Tetrapyrroles and derivatives
Sigma Aldrich Fine Chemicals Biosciences Hemin | 16009-13-5 | MFCD00010726 | 1g
Hemin | Purity: 90% | Mol Wt: 651.94 | 16009-13-5 | MFCD00010726 | 1g
Abcam Necrostatin-1, necroptosis inhibitor, 5MG
MW 259.33 Da, Purity >99%. Potent, specific necroptosis inhibitor (EC₅₀ = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC₅₀ = 182 nM). Caspase independent, programmed necrosis pathway.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Methylcobalamin (standard) | 13422-55-4 | 96.8% | 100 MG
Methylcobalamin (Standard) is an analytical standard, also known as Mecobalamin (Standard) or CH3-B12 (Standard). It serves as a reference standard for assay and is intended for research and analytical applications. It is commonly utilized in qualitative, quantitative, and methodological research experiments.
- Used as a reference standard for assay
- Suitable for qualitative, quantitative, and methodological research experiments
- Compatible with techniques such as HPLC, GC, and MS
- Intended for research and analytical applications only
Apexbio Technology LLC Chlorin e6(Synonyms: Ce6, Chlorophyllin e6, Chlorophyll derivative e6, Chlorin-e6, Chlorin e-6), 100mg, CAS: 19660-77-6.
Chlorin e6 (Ce6 CAS 19660-77-6) is a second-generation photosensitizer utilized in photodynamic therapy (PDT) research with demonstrated anticancer activity when activated by laser irradiation Upon irradiation Ce6 generates reactive oxygen species mediating cytotoxic effects and cellular apoptosis In mouse models intravenous administration of Ce6 (2 5 10 mg/kg) combined with irradiation (50 200 J/cm ) resulted in complete elimination of implanted fibrosarcomas In clinical trials for bronchogenic superficial squamous cell carcinoma Ce6-based PDT (40 mg/m 100 J/cm ) produced complete response rates up to 82 9% underscoring its utility for cancer therapy studies
Medchemexpress LLC Methylcobalamin | 13422-55-4 | 99.0% | 1 ML
Methylcobalamin, a cobalamin and form of vitamin B12, is characterized by a methyl group replacing the cyanide found in cyanocobalamin. This compound features an octahedral cobalt(III) centre and is known for its rare metal-alkyl bonds. Physiologically, it functions as vitamin B12, addressing deficiencies such as pernicious anemia, and is also applied in treating peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis.
- Form of vitamin B12 (cobalamin)
- Contains a methyl group instead of cyanide
- Features an octahedral cobalt(III) centre and metal-alkyl bonds
- Equivalent to vitamin B12 for treating deficiencies (e.g., pernicious anemia)
- Used in peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis treatment
Medchemexpress LLC Protoporphyrin IX | 553-12-8 | MFCD00078028 | ≥98.0% | 100 MG
Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. It also functions as a photosensitizer, undergoing photobleaching through direct degradation by light irradiation. It accumulates following 5-aminolevulinic acid (5-ALA) administration in rat tumor cells. When activated by red fluorescence at a peak wavelength of 405 nm, Protoporphyrin IX selectively improves basal cell carcinoma. It shows promise as a sonodynamic and photodynamic agent for various cancers, including bladder cancer and nodular basal cell carcinoma.
- Acts as a radiation sensitizer enhancing ROS generation.
- Induces DNA damage.
- Acts as a photo sensitizer.
- Promising for research of sonodynamic and photodynamic agents for a wide range of cancers.
Cayman Chemical N-methyl ProtoporphyrIn IX 1mg
A transition state analog that potently inhibits protoporphyrin IX ferrochelatase (Ki = 10 nM), blocking the terminal step of the heme biosynthetic pathway
Abcam Genipin, Cell-permeable uncoupling protein 2 inhibitor, 25MG
MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SEN 12333, alpha7 nicotinic acetylcholine receptor (nAChR) agonist, 10MG
MW 339.4 Da, Purity >98%. Potent, selective α7 nicotinic acetylcholine receptor (nAChR) agonist. High affinity for rat α7 receptors (Ki = 260 nM). Full agonist in functional Ca²+ flux studies (EC₅₀ = 1.6 μM). Active in vivo and in vitro. Excellent brain penetration. Orally bioavailable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Verteporfin (Visudyne), Benzoporphyrin derivative, 5MG
MW 718.8 Da, Purity >96%. Benzoporphyrin derivative. Antiangiogenic agent. Produces ROS on stimulation with nonthermal red light in the presence of oxygen. Prevents corneal neovascularization and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Bilirubin conjugate disodium | 68683-34-1 | MFCD00044931 | 95.0% | C37H44N6Na2O10S2 | 10MG
Bilirubin conjugate disodium is a water-soluble, ditaurate derivative of bilirubin used as a research reagent and drug-metabolite reference for studies of heme metabolism and assay development. The material is supplied as the disodium salt (C37H44N6Na2O10S2) and is accompanied by analytical documentation for laboratory use.
- High purity (95.0%).
- Water-soluble disodium salt for aqueous assays.
- Suitable as a reference standard in bilirubin and drug-metabolite studies.
- Provided with certificate of analysis and safety data sheet.
- Available in small quantity packages for research applications.
Sigma Aldrich Fine Chemicals Biosciences Methylcobalamin United Sta50MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Medchemexpress LLC Pyraclonil | 158353-15-2 | MFCD11112213 | 97.0% | 314.77 g/mol | C15H15ClN6 | 10 MG
Pyraclonil is a proporphyrinogen oxidase (PPO) inhibitor and herbicide agent supplied as a research-grade solid. The compound has molecular formula C15H15ClN6, molecular weight 314.77 g/mol, and supplier-reported purity of approximately 97%. Intended for laboratory research use; consult the safety data sheet (SDS) for handling and storage instructions.
- PPO inhibitor suitable for herbicide and biochemical research.
- High purity (~97%) appropriate for analytical and biological assays.
- Supplied in a small research pack for method development and screening.
- Defined molecular weight and formula support accurate dosing.
- Refer to the SDS for storage, handling, and safety information.
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | 917-23-7 | MFCD00011680 | 5G
5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | Purity: 97% | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 5G