.
- Potent and selective AKR1C3 inhibitor
- Orally available
- High selectivity over AKR1C2
- Suppresses AD-dependent PSA production and cell proliferation
- Inhibits AD-induced intratumoural T production
- Inhibitory effect maintained for 24 hours
Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | MFCD30343546 | 97.0% | 324.41 | 250 MG
Amino-PEG6-amine is a PROTAC linker, based on a PEG (polyethylene glycol) chain with 6 units, which can be utilized in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based (6 units) PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC Potassium clavulanate cellulose | 61177-45-5 | 98.0% | 238.26 | 200 MG
Potassium clavulanate cellulose is a mixture of potassium clavulanate and cellulose. It acts as a bacterial β-lactamase inhibitor. Clavulanate potassium, a form of Clavulanic acid, combats bacteria resistant to penicillins and other antibiotics. When combined with amoxicillin, it can be used for research on various bacterial infections such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and skin infections.
- Acts as a bacterial β-lactamase inhibitor
- Combats bacteria resistant to penicillins and other antibiotics
- Suitable for research on various bacterial infections
- Can be combined with amoxicillin for infection research
Medchemexpress LLC 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaheptatriacontan-1-amine | 1977493-48-3 | >98.0% | 559.69 | C25H53NO12 | 50 MG
m-PEG12-amine is a methoxy-terminated polyethylene glycol (PEG) linker with a terminal primary amine used as a hydrophilic spacer for bioconjugation, PROTAC, and ADC linker synthesis. It provides aqueous solubility and a reactive amine for standard coupling chemistries.
- Methoxy-terminated PEG12 spacer provides hydrophilicity.
- Terminal primary amine enables standard coupling chemistry.
- High purity: >98.0%.
- Molecular weight approximately 559.69.
- Appearance: colorless to off-white solid-liquid mixture.
- Storage: store at -20°C, protect from light, under nitrogen.
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 10mg, CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Medchemexpress LLC 3,6,9,12,15,18,21,24,27,30-decaoxadotriacontane-1,32-diamine | 928292-69-7 | MFCD28122962 | ≥97.0% | 500.62 g/mol | C22H48N2O10 | 50 MG
Amino-PEG10-amine is a polyethylene glycol (PEG10) diamine linker bearing primary amino groups at both termini. It is used as a hydrophilic, flexible spacer for PROTAC synthesis, bioconjugation, and crosslinking, providing improved solubility and coupling handle accessibility.
- Provides two terminal primary amines for covalent coupling.
- PEG10 spacer increases solubility in aqueous media.
- High purity suitable for research and synthesis (≥97% by NMR).
- Flexible spacer for linker design in PROTAC and bioconjugation applications.
- Stable when stored protected from light at recommended temperatures.