Tetrapyrroles and derivatives
Abcam Zaprinast, cGMP phosphodiesterase inhibitor, 50MG
MW 271.28 g/mol, Purity >98%. Specific cGMP phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15 (PDE6), 0.76 (PDE5), 12 (PDE11) and 29 μM