Quinolines and derivatives
Medchemexpress LLC 2-Aminoquinoline | 580-22-3 | 144.18 | 5 G
2-Aminoquinoline (2-Quinolinamine) is a promising compound identified as a bioavailable nNOS inhibitor. While it exhibits low human nNOS inhibition and limited selectivity against human eNOS, it demonstrates antiviral activity against the vaccinia virus and shows potential for research in antineurodegenerative agents.
- Acts as a nNOS inhibitor
- Exhibits antiviral activity against vaccinia virus
- Potential for antineurodegenerative agent research
- Solid appearance
Medchemexpress LLC EGFR-IN-86 | 3055550-22-3 | 99.9% | 423.49 | 5 MG
EGFR-IN-86 is an epidermal growth factor receptor (EGFR) inhibitor, characterized by its high activity against glioblastoma with an IC50 of 1.5 nM. This compound has demonstrated the ability to induce apoptosis and arrest the U87 cell cycle in the G2/M phase, indicating its potential as an anti-glioma agent.
- Acts as an EGFR inhibitor with high potency.
- Exhibits significant activity against glioblastoma.
- Induces apoptosis in cells.
- Arrests the U87 cell cycle in the G2/M phase.
- Available in solid form, with a white to off-white appearance.
- Purity of 99.92% ensures high quality for research applications.
- Easily soluble in DMSO for in vitro studies.
- Can be prepared for in vivo experiments using specific solvent protocols to ensure reliable results.
Medchemexpress LLC 8-Bromoisoquinoline | 63927-22-0 | 99.51% | C9H6BrN | 5 G
8-Bromoisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science-related research. It is for research use only.
- Purity: 99.51%
- Molecular weight: 208.05
- Formula: C9H6BrN
- CAS No.: 63927-22-0
- Appearance: Solid, off-white to yellow color
Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 | C31H32N2O8 | 5 G
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine analog used as a nucleoside building block and intermediate for the synthesis of modified oligonucleotides. It is supplied as a light-yellow solid with defined purity and storage specifications suited for research and preparative oligonucleotide chemistry.
- DMT protected at the 5' hydroxyl for selective chain assembly.
- 2'-O-methyl modification supports increased nuclease resistance in oligonucleotides.
- High purity material suitable for synthesis and analytical workflows.
- Available in gram-scale pack sizes to accommodate different synthesis scales.
- Stable under recommended storage conditions to preserve quality over time.
Medchemexpress LLC Pomalidomide-5-C9-NH2 (hydrochloride) | 2925306-22-3 | 98.7% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Pomalidomide-5-C9-NH2 hydrochloride is a pomalidomide-derived ligand for the cereblon (CRBN) E3 ubiquitin ligase, supplied as the hydrochloride salt for research use. It is primarily used as a CRBN-recruiting moiety in the design and synthesis of PROTACs and other targeted protein degradation tools, and is provided in small milligram quantities with high reported purity.
- Ligand for cereblon (CRBN) E3 ubiquitin ligase.
- Designed for use as a CRBN-recruiting moiety in PROTAC synthesis.
- Provided as the hydrochloride salt for improved stability and handling.
- High reported purity (98.68%) suitable for research applications.
- Available in small milligram quantities for medicinal chemistry workflows.
Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 ML
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a protected 2'-O-methyluridine nucleoside used as a building block in oligonucleotide synthesis and nucleoside chemistry. It is supplied as a light yellow solid and as a 10 mM solution in DMSO for laboratory research applications.
- Protected 2'-O-methyl uridine analog for oligonucleotide synthesis.
- Available as a light yellow solid and as a 10 mM solution in DMSO.
- Purity 98.0% (data sheet).
- Molecular formula C31H32N2O8; molecular weight 560.59 g/mol.
- Supplied in multiple solid sizes for scale flexibility.
Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | 98.0% | 560.59 g/mol | C31H32N2O8 | 1 G
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine nucleoside analog with a 2'-O-methyl ribose modification, used as an intermediate in the chemical synthesis of modified oligonucleotides and nucleoside derivatives. Molecular formula C31H32N2O8; molecular weight 560.59 g/mol. Follow supplier storage recommendations for long-term stability.
- DMT-protected at the 5'-position for controlled deprotection.
- 2'-O-methyl modification enhances nuclease resistance.
- Designed for incorporation into synthetic oligonucleotides.
- High purity (98.0%) suitable for research applications.
- Stable as a powder under recommended storage conditions.
Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 g/mol | C31H32N2O8 | 10 G
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected 2'-O-methyl uridine nucleoside used as a building block and intermediate for solid-phase oligonucleotide synthesis and for research on modified RNA. It is supplied as a high-purity solid or as a DMSO solution to facilitate incorporation into synthesis workflows.
- DMT-protected 2'-O-methyl uridine suitable for oligonucleotide synthesis.
- High purity (98.03%) for reliable reactions.
- Available as powder and 10 mM solution in DMSO for flexibility.
- Long-term storage stability when kept at recommended temperatures.
- Datasheet, COA, and SDS available to support quality control.
Ambeed 2S 5R 5 6Amino9Hpurin9yl tet
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol, 4097-22-7, 98%
Ambeed 2S 5R 5 6Amino9Hpurin9yl tet
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol, 4097-22-7, 98%
Ambeed 2S 5R 5 6Amino9Hpurin9yl tet
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol, 4097-22-7, 98%
Ambeed 2S 5R 5 6Amino9Hpurin9yl tet
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol, 4097-22-7, 98%
Apexbio Technology LLC Amsacrine 51264-14-3 200mg
Amsacrine (CAS 51264-14-3) also known as m-AMSA is a small-molecule inhibitor of DNA topoisomerase II It is widely used as an antineoplastic agent in biomedical research particularly for investigating the treatment of lymphomas and acute leukemias Amsacrine exhibits cytotoxic effects across various cancer cell lines with reported IC50 values of 190 2 27 4 ng/ml 46 1 3 9 ng/ml and 22 6 3 1 ng/ml in HT1376 RT112 and RT4 bladder cancer cells and 11 8 2 0 ng/ml 5 0 0 4 ng/ml and 11 7 1 5 ng/ml in the 833K Susa and GH testicular cancer cell lines respectively Testicular cancer cell lines display greater sensitivity to Amsacrine-induced inhibition than bladder cancer cell lines This compound is valuable for studying DNA damage mechanisms and the cellular response to topoisomerase II inhibition