Tetrapyrroles and derivatives
Cayman Chemical Methylcobalamin, Purity: ≥98%, CAS: 13422-55-4, 500 mg
An analog of vitamin B12 with diverse neurological activities; promotes neurite outgrowth and survival in primary CGN and DRG cells and activation of ERK1/2 and Akt from 0.1-100 µM; improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury at 1 mg/kg per day; decreases the number of atypical mitochondria in the sciatic nerve and reduces vincristine-induced mechanical allodynia and thermal hyperalgesia in a rat model of neuropathic pain; reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of ALS; enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer
Abcam UCPH-101, Selective EAAT1 inhibitor, 1MG
MW 422.5 Da, Purity >98%. Selective inhibitor of EAAT1 (IC₅₀ = 0.67 μM). Displays >400-fold selectivity over EAAT2 and EAAT3. Blood-brain barrier permeable analog UCPH-102 also available (ab146404).
The product is subject to the following: Abcam Restricted Use Statement
Abcam E x endin-4 (E x enatide), GLP-1 receptor agonist, 1MG
MW 4187 Da, Purity >95%. Exendin-4 (Exenatide), GLP-1 receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 505124, ALK5 inhibitor, 10MG
MW 335.4 Da, Purity >98%. Potent, reversible, competitive ALK5 inhibitor (IC₅₀ values are 47 and 129 nM for ALK5 and ALK4 respectively). Inhibits ALK7 but not ALK1, 2, 3, or 6. Shows antifibrotic effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam P5091, USP-7 inhibitor, 25MG
MW 348.2 Da, Purity >98%. Potent, selective and cell-permeable USP-7 inhibitor (EC₅₀ = 4.2 μM). Induces apoptosis in cancer cells in vitro. Antiangiogenic and antitumor agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ODQ, NO-sensitive guanylyl cyclase inhibitor, 50MG
MW 187.15 Da, Purity >99%. Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist, 5MG
MW 1084.2 Da, Purity >95%. (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168077 maleate, D4 agonist, 50MG
MW 450.49 g/mol, Purity >98%. Potent, selective D₄ dopamine receptor agonist. Displays >400-fold selectivity over D₂ and >300-fold selectivity over D₃ subtypes (Ki values are 11.9, 2540, and 1050 nM for D₄, D₃, and D₂ receptors, respectively). Reverses object recognition deficits.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Bisindolylmaleimide II, PKC inhibitor, 5MG
MW 438.5 Da, Purity >97%. Potent, selective ATP-competitive PKC inhibitor (IC₅₀ values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC₅₀ = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Verteporfin (Visudyne), Benzoporphyrin derivative, 25MG
MW 718.8 Da, Purity >96%. Benzoporphyrin derivative. Antiangiogenic agent. Produces ROS on stimulation with nonthermal red light in the presence of oxygen. Prevents corneal neovascularization and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist, 25MG
MW 283.41 Da, Purity >99%. Selective protease-activated receptor 2 (PAR2) antagonist (IC₅₀ = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pancuronium dibromide, Competitive nicotinic acetylcholine receptor antagonist, 250MG
MW 732.7 Da. Competitive nicotinic acetylcholine receptor (nAChR) antagonist. Displaces acetylcholine (ab120469) from nAChRs (IC₅₀ = 5.5 nM). Neuromuscular blocker and muscle relaxant.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Zinc Protoporphyrin-9, CAS: 15442-64-5, 25 mg
A competitive inhibitor of heme oxygenase that also inhibits soluble guanylyl cyclase and inactivates the NOS isoforms nNOS, iNOS, and eNOS (IC50s = 0.8, 4, and 5 μM, respectively); used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia
Abcam Cytochalasin D, actin polymerization inhibitor, 1MG
MW 507.6 Da, Purity >98%. Cytochalasin D, actin polymerization inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam JC-1, Mitochondrial membrane potential dye, 5MG
MW 652.2 Da, Purity >95%. Mitochondrial membrane-potential dye. Exhibits potential-dependent accumulation in mitochondria. Fluorescence emission shift from green (~529 nm) to red (~590 nm). Depolarization is indicated by a decrease in the red/green fluorescence intensity ratio.
The product is subject to the following: Abcam Restricted Use Statement