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Filtered Search Results
Medchemexpress LLC Azido-PEG1-amine | 464190-91-8 | ≥98.0% | C4H10N4O | 100 MG
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Azido-PEG1-amine is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs utilize two ligands connected by a linker to target an E3 ubiquitin ligase and a protein of interest, facilitating selective degradation via the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Utilized in PROTAC synthesis
- Relevant for cancer targeted therapy
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TARGETMOL CHEMICALS INC PF-04929113 MESYLATE 5MG
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Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PF-04929113 Mesylate (SNX-5422 Mesylate) a prodrug of SNX-2112 is an orally available Hsp90 inhibitor (Kd 41 nM) and also induces Her-2 degradation (IC50 37 nM). purity: 99%
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Apexbio Technology LLC N-Methylnicotinamide 114-33-0 200mg
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N-Methylnicotinamide (CAS 114-33-0) is a methylated derivative of nicotinamide and a primary metabolic product of niacinamide and niacin (vitamin B3) catabolism It does not have a defined therapeutic target or approved clinical use but plays a significant role in biomedical research as an indicator of vitamin B3 status Measurement of urinary N-methylnicotinamide is routinely employed to assess niacin sufficiency and diagnose deficiencies reflecting metabolic function related to NAD/NADP biosynthesis pathways This compound thus serves as a valuable biomarker in nutritional and metabolic research contexts
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Apexbio Technology LLC Regorafenib hydrochloride(Synonyms: Regorafenib HCl, BAY 73-4506, Stivarga, BAY73-4506 hydrochloride, Regorafenib hydrochloride salt), 200mg, CAS: 835621-07-3.
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Regorafenib hydrochloride (CAS 835621-07-3) is an orally bioavailable small molecule inhibitor targeting multiple protein kinases including c-KIT VEGFR2 and B-Raf It inhibits these kinases with IC50 values of approximately 17 nM (c-KIT) 40 nM (VEGFR2) and 69 nM (B-Raf) By blocking kinase signaling Regorafenib hydrochloride effectively interrupts tumor-associated pathways involved in cell proliferation angiogenesis and survival It is widely used in oncology research for studies focused on kinase-mediated tumor growth and vascularization mechanisms
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Medchemexpress LLC 1,4,7-Triazonane | 4730-54-5 | 129.20 | 1 ML
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1,4,7-Triazonane (1,4,7-Triazacyclononane) is an intermediate used in the synthesis of 1,4,7-trifunctionalized derivatives. It serves as a possible reagent for compleximetric titrations due to its high cation-binding selectivity and has applications in metal complexation. The compound exhibits an IC50 of 980 μM against human L3.6pl cells, indicating its cytotoxic potential.
- Intermediate in the synthesis of 1,4,7-trifunctionalized derivatives
- Possible reagent for compleximetric titrations
- Exhibits high cation-binding selectivity
- Applications in metal complexation
- Cytotoxic against human L3.6pl cells (IC50 = 980 μM)
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Sigma Aldrich Fine Chemicals Biosciences Mefloquine hydrochloride >=98% (HPLC), powder | 51773-92-3 | MFCD00797519 | 100MG
Mefloquine hydrochloride >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 414.77 | 51773-92-3 | MFCD00797519 | 100MG
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Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 25mg, CAS: 104821-25-2.
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Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer
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![Medchemexpress LLC Pyrimido[4,5-d]pyrimidinone derivative (1-cyclobutyl, 2,6-dimethylphenyl, 2-methoxy-4-piperazinyl) | 2172617-15-9 | 99.8% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232299.png-250.jpg)
Medchemexpress LLC Pyrimido[4,5-d]pyrimidinone derivative (1-cyclobutyl, 2,6-dimethylphenyl, 2-methoxy-4-piperazinyl) | 2172617-15-9 | 99.8% | 100 MG
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YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor for research use. It displays low-nanomolar activity against SIK isoforms and is supplied as a purified small-molecule reagent.
- Potent SIK inhibition (SIK1 = 6.56 nM, SIK2 = 1.77 nM, SIK3 = 20.5 nM).
- High reported purity (approximately 99.8% by HPLC).
- Molecular formula C30H37N7O2; molecular weight 527.66 g/mol.
- Available in multiple sizes and formats, including milligram quantities and a 10 mM solution in DMSO.
- For research use only; not for human or veterinary applications.
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Medchemexpress LLC Mocetinostat | 726169-73-9 | >98.0% | 200 MG
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Mocetinostat is a benzamide histone deacetylase (HDAC) inhibitor selective for class I/IV HDACs, used as a research compound in epigenetics and oncology studies. Typical potency: HDAC1 0.15 μM; HDAC2 0.29 μM; HDAC3 1.66 μM; HDAC11 0.59 μM. For research use only.
- Selective class I/IV HDAC inhibitor.
- Used in epigenetics and cancer research.
- Typical purity >98% (supplier dependent).
- Molecular formula C23H20N6O; molecular weight ≈396.4 g/mol.
- Supplied as a 200 mg research pack.
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eMolecules 5336-90-3 | Acridine-9-carboxylic acid | Synthonix - Stock | MFCD00009734 | 223.231 | C14H9NO2 | 95.000 | OC(=O)c1c2ccccc2nc2ccccc12 | 5g | 525906617
Acridine-9-carboxylic acid | Synthonix - Stock | 5336-90-3 | MFCD00009734 | 223.231 | C14H9NO2 | 95.000 | OC(=O)c1c2ccccc2nc2ccccc12 | 5g | 525906617
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Medchemexpress LLC Cytochrome c (bovine heart) | 9007-43-6 | MFCD00130890 | 95.0% | 12,327 Da | 200MG
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Cytochrome c (bovine heart) is a heme-containing mitochondrial protein provided as a lyophilized powder for research use. It functions in electron transport and is commonly used as a reagent or standard in biochemical assays of oxidative phosphorylation, electron-transfer reactions, and apoptosis research. The material is characterized by its protein sequence and heme prosthetic group and is supplied at ~95% purity.
- Heme-containing mitochondrial protein suitable for biochemical studies.
- Commonly used as a reagent or standard in electron transport and apoptosis assays.
- Provided as a lyophilized powder for convenient storage and handling.
- Purity approximately 95.0% as listed by the manufacturer.
- Available in multiple pack sizes, including a 200 mg pack.
- Identified by CAS number 9007-43-6 for reference and traceability.
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eMolecules 1255942-06-3 | DBCO-AMINE | AstaTech | MFCD22380759 | 276.339 | C18H16N2O | 95.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 1g | 602855722
DBCO-AMINE | AstaTech | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 95.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 1g | 602855722
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Sigma Aldrich Fine Chemicals Biosciences Ethyl lactate 98 fCC fG25KG
Ethyl lactate is a major volatile flavor compound identified in Chinese Luzhou-flavor type liquor.
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eMolecules 4965-36-0 | 7-Bromoquinoline | Apollo Scientific US - Building Blocks | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 1g | 482597547
7-Bromoquinoline | Apollo Scientific US - Building Blocks | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 1g | 482597547
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eMolecules 4965-36-0 | 7-Bromoquinoline | Ambeed | MFCD03695823 | 208.058 | C9H6BrN | 98.000 | Brc1ccc2cccnc2c1 | 5g | 490534630
7-Bromoquinoline | Ambeed | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 98.000 | Brc1ccc2cccnc2c1 | 5g | 490534630
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