Tetrahydroisoquinolines
Medchemexpress LLC HY-N0049 5mg Medchemexpress, Nuciferine CAS:475-83-2 Purity:>98%
Medchemexpress, HY-N0049 5mg Nuciferine CAS:475-83-2 Nuciferine is an antagonist at 5-HT 2A ( IC 50 =478 nM), 5-HT 2C ( IC 50 =131 nM), and 5-HT 2B ( IC 50 =1 μM), an inverse agonist at 5-HT 7 ( IC 50 =150 nM), a partial agonist at D 2 ( EC 50 =64 nM), D 5 ( EC 50 =2.6 μM) and 5-HT 6 ( EC 50 =700 nM), an agonist at 5-HT 1A ( EC 50 =3.2 μM) and D 4 ( EC 50 =2 μM) receptor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 625375-83-9 | Medchem Express | Tariquidar (methanesulfonate hydrate) | 10mg | 446258845 | HY-10550A | MFCD25372040 | 892.99 | C40H52N4O15S2
Medchem Express | Tariquidar (methanesulfonate hydrate) | 10mg | 446258845 | HY-10550A | 625375-83-9 | MFCD25372040 | 892.990 | C40H52N4O15S2
Medchemexpress LLC 1(2H)-isoquinolinone, 5-hydroxy- | 5154-02-9 | MFCD00006900 | 99.1% | 161.16 g·mol⁻¹ | C9H7NO2 | 1 ML
1,5-Isoquinolinediol is a small-molecule poly(ADP-ribose) polymerase (PARP) inhibitor (CAS 5154-02-9) used in biochemical research. It exhibits in vitro potency with reported IC50 values of 0.18-0.37 μM and is employed to study PARP-mediated oxidative stress, including diabetes-induced NADPH oxidase-derived retinal damage.
- High purity suitable for research applications.
- Reported IC50 0.18-0.37 μM against PARP.
- Molecular formula C9H7NO2; molecular weight 161.16 g·mol⁻¹.
- Available as solid and as a 10 mM solution in DMSO.
- Used to study PARP-related oxidative stress and retinal models.
- Supplied with a certificate of analysis for batch-specific quality.
Medchemexpress LLC NBI-31772 | 374620-70-9 | 98.9% | 341.27 | 100 MG
NBI-31772 is a non-selective IGFBP inhibitor with a Ki of 47 nM. It exhibits neuroprotective effects, reducing infarct volume during cerebral ischemia. It can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes and increases the effect of IGF3 on zebrafish oocyte maturation.
- Stimulates the synthesis of IGF-1-dependent proteoglycans in human OA chondrocytes.
- Significantly stimulates the percentage of rabbit articular chondrocyte-associated proteoglycans.
- Dose-dependently induces the maturation of zebrafish oocytes.
- Reduces total infarct volume and cortical infarct volume in rats with middle cerebral artery occlusion (MCAO) model.
- Reduces cortical infarct size and brain swelling in rats with intraluminal suture MCAO model.
- Induces germinal vesicle rupture in zebrafish.
eMolecules 1263374-32-8 | 4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile | MFCD19215914 | 250mg
Ambeed | 111-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide | 1g | 490495476 | A113669 | 145100-50-1 | MFCD00191834 | 358.230 | C7H4F6N2O4S2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
eMolecules 41034-52-0 | 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid | Chem-Impex | MFCD01318704 | 177.203 | C10H11NO2 | 99.000 | OC(=O)C1NCCc2ccccc12 | 1g | 386895530
1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid | Chem-Impex | 41034-52-0 | MFCD01318704 | 177.203 | C10H11NO2 | 99.000 | OC(=O)C1NCCc2ccccc12 | 1g | 386895530
![eMolecules 3722-44-9 | 3-Hydroxy-7,8,9,10-tetrahydro-6h-benzo[c]chromen-6-one | Combi-Blocks | MFCD00488337 | 216.236 | C13H12O3 | 95.000 | Oc1ccc2c3CCCCc3c(=O)oc2c1 | 1g | 482935289](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502186036.JPG-250.jpg)
eMolecules 3722-44-9 | 3-Hydroxy-7,8,9,10-tetrahydro-6h-benzo[c]chromen-6-one | Combi-Blocks | MFCD00488337 | 216.236 | C13H12O3 | 95.000 | Oc1ccc2c3CCCCc3c(=O)oc2c1 | 1g | 482935289
3-Hydroxy-7,8,9,10-tetrahydro-6h-benzo[c]chromen-6-one | Combi-Blocks | 3722-44-9 | MFCD00488337 | 216.236 | C13H12O3 | 95.000 | Oc1ccc2c3CCCCc3c(=O)oc2c1 | 1g | 482935289
Medchemexpress LLC Olodanrigan | 1316755-16-4 | 98.9% | 100 MG
Olodanrigan (EMA401) is a highly selective, orally active, and peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. This compound is currently under development as a therapeutic agent for neuropathic pain. Its analgesic action is attributed to the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, which effectively inhibits both DRG neuron hyperexcitability and the sprouting of DRG neurons.
