Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Dabigatran etexilate mesylate 872728-81-9 10mg
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Dabigatran etexilate mesylate (CAS 872728-81-9) is an orally administered prodrug that upon conversion to dabigatran functions as a selective and reversible direct thrombin inhibitor In biochemical assays dabigatran exhibits high affinity for human thrombin (Ki 4 5 nM) and inhibits thrombin-induced platelet aggregation (IC50 10 nM) without affecting other platelet activators In vitro it induces concentration-dependent prolongation of coagulation parameters including aPTT PT and ECT in human plasma In vivo studies in rats and rhesus monkeys demonstrate dose-dependent anticoagulant activity following both intravenous and oral administration Dabigatran etexilate is utilized in research focused on coagulation disorders and anticoagulant mechanisms
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TARGETMOL CHEMICALS INC Epalrestat 200MG
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Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control. Purity 99.54%
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Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG
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Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and a potent antiviral drug primarily used in the treatment of human immunodeficiency virus (HIV) type 1 infection. It is effective against various strains of HIV-1, including those resistant to other NNRTI treatments. This product is intended for research use only.
- Targets HIV-1 and HIV-2
- Inhibits non-nucleoside reverse transcriptase
- Effective against resistant HIV-1 strains
- Suitable for research applications
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Medchemexpress LLC SAAP 148 (TFA) | 99.55% | 3267.06 (free base) | 5 MG
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SAAP 148 TFA is a potent antimicrobial and antibiofilm agent designed for research applications. This compound demonstrates inhibitory efficacy against antibiotic-resistant pathogens. Its mechanism of action targets both planktonic bacteria and established biofilms.
- Antimicrobial action: Effectively combats a range of antibiotic-resistant bacteria.
- Antibiofilm properties: Inhibits the formation and disrupts existing bacterial biofilms.
- High purity: Exhibited at 99.55% purity, ensuring reliable experimental results.
- Research grade: Suitable for various in vitro and in vivo studies (for research use only).
- Broad spectrum efficacy: Active against a variety of pathogens with LC50 values ranging from 0.8 to 12.8 μM.
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Medchemexpress LLC Nutlin-3a 200mg
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Nutlin-3a (Rebemadlin) an active enantiomer of Nutlin-3 is a potent murine double minute (MDM2) inhibitor (IC50 90 nM) Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein and induces cell autophagy and apoptosis Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas1]2]
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428186 ACRIDINE ORANGE 10-N 5MG
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Cambridge Isotope Laboratories 1 2 4 5 8-PentaCN (PCN-59) (unlabeled) 100 ug/mL in nonane 1 mL
1 2 4 5 8-PentaCN (PCN-59) (unlabeled) 100 ug/mL in nonane 1 mL
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Medchemexpress LLC 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate | 406205-74-1 | 98.6% | 453.36 g·mol⁻1 | C18H13F6NO4S | 50 MG
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BAY 59-3074 is a cannabinoid CB1/CB2 receptor partial agonist originally reported by Bayer. It has been characterized in vitro and in vivo for analgesic and antihyperalgesic effects and is used in research to probe cannabinoid receptor pharmacology.
- Selective CB1/CB2 receptor partial agonist (human CB1 Ki = 48.3 nM; human CB2 Ki = 45.5 nM).
- High purity: 98.6%.
- Chemical formula C18H13F6NO4S; molecular weight 453.36 g·mol⁻1.
- Solid, white to off-white physical form, suitable for laboratory handling.
- Documented in peer-reviewed literature and product datasheets for research use.
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Apexbio Technology LLC WAY-100635 162760-96-5 200mg
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WAY-100635 (CAS 162760-96-5) is a highly selective antagonist of the serotonin 5-HT1A receptor In vitro studies show that WAY-100635 displaces the 5-HT1A radioligand [3H]8-OH-DPAT from rat hippocampal membranes with a pIC50 of 8 87 and acts as a potent antagonist in functional assays without agonist or partial agonist activity In ex vivo guinea pig ileum assays it effectively blocks 5-carboxamidotryptamine-induced 5-HT1A responses (pA2 9 71 at 0 3 nM) In vivo WAY-100635 counteracts 8-OH-DPAT-induced behavioral and thermoregulatory effects in rodents at subcutaneous doses as low as 0 003 0 01 mg/kg It is widely utilized in neuropharmacological research and neuroimaging as a SPECT/PET ligand to investigate 5-HT1A receptor function in psychiatric and neurological disorders
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Cambridge Isotope Laboratories CGA 580 / 3L carbon steel cylinder packless brass angle ea
CGA 580 / 3L carbon steel cylinder packless brass angle ea
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431159 CYANINE5.5 AMINE 5MG
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Medchemexpress LLC 7-Deazaguanine | 7355-55-7 | 99.7% | 150.14 | 10 G
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7-Deazaguanine is described as a highly selective, well-tolerated, and brain-penetrant DYRK1A inhibitor. It holds promise for research related to cancers and Down's syndrome.
- Highly selective DYRK1A inhibitor.
- Well-tolerated.
- Brain-penetrant.
- Promising for research in cancers and Down's syndrome.
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Medchemexpress LLC Hydroquinidine | 1435-55-8 | 99.9% | 1 ML
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Potent ion channel blocker
- Exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells
- Prolongs the QT interval
- Possesses antiarrhythmic efficacy
- For research use only
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Cayman Chemical Propidium Iodide 100MG
A fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm
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Medchemexpress LLC MHY1485 | 326914-06-1 | 99.9% | 200 MG
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MHY1485 is a potent, cell-permeable mTOR activator that targets the ATP domain of mTOR. It inhibits autophagy by suppressing the fusion between autophagosomes and lysosomes.
- Inhibits GCDC-induced autophagic activity in HCC cells
- Increases LC3II/LC3I ratio in rat liver Ac2F cells
- Dose-dependently increases phosphorylation of mTOR at Ser2448 and upregulates 4E-BP1 phosphorylation in Ac2F cells
- Blocks autophagy signaling induced by follicle-stimulating hormone (FSH) in female ICR mice
- Increases p-mTOR and p-S6K1 expression levels in mice
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