Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Lobeglitazone sulfate | 763108-62-9 | 99.6% | 578.61 | 100 MG
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Lobeglitazone sulfate is a novel thiazolidinedione and an orally active agonist for PPAR with EC50 values of 137.4 nM for PPARγ and 546.3 nM for PPARα. It acts as an inhibitor for the ERK/JNK/Smad/NF-κB signaling pathway.
- Exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties.
- Increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells.
- Inhibits NO generation and pro-inflammatory cytokines in LPS-stimulated BMDMs.
- Inhibits TGF-β1-induced expression of α-SMA and fibronectin, showing anti-fibrotic properties.
- Inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells.
- Demonstrates anti-atherosclerotic property in ApoE-/- mouse aortic atherosclerosis models.
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eMolecules 6964-62-1 | 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol | MFCD08823776 | 50mg
Ambeed | 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol | 50mg | 525100416 | A183021 | 6964-62-1 | MFCD08823776 | 340.426 | C23H20N2O
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eMolecules LEUPEPTIN . HEMISULFATE 5MG
5000191507 LEUPEPTIN . HEMISULFATE 5MG
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eMolecules 5466-27-3 | ChemScene | Ethyl 2-hydroxyquinoline-4-carboxylate | 250mg | 654744479 | CS-0208320 | MFCD02041443 | 217.224 | C12H11NO3
ChemScene | Ethyl 2-hydroxyquinoline-4-carboxylate | 250mg | 654744479 | CS-0208320 | 5466-27-3 | MFCD02041443 | 217.224 | C12H11NO3
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Apexbio Technology LLC RU.521 2262452-06-0 5mg
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RU 521 (CAS 2262452-06-0) is a selective inhibitor of cyclic GMP-AMP synthase (cGAS) an enzyme responsible for synthesizing cGAMP upon recognition of cytosolic double-stranded DNA By interfering with cGAS-mediated cGAMP production RU 521 suppresses activation of the type I interferon signaling pathway Experimental studies demonstrate that RU 521 reduces cGAS-dependent signal transduction and interferon responses in reporter assays containing double-stranded DNA In macrophages derived from Aicardi-Gouti res syndrome mouse models RU 521 lowers basal interferon expression This compound is a valuable tool for investigating cGAS-dependent innate immune pathways
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Selleck Chemical LLC Bemnifosbuvir Hemisulfate-5MG
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Bemnifosbuvir Hemisulfate (AT-527 RG-6422 RO 7496998) is a hemi-sulfate salt of AT-511 AT-511 is a potent inhibitor of SARS-CoV-2 with an EC90 of 0 47 M
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Selleck Chemical LLC Proflavine Hemisulfate S4236-50mg
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Proflavine Hemisulfate is a topical antiseptic by interchelating DNA thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands
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Ambeed AMBEED
5000866827 4-BROMONAPHTHALEN-2-AMINE 1GR
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Ambeed AMBEED
5000887569 4-AMINOQUINOLINE-2-ONE 100MG
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Ambeed AMBEED
5000890844 S-6-BROMOCHROMAN-4-AMINE 100MG
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Apexbio Technology LLC H 89 2HCl 130964-39-5 200mg
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H 89 2HCl (CAS 130964-39-5) is a small-molecule inhibitor targeting cyclic AMP-dependent protein kinase (PKA) It exhibits a Ki of approximately 48 nM toward PKA and demonstrates substantial selectivity compared to related kinases such as PKG (about 10-fold) PKC MLCK calmodulin kinase II and casein kinases (approximately 500-fold) In PC12D cells H 89 at micromolar concentrations suppresses forskolin-induced phosphorylation events and neurite outgrowth without altering intracellular cAMP levels Due to its selective inhibitory profile H 89 is widely utilized in cell signaling studies examining cAMP-dependent pathways
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Sigma Aldrich Fine Chemicals Biosciences 8-Quinolinol puriss. p.a., ACS reagent, reag. Ph. Eur., >=99% (perchloric acid titration) | 148-24-3 | MFCD00006807 | 100G
8-Quinolinol puriss. p.a., ACS reagent, reag. Ph. Eur., >=99% (perchloric acid titration) | Purity: >=99% (perchloric acid titration) | Mol Wt: 145.16 | 148-24-3 | MFCD00006807 | 100G
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Medchemexpress LLC Lenvatinib | 417716-92-8 | 99.8% | 1 G
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Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor. It inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, demonstrating potent antitumor activities. This compound shows antiproliferative activity and growth inhibition in various cell lines.
- Inhibits VEGFR2, VEGFR3, and VEGFR1
- Inhibits PDGFRα, PDGFRβ, and FGFR1
- Inhibits KIT and RET
- Demonstrates antiproliferative activity
- Available as a solid form
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Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 200mg
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Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
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Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | MFCD13184757 | 99.9% | 434.65 g/mol | C27H46O4 | 10 MG
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Tacalcitol monohydrate is a vitamin D3 analog (1,24(R)-dihydroxyvitamin D3 monohydrate) used as a research reagent to modulate vitamin D receptor (VDR) signaling and calcium regulation. It is applied in studies of bone metabolism, skin disorders, inflammation, and oncology to probe VDR-mediated pathways.
- High purity (99.85%).
- Vitamin D3 analog that modulates vitamin D receptor activity.
- Applicable to in vitro and in vivo research on bone metabolism, skin disease, inflammation, and cancer.
- Supplied as a monohydrate solid for consistent dosing.
- Molecular weight 434.65 g/mol; formula C27H46O4.
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