Quinolines and derivatives

Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000405190 S R S -AHPC-ME DIH 5G

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Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 100 MG

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Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It demonstrates antiviral and antitumor effects in vivo and is used in research for external genital and perianal warts, cancer, and COVID-19. It appears as a white to off-white solid.

• Molecular weight: 356.38
• Formula: C18H20N4O4
• Ships at room temperature in continental US
• Store at 4°C, sealed, away from moisture
• When in solvent, store at -80°C for 6 months or -20°C for 1 month
• Soluble in DMSO (25 mg/mL) and H2O (2 mg/mL)
• Targets TLR7 and HSV-1
• Used to induce psoriasis models

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Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 5mg

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[Ser25] Protein Kinase C (19-31) (CAS 136795-05-6) is an oligopeptide derived from the pseudosubstrate regulatory domain (amino acids 19-31) of Protein Kinase C alpha (PKC ) modified by substitution of alanine with serine at residue 25 Its sequence is Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val with a molecular weight of 1559 82 and molecular formula C67H118N26O17 It acts as a PKC substrate peptide enabling in vitro measurement of kinase enzymatic activity via serine phosphorylation PKC enzymes participate in diverse cellular processes including adhesion transformation cell cycle control and calcium signaling making this peptide an important tool for kinase activity studies and intracellular signaling research

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Apexbio Technology LLC AMG-900 945595-80-2 200mg

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AMG-900 (CAS 945595-80-2) is a small-molecule inhibitor targeting Aurora kinases a group of serine/threonine kinases crucial for mitosis regulation It exhibits potent ATP-competitive inhibitory activity against all three Aurora kinase isoforms resulting in suppression of Aurora-A and Aurora-B autophosphorylation events AMG-900 induces disruption of cellular mitotic processes leading to cell cycle arrest and subsequent apoptotic cell death Preclinically AMG-900 demonstrates activity across multiple tumor cell lines including multidrug-resistant and taxane-resistant variants and inhibits tumor growth in mouse xenograft models suggesting utility for cancer research

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000772784 1 1 2-TRIMETHYL-3-4 5G

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Apexbio Technology LLC Bindarit 130641-38-2 200mg

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Bindarit (CAS 130641-38-2) also known as AF-2838 is a synthetic small-molecule inhibitor targeting the CC chemokines MCP-1 (CCL2) MCP-2 (CCL8) and MCP-3 (CCL7) By suppressing the transcription and production of MCP proteins Bindarit reduces monocyte chemoattraction and inflammation In vitro data indicate that Bindarit inhibits LPS-induced MCP-1 synthesis in monocytes with an IC50 around 172 M and selectively decreases MCP expression without impacting unrelated cytokines such as IL-6 or IL-8 Animal studies demonstrate its potential to reduce inflammatory cell infiltration vascular smooth muscle cell proliferation and neointimal hyperplasia in rodent injury models highlighting its value for inflammation and cardiovascular disease research

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Medchemexpress LLC 7-Hydroxycarbostyril | 70500-72-0 | 99.05% | 161.16 | 25 G

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7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) is a quinolinone derivative. This compound is utilized in the synthesis of brexpiprazole, an orally active antipsychotic agent that functions as a partial agonist for both human 5-HT1A and dopamine D2L receptors.

• A quinolinone derivative.
• Used for the synthesis of brexpiprazole.
• High purity: 99.05%.
• For research use only.

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Aobchem AOBCHEM

5000918392 5-FLUORO-2-ISOPROPOXY-4-METHYL

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Aobchem AOBCHEM

5000918393 5-FLUORO-2-ISOPROPOXY-4-METHYL

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Medchemexpress LLC MSA-2 | 129425-81-6 | 99.8% | 294.32 | 200 MG

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MSA-2 is a potent and orally available non-nucleotide STING agonist that binds to STING as a noncovalent dimer with nanomolar affinity. It stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.

• Potent and orally available non-nucleotide STING agonist
• Binds to STING as a noncovalent dimer with nanomolar affinity
• Stimulates interferon-β secretion in tumors
• Induces tumor regression with durable antitumor immunity
• Synergizes with anti-PD-1 in syngeneic mouse tumor models
• Achieves comparable exposure in tumor and plasma
• Exhibits dose-dependent antitumor activity
• Induces elevations of IFN-β, IL-6, and TNF-α in tumors

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eMolecules​ 39061-97-7 | 4-Chloro-3-nitroquinoline | Synthonix - Stock | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 1g | 452564968

4-Chloro-3-nitroquinoline | Synthonix - Stock | 39061-97-7 | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 1g | 452564968

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eMolecules​ Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3

Ambeed (4-Formyl-phenyl)-carbamicacidtert-butylester 250mg 521412715 A164452 0 000 144072-30-0 MFCD06245541 221 256 C12H15NO3

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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.9% | 50 MG

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Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It also acts as a potent α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer activity. Furthermore, it is a calmodulin inhibitor and inhibits P-glycoprotein. This compound is utilized in research for schizophrenia and acts as a reversible inhibitor of influenza virus morphogenesis by interfering with cellular CaM and/or CaM-dependent functions.

• Blocks central dopamine receptors
• Potent α1-adrenergic receptor antagonist
• Potent NUPR1 inhibitor with anticancer activity
• Calmodulin inhibitor
• Inhibits P-glycoprotein
• Utilized in research for schizophrenia
• Acts as a reversible inhibitor of influenza virus morphogenesis

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eMolecules​ 39061-97-7 | 4-Chloro-3-nitroquinoline | Combi-Blocks | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 1g | 388714538

4-Chloro-3-nitroquinoline | Combi-Blocks | 39061-97-7 | MFCD07369246 | 208.600 | C9H5ClN2O2 | 95.000 | [O-][N+](=O)c1cnc2ccccc2c1Cl | 1g | 388714538

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eMolecules​ 58794-09-5 | 7-bromoisoquinoline | AA Blocks LLC | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 1g | 410166200

7-bromoisoquinoline | AA Blocks LLC | 58794-09-5 | MFCD07368661 | 208.058 | C9H6BrN | 0.000 | Brc1ccc2ccncc2c1 | 1g | 410166200

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