Tetrapyrroles and derivatives
Medchemexpress LLC Methylcobalamin | 13422-55-4 | 99.0% | 1 ML
Methylcobalamin, a cobalamin and form of vitamin B12, is characterized by a methyl group replacing the cyanide found in cyanocobalamin. This compound features an octahedral cobalt(III) centre and is known for its rare metal-alkyl bonds. Physiologically, it functions as vitamin B12, addressing deficiencies such as pernicious anemia, and is also applied in treating peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis.
- Form of vitamin B12 (cobalamin)
- Contains a methyl group instead of cyanide
- Features an octahedral cobalt(III) centre and metal-alkyl bonds
- Equivalent to vitamin B12 for treating deficiencies (e.g., pernicious anemia)
- Used in peripheral neuropathy, diabetic neuropathy, and amyotrophic lateral sclerosis treatment
Abcam Monosodium urate, Pro-inflammatory agent, 2MG
MW 190.09 Da. NLRP3/NALP3 inflammasome activator. Stimulates caspase-1 activating NLRP3/NALP3 inflammasome, results in active IL-1β and IL-18 production. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Cyanocobalamin (Vitamin B12 Standard) | 68-19-9 | 99.95% | 100 MG
Vitamin B12 (Standard) is the analytical standard of Vitamin B12. This product is intended for research and analytical applications. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood.
- Analytical standard for research and analytical applications
- Supports normal functioning of the brain and nervous system
- Essential for the formation of blood
- Suitable as a reference standard in HPLC, GC, and MS experiments
Medchemexpress LLC Vitamin B12 | 68-19-9 | 99.99% | 1 ML
Vitamin B12 (Cyanocobalamin) is a crucial vitamin involved in the metabolism of every cell, particularly affecting DNA synthesis, fatty acid synthesis, and energy production. It plays a key role in brain and nervous system function, and blood formation, offering protection against oxidative stress and benefiting inflammatory diseases.
- Passes through the blood-brain barrier
- Involved in cell metabolism
- Supports DNA synthesis and regulation
- Aids in fatty acid synthesis and energy production
- Beneficial for inflammatory diseases
- Provides protection in oxidative-stress-associated pathologies
Abcam L-threo-PDMP, 10MG
MW 427.03 g/mol, Purity >98%. Enantiomer of D-threo-PDMP (Asc 4052). Activates glycosyltransferases for ganglioside biosynthesis. Antineurodegenerative properties. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Paprotrain, MKLP-2 inhibitor, 1MG
MW 245.28 Da, Purity >98%. Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC₅₀ values are 1.35 and 0.83 μM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Chlorophyll a from spinach10MG
Chlorophyll a is an important green or blue color pigment in most organisms which is implicated in oxygenicnbspphotosynthesis. It functions as an antenna pigment in photosystems I and II.
Sigma Aldrich Fine Chemicals Biosciences Hemin | 16009-13-5 | MFCD00010726 | 1g
Hemin | Purity: 90% | Mol Wt: 651.94 | 16009-13-5 | MFCD00010726 | 1g
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetrakis(4-hydroxyphenyl)-21H,23H-porphine Dye content 95 % | 51094-17-8 | MFCD00191501 | 1G
5,10,15,20-Tetrakis(4-hydroxyphenyl)-21H,23H-porphine Dye content 95 % | Mol Wt: 678.73 | 51094-17-8 | MFCD00191501 | 1G
Sigma Aldrich Fine Chemicals Biosciences Coenzyme B12 >=97.0% | 13870-90-1 | MFCD00135609 | 1G
Coenzyme B12 >=97.0% | Purity: >=97.0% | Mol Wt: 1579.58 | 13870-90-1 | MFCD00135609 | 1G
Abcam AR 231453, GPR119 agonist, 5MG
MW 505.5 Da, Purity >99%. Potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC₅₀ = 0.68 nM). Enhances glucose-induced insulin release. Antidiabetic activity. Orally active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AR 231453, GPR119 agonist, 25MG
MW 505.5 Da, Purity >99%. Potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC₅₀ = 0.68 nM). Enhances glucose-induced insulin release. Antidiabetic activity. Orally active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TPEN, Metal ion chelator, 100MG
MW 424.5 Da, Purity >99%. Metal ion chelator. Decreases intracellular zinc levels. Induces apoptosis. Causes defects in oocyte maturation. Modulates hippocampal neurogenesis following seizure. Cell permeable. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Protoporphyrin IX (disodium) | 50865-01-5 | 96.5% | 25 MG
Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway. It acts as a radiation sensitizer, enhancing ROS generation even in hypoxic conditions and inducing DNA damage. It also functions as a photosensitizer, undergoing photobleaching through direct degradation by light irradiation. This product is promising for research of sonodynamic and photodynamic agents for various cancers, including bladder cancer and nodular basal cell carcinoma.
- Final intermediate in the heme biosynthetic pathway
- Acts as a radiation sensitizer
- Enhances ROS generation and induces DNA damage
- Functions as a photosensitizer
- Undergoes photobleaching by light irradiation
- Accumulates in tumor cells after 5-aminolevulinic acid administration
- Causes selective improvement of basal cell carcinoma
- Promising for research into sonodynamic and photodynamic agents for various cancers