Tetrapyrroles and derivatives
Abcam SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist, 50MG
MW 292.33 Da, Purity >99%. Potent and selective 5-HT2B and 5-HT2C serotonin receptor antagonist (pKi values are 7.92 (5-HT2C), 5.78 (5-HT2A), 7.65 (5-HT2B), 1A), 1D), 1E) and 1F). Centrally active following oral administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (R)-CPP (mM/ml), NMDA antagonist, 10MM_ML
MW 252.2 Da. Highly potent, competitive NMDA antagonist; more active enantiomer of (RS)-CPP (ab120160). (Ki values are 0.04, 0.3, 0.6 and 2.0 μM at NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Verteporfin (Visudyne), Benzoporphyrin derivative, 25MG
MW 718.8 Da, Purity >96%. Benzoporphyrin derivative. Antiangiogenic agent. Produces ROS on stimulation with nonthermal red light in the presence of oxygen. Prevents corneal neovascularization and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam (±)-Miconazole nitrate, Imidazole antifungal agent, 5G
MW 479.1 Da, Purity >99%. Imidazole antifungal agent. Inhibits fungal membrane ergosterol biosynthesis. Increases reactive oxygen species production.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TC-2403 o x alate, alpha4beta2 nAChR selective agonist, 10MG
MW 252.27 g/mol, Purity >99%. High affinity α4β2 nAChR selective agonist (Ki = 26 nM). Selective for CNS nAChR over muscle, ganglionic or enteric ACh receptors (EC₅₀ = 732 nM in rat thalamic synaptosomes).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Bisindolylmaleimide II, PKC inhibitor, 5MG
MW 438.5 Da, Purity >97%. Potent, selective ATP-competitive PKC inhibitor (IC₅₀ values are 0.01, 0.75 and 2 μM for PKC, phosphorylase kinase and PKA respectively). Potent noncompetitive nAChR antagonist (IC₅₀ = 0.03 μM, catecholamine secretion in nicotine-stimulated PC-12 cells). Shows more potent antinicotinic effects than Bisindolylmaleimide IV (ab144208) and V (ab144205). Induces apoptosis and shows antiproliferative effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam P5091, USP-7 inhibitor, 25MG
MW 348.2 Da, Purity >98%. Potent, selective and cell-permeable USP-7 inhibitor (EC₅₀ = 4.2 μM). Induces apoptosis in cancer cells in vitro. Antiangiogenic and antitumor agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Prodigiosin, apoptotic agent, 250UG
MW 323.4 Da, Purity >95%. Potent apoptotic agent. Antibiotic agent. Induces caspase-dependent apoptosis. Inhibits mTORC1 and mTORC2. Reactivates p53. Inhibits iNOS expression. Shows anti-ischemic and antimalarial effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam Edaravone (MCI-186), antio x idant, 50MG
MW 174.2 Da, Purity >99%. Free radical scavenger and potent antioxidant. Inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Zaprinast, cGMP phosphodiesterase inhibitor, 50MG
MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC₅₀ values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Nafadotride, D3 antagonist, 50MG
MW 365.5 Da, Purity >99%. Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-3CT, MMP-2 and MMP-9 inhibitor, 5MG
MW 306.4 Da, Purity >98%. Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Frontier Specialty Chemicals 250MG MESO-TETRA(PENTAFLUOROPH
meso-Tetra(pentafluorophenyl)porphine chlorin free; CAS: 25440-14-6; 250mg
Frontier Specialty Chemicals 250MG MESO-TETRA(4-CARBOXYPHEN
meso-Tetra(4-carboxyphenyl)porphine; CAS: 14609-54-2; 250mg
Frontier Specialty Chemicals 5G MESO-TETRAPHENYLPORPHINE (C
meso-Tetraphenylporphine (chlorin free); CAS: 917-23-7; 5g