Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Mefloquine (hydrochloride) | 51773-92-3 | 99.98% | 414.77 | 500 MG
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Mefloquine hydrochloride is a quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. It acts as a K+ channel antagonist and is suitable for research in malaria, systemic lupus erythematosus, and cancer. It selectively inhibits prostate cancer cell growth and shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine. Animal studies indicate it can reverse lower vertebral cancellous bone volume.
- Quinoline antimalarial agent
- Anti-SARS-CoV-2 entry inhibitor
- K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM
- Selectively inhibits prostate cancer cell growth with an IC50 of ~10 μM
- Induces hyperpolarization of mitochondrial membrane potential (MMP) and ROS generation
- Shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine
- Can be used for malaria, systemic lupus erythematosus and cancer research
- Reverses lower vertebral cancellous bone volume and bone formation in old mice
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![eMolecules Medchem Express / Ethylhydrocupreine (hydrochloride) / 25mg / 673358916 / HY-136429A / / 3413-58-9 / [null] / 376.930 / C21H29ClN2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502448325.PNG-250.jpg)
eMolecules Medchem Express / Ethylhydrocupreine (hydrochloride) / 25mg / 673358916 / HY-136429A / / 3413-58-9 / [null] / 376.930 / C21H29ClN2O2
Medchem Express / Ethylhydrocupreine (hydrochloride) / 25mg / 673358916 / HY-136429A / / 3413-58-9 / [null] / 376.930 / C21H29ClN2O2
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Sigma Aldrich Fine Chemicals Biosciences Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | 51773-92-3 | MFCD00797519 | 100MG
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 414.77 | 51773-92-3 | MFCD00797519 | 100MG
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Medchemexpress LLC Quinidine hydrochloride monohydrate | 6151-40-2 | 99.97% | 100 MG
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Quinidine hydrochloride monohydrate is an anti-arrhythmic agent that also acts as a potent blocker of K+ channels. It is intended for research use only.
- Potent K+ channel blocker.
- Aids in electrophysiological research.
- Available in solid and solution forms for various experimental needs.
- Comes with detailed documentation for quality assurance.
- Referenced in numerous scientific publications.
- Offers diverse applications for in vitro and in vivo studies.
- Easily soluble in common laboratory solvents.
- Supports accurate dosage calculations for experimental protocols.
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Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 100 G
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Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is a building block used in asymmetric synthesis in organic chemistry. It acts as a weak inhibitor of the serotonin transporter (SERT) and exhibits antimalarial activities.
- Derived from *Cinchona officinalis* and *Gongronema latifolium*
- Used as a building block in asymmetric synthesis
- Weak inhibitor of the serotonin transporter (SERT)
- Exhibits antimalarial activities
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Medchemexpress LLC Mefloquine | 53230-10-7 | 100.0% | 378.31 | 5 MG
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Mefloquine is an orally active and potent quinoline antimalarial agent, also functioning as an anti-SARS-CoV-2 entry inhibitor and a K+ channel (KvQT1/minK) antagonist. It is suitable for various research applications.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist with an IC50 of approximately 1 μM.
- Suitable for malaria research.
- Suitable for systemic lupus erythematosus research.
- Suitable for cancer research.
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TARGETMOL CHEMICALS INC Quinidine hydrochloride monohy
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Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Quinidine hydrochloride monohydrate is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and decreases automaticity. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. Purity 94.72%
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eMolecules Medchem Express / Mefloquine (hydrochloride) / 100mg / 446268425 / HY-17437A / / 51773-92-3 / MFCD22208579 / 414.780 / C17H17ClF6N2O
Medchem Express / Mefloquine (hydrochloride) / 100mg / 446268425 / HY-17437A / / 51773-92-3 / MFCD22208579 / 414.780 / C17H17ClF6N2O
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Medchemexpress LLC Mefloquine hydrochloride | 51773-92-3 | 99.98% | 414.77 | 1 ML
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Mefloquine hydrochloride | 51773-92-3 | 99.98% | 414.77 | 1 ML
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Medchemexpress LLC Mefloquine | 53230-10-7 | 99.96% | 378.31 | 50 MG
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Mefloquine (Standard) is the analytical standard of Mefloquine, intended for research and analytical applications. It is an orally active and potent quinoline antimalarial agent and an anti-SARS-CoV-2 entry inhibitor. Mefloquine also acts as a K+ channel (KvQT1/minK) antagonist with an IC50 of approximately 1 μM. It can be utilized for malaria, systemic lupus erythematosus, and cancer research.
- Analytical standard of Mefloquine.
- Intended for research and analytical applications.
- Orally active and potent quinoline antimalarial agent.
- Anti-SARS-CoV-2 entry inhibitor.
- K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM.
- Applicable for malaria, systemic lupus erythematosus, and cancer research.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
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Medchemexpress LLC Mefloquine | 53230-10-7 | 100.0% | 378.31 g·mol-1 | C17H16F6N2O | 10 MG
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Mefloquine is an orally active quinoline antimalarial agent used in biomedical research. It has reported activity as an inhibitor of SARS-CoV-2 entry and as a K+ channel antagonist (IC50 ≈1 μM). Supplied as a solid for research use only; not intended for clinical or human therapeutic use.
- High purity (HPLC 99.96%).
- Chemical formula C17H16F6N2O; molecular weight 378.31 g·mol-1.
- CAS number 53230-10-7.
- Common uses: malaria, autoimmune disease, and oncology research.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 | C19H22N2O | 5g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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Apexbio Technology LLC Cinchonidine 485-71-2 500mg
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Cinchonidine (CAS 485-71-2) is a small-molecule inhibitor targeting the serotonin transporter (SERT) It is designed to inhibit SERT function thereby modulating serotonin uptake activity Cinchonidine exerts its biological activity primarily through SERT inhibition In in vitro studies Cinchonidine demonstrates inhibitory activity with IC50 values of 330 M for dSERT and 4 2 36 196 and 15 M for hSERT and its mutants I172M S438T and Y95F respectively Based on these pharmacological properties Cinchonidine holds research potential in serotonin transporter regulation and malaria research
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AdipoGen Quinine HCl dihydrate
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Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
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Selleck Chemical LLC Hydroquinidine S4658-100mg
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Hydroquinidine (Dihydroquinidine Hydroconchinine Hydroconquinine Dihydroquinine) is an antiarrhythmic agent
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