Quinolines and derivatives
Medchemexpress LLC Tacalcitol monohydrate | 93129-94-3 | 99.9% | 434.65 | 5 MG
Tacalcitol monohydrate promotes normal bone growth by regulating calcium ions. It also inhibits cancer cell proliferation and migration. This compound is suitable for research related to inflammation, cancer, and skin diseases.
- Promotes normal bone growth through calcium ion regulation.
- Inhibits cancer cell proliferation and migration.
- Inhibits the synthesis of IL-6 and IL-8 in nasal polyp fibroblast cultures in a dose-dependent manner.
- Induces cell differentiation in normal human keratinocytes.
- Inhibits the growth of normal and psoriatic human keratinocytes.
- Inhibits DNA synthesis in normal human keratinocytes.
- Strongly reduces the proliferation of human glioblastoma.
- Inhibits human glioblastoma migration.
- Significantly inhibits TPA-induced cutaneous inflammation and improves epidermal differentiation in hairless mice.
Medchemexpress LLC Vinburnine | 4880-88-0 | 99.8% | 200 MG
Vinburnine is a vinca alkaloid and a metabolite of vincamine, which acts as a vasodilator. It is intended for research use only.
- Allosteric modulator of muscarinic receptors M1-M4.
- Exhibits an anti-amnesia effect in a scopolamine-induced mouse amnesia model.
- Promotes erythrocyte glycolysis, increases erythrocyte ATP and 2,3-diphosphoglycerol content, and improves erythrocyte deformability and tissue oxygen delivery.
Medchemexpress LLC Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG
Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG
Medchemexpress LLC B7-H2/ICOSLG Human 10ug
B7-H2/ICOSLG Protein Human (HEK293 His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells ICOSLG is a number of the B7 family of co-stimulatory molecules
eMolecules 36404-88-3 | 2-CHLORO-PYRIDINE-3-CARBALDEHYDE | AstaTech | MFCD01315308 | 141.550 | C6H4ClNO | 97.000 | Clc1ncccc1C=O | 25g | 112525679
2-CHLORO-PYRIDINE-3-CARBALDEHYDE | AstaTech | 36404-88-3 | MFCD01315308 | 141.550 | C6H4ClNO | 97.000 | Clc1ncccc1C=O | 25g | 112525679
eMolecules 74124-79-1 | N,N'-Disuccinimidyl carbonate | Chem-Impex | MFCD00009767 | 256.170 | C9H8N2O7 | 99.000 | O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 100g | 112443063
N,N'-Disuccinimidyl carbonate | Chem-Impex | 74124-79-1 | MFCD00009767 | 256.170 | C9H8N2O7 | 99.000 | O=C(ON1C(=O)CCC1=O)ON1C(=O)CCC1=O | 100g | 112443063
Medchemexpress LLC Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]- | 312636-16-1 | 99.25% | 302.78 | 200 MG
SKI-II is an orally active and synthetic inhibitor of sphingosine kinase (SK) activity. It is intended for research use only and causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. It inhibits cell proliferation and promotes β-catenin degradation.
- Orally active and synthetic inhibitor of sphingosine kinase (SK) activity
- IC50 values: 78 μM for SK1 and 45 μM for SK2
- Causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation
- Inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway
- Promotes the degradation of β-catenin by enhancing Wnt5A
- Shows synergistic effect with DDP in human gastric carcinoma SGC7901/DDP cell line
- Reduces S1P concentrations in plasma in mice with chronic administration
- Reduces tumor growth in mice bearing solid tumor models
Medchemexpress LLC Piperidolate | 82-98-4 | 99.3% | 200 MG
Piperidolate is an antimuscarinic that inhibits intestinal cramps induced by acetylcholine in rats and dogs. It is intended for research and analytical applications.
- Inhibits intestinal cramps
- Targets muscarinic acetylcholine receptors (mAChR)
- Relevant for neurological and neurodegenerative diseases
- Useful for GPCR/G protein and neuronal signaling research
TARGETMOL CHEMICALS INC BAY-2402234 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. purity: 99%
Medchemexpress LLC Rivastigmine (tartrate) | 129101-54-8 | MFCD03700731 | 99.03% | 400.42 | 50 MG
Rivastigmine tartrate is an orally active and potent cholinesterase (ChE) inhibitor. It inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). This compound can pass the blood-brain barrier (BBB) and is used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Reduces LPS-induced TNF-α and IL-6 in vitro
- Improved behavioral impairments caused by Aluminum in male Wistar albino rats
- Reduced IL-6 concentration in BALB/c OlaHsd male mice with acute colitis
Apexbio Technology LLC Cy5.5 alkyne (non-sulfonated) 25mg
Cy5 5 alkyne non-sulfonated is a near-infrared fluorescent cyanine derivative equipped with an alkyne functional group for click chemistry applications Through copper-catalyzed azide-alkyne cycloaddition (CuAAC) it forms covalent conjugates with azide-containing biomolecules metabolites or small-molecule ligands Cy5 5 alkyne non-sulfonated is primarily soluble in organic solvents aqueous solutions containing organic co-solvent such as DMSO may be used during conjugation Based on these chemical properties Cy5 5 alkyne non-sulfonated holds research potential in labeling nucleic acids peptides proteins lipids and other biomolecules for biomedical imaging tissue distribution evaluation and related pharmaceutical research applications
Apexbio Technology LLC PF-2545920 1292799-56-4 200mg
PF-2545920 is a small-molecule inhibitor targeting phosphodiesterase 10A (PDE10A) It is designed to selectively inhibit PDE10A thereby modulating neuronal cAMP and cGMP signaling within cortico-striato-thalamic circuits PF-2545920 exerts its biological activity primarily through selective inhibition of PDE10A In in vitro studies PF-2545920 demonstrates potent inhibitory activity with an IC50 value of 0 37 nM In experimental mouse models it increases striatal cGMP levels at doses around 1 mg/kg Based on these pharmacological properties PF-2545920 holds research potential in the investigation of PDE10A-associated neurobiology and neuropsychiatric conditions such as schizophrenia
eMolecules 1952360-91-6 | (Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 686069702
(Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | 1952360-91-6 | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 686069702
![eMolecules 15788-16-6 | 1H-Benzimadazole-5-carboxylic acid | Oakwood Chemicals | MFCD00011555 | 162.148 | C8H6N2O2 | 95.000 | OC(=O)c1ccc2[nH]cnc2c1 | 250mg | 486558625](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000190342.jpg-250.jpg)
eMolecules 15788-16-6 | 1H-Benzimadazole-5-carboxylic acid | Oakwood Chemicals | MFCD00011555 | 162.148 | C8H6N2O2 | 95.000 | OC(=O)c1ccc2[nH]cnc2c1 | 250mg | 486558625
1H-Benzimadazole-5-carboxylic acid | Oakwood Chemicals | 15788-16-6 | MFCD00011555 | 162.148 | C8H6N2O2 | 95.000 | OC(=O)c1ccc2[nH]cnc2c1 | 250mg | 486558625