- Highly selective AT2 receptor antagonist
- Orally active and peripherally restricted
- A therapeutic agent candidate for neuropathic pain
- Inhibits p38 and p42/p44 MAPK activation
- Prevents DRG neuron hyperexcitability and sprouting
- Purity of 98.9%
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC NBI-31772 | 374620-70-9 | 98.9% | 341.27 | 10 MG
NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). It has neuroprotective effects, reducing infarct volume during cerebral ischemia. It can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes and increases the effect of IGF3 on zebrafish oocyte maturation.
- Reduces infarct volume during cerebral ischemia
- Restores or enhances proteoglycan synthesis in osteoarticular chondrocytes
- Increases the effect of IGF3 on zebrafish oocyte maturation
- Stimulates IGF-1-dependent proteoglycans in human OA chondrocytes
- Stimulates rabbit articular chondrocyte-associated proteoglycans
- Induces maturation of zebrafish oocytes
- Reduces total and cortical infarct volume in MCAO model rats
- Reduces cortical infarct size and brain swelling in intraluminal suture MCAO model rats
Medchemexpress LLC PD 102807 5mg | 23062-91-1 | 5MG
PD 102807 is a M4 muscarinic receptor antagonist with an IC50 of 90 7 nM PD 102807 inhibits M1 M2 M3 M5 muscarinic receptor with IC50s of 6558 7 3440 7 950 0 and 7411 7 nM respectively[1 Antidyskinetic effect
Medchemexpress LLC D-tetrahydropalmatine | 3520-14-7 | MFCD11046348 | 99.8% | 355.43 | C21H25NO4 | 10 MG
D-Tetrahydropalmatine is an isoquinoline alkaloid research reagent that acts as a dopamine receptor antagonist with preferential affinity for D1 receptors and reported inhibition of organic cation transporter 1 (OCT1). It is supplied as a solid for pharmacological and biochemical studies of dopamine signaling.
- CAS number: 3520-14-7.
- Molecular formula: C21H25NO4.
- Molecular weight: 355.43.
- Purity: 99.8%.
- Appearance: white to light yellow solid.
- Solubility: 50 mg/mL in DMSO (≈140.67 mM).
- Storage: powder at -20°C for up to 3 years; in solution at -80°C for extended storage.
- Intended use: for research only, not for diagnostic or therapeutic applications.
Medchemexpress LLC D-Tetrahydropalmatine | 3520-14-7 | 355.43 | 5 MG
D-Tetrahydropalmatine is an isoquinoline alkaloid found primarily in the genus Corydalis. It functions as a dopamine (DA) receptor antagonist with preferential affinity for D1 receptors, and also acts as a potent inhibitor of organic cation transporter 1 (OCT1).
- Dopamine D1 receptor antagonist
- Potent organic cation transporter 1 (OCT1) inhibitor
- Isoquinoline alkaloid
- Derived from plants
Medchemexpress LLC YS-201 | 108852-42-2 | 457.52 | 20 MG
YS-201 is a dihydropyridine-type calcium channel antagonist. It has potential applications in the treatment of angina pectoris and hypertension. In vivo, YS-201 (Diperdipine) has been shown to reduce systemic vascular resistance and improve stroke index and left ventricular ejection fraction. It has an absolute bioavailability of 18.7% after intravenous and oral doses, with biliary excretion accounting for about 0.1% of its total clearance.
- Dihydropyridine-type calcium channel antagonist
- Potential for angina pectoris and hypertension treatment
- Reduces systemic vascular resistance
- Improves stroke index and left ventricular ejection fraction
- Absolute bioavailability of 18.7% after intravenous and oral doses
- Biliary excretion accounts for approximately 0.1% of total clearance