Quinolines and derivatives
Medchemexpress LLC Quizartinib | 950769-58-1 | 99.1% | 200 MG
Quizartinib is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor. It inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells, with IC50s of 4.2 nM and 1.1 nM respectively. This compound can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader, and it induces apoptosis. It is intended for research use only.
- Orally active
- Highly selective and potent type II FLT3 tyrosine kinase inhibitor
- Inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Forms PROTAC FLT3 degrader when linked to VHL ligand
- Induces apoptosis
Medchemexpress LLC BML-284 | 853220-52-7 | 100.0% | 350.37 | 200 MG
BML-284 is a potent and cell-permeable Wnt signaling activator. It induces TCF-dependent transcriptional activity with an EC50 of 700 nM.
- Potent Wnt signaling activator
- Cell-permeable
- Induces TCF-dependent transcriptional activity
![Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243212.png-250.jpg)
Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG
TAK-715 is an orally active, potent p38 MAPK inhibitor used in research to probe p38α signaling and related pathways; it also inhibits casein kinase I (CK1δ/ε) and has demonstrated efficacy in preclinical inflammation models.
- Potent p38α inhibition (IC50 7.1 nM) with reduced activity against p38β (IC50 200 nM).
- Reported inhibition of CK1δ/ε and modulation of Wnt/β-catenin signaling.
- Chemical formula C24H21N3OS; molecular weight 399.51 g/mol.
- High reported purity (99.76%).
- Soluble in DMSO (≈50 mg/mL) with suggested protocols for in vivo formulation.
- Powder stable at -20°C for extended storage; solvent stocks stable at -80°C.
TARGETMOL CHEMICALS INC LEMINOPRAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Leminoprazole is an orally available H+K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. purity: 99%
Medchemexpress LLC Tirapazamine | 27314-97-2 | 99.0% | 178.15 | 200 MG
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single- and double-strand breaks in DNA, base damage, and cell death. It is an anticancer and bioreductive agent that can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.
- Selective cytotoxicity for hypoxic cells
- Induces single- and double-strand breaks in DNA
- Induces base damage and cell death
- Enhances cytotoxic effects of ionizing radiation in hypoxic cells
Sigma Aldrich Fine Chemicals Biosciences 8-Quinolinol N-oxide 98% | 1127-45-3 | MFCD00006739 | 10G
8-Quinolinol N-oxide 98% | Purity: 98% | Mol Wt: 161.16 | 1127-45-3 | MFCD00006739 | 10G
Sigma Aldrich Fine Chemicals Biosciences 5,7-Dichloro-8-quinolinol 99% | 773-76-2 | MFCD00006786 | 5G
5,7-Dichloro-8-quinolinol 99% | Purity: 99% | Mol Wt: 214.05 | 773-76-2 | MFCD00006786 | 5G
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 200mg, CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Apexbio Technology LLC Pemetrexed 150399-23-8 200mg
Pemetrexed (CAS 150399-23-8) is a folate antagonist that targets multiple enzymes involved in the de novo synthesis of purine and pyrimidine nucleotides including thymidylate synthase (TS) dihydrofolate reductase (DHFR) glycinamide ribonucleotide formyltransferase (GARFT) and aminoimidazole carboxamide ribonucleotide formyltransferase (AICARFT) Structurally related to the antifolate compound lometrexol Pemetrexed disrupts nucleotide biosynthesis and subsequently inhibits DNA replication in proliferating cells It has demonstrated enzymatic inhibition across several pathways though exhibits limited cytotoxic activity in a range of tumor cell types such as non-small cell lung cancer mesothelioma breast colorectal cervical head and neck and bladder cancers This compound is widely used in preclinical studies of folate pathway inhibition and antimetabolite chemotherapy research
Medchemexpress LLC (S,R,S)-AHPC-CO-C9-acid | 2172819-78-0 | 95.0% | 628.82 | 100 MG
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. This product is for research use only and has not been fully validated for medical applications.
- E3 ligase ligand-linker conjugate
- Can be connected to ligand for protein to form PROTACs
- White to off-white solid appearance
- Target: E3 ligase ligand-linker conjugates
- Pathway: PROTAC
- Antiproliferative activity against human NCI-H69 cells
- Soluble in DMSO
Apexbio Technology LLC JNJ-26481585 875320-29-9 200mg
JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment
Apexbio Technology LLC Regorafenib 755037-03-7 200mg
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Medchemexpress LLC Sulfo-Cy5.5 azide | 1955527-41-9 | MFCD28334525 | ≥95.0% | 999.16 | C44H50N6O13S4 | 10 MG
Sulfo-Cy5.5 Azide is a water-soluble, far-red fluorescent click-chemistry reagent containing an azide functional group for covalent labeling of peptides, proteins, and oligonucleotides. It is suitable for imaging applications and reacts via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC); excitation is ~673 nm with emission ~707 nm.
- Water-soluble fluorescent dye suitable for aqueous labeling reactions.
- Azide functional group enables CuAAC and SPAAC click chemistries.
- Far-red emission for reduced background and deep-tissue imaging.
- High purity (≥95.0%) for reliable labeling results.
- Soluble in DMSO at 50 mg/mL with gentle warming and sonication.
- Store protected from light; in solvent store at -80°C for long term.
Medchemexpress LLC Pomalidomide-5-C9-NH2 (hydrochloride) | 2925306-22-3 | 98.7% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Pomalidomide-5-C9-NH2 hydrochloride is a pomalidomide-derived ligand for the cereblon (CRBN) E3 ubiquitin ligase, supplied as the hydrochloride salt for research use. It is primarily used as a CRBN-recruiting moiety in the design and synthesis of PROTACs and other targeted protein degradation tools, and is provided in small milligram quantities with high reported purity.
- Ligand for cereblon (CRBN) E3 ubiquitin ligase.
- Designed for use as a CRBN-recruiting moiety in PROTAC synthesis.
- Provided as the hydrochloride salt for improved stability and handling.
- High reported purity (98.68%) suitable for research applications.
- Available in small milligram quantities for medicinal chemistry workflows.
eMolecules 252917-06-9 | CHIR-99021 | TargetMol | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039
CHIR-99021 | TargetMol | 252917-06-9 | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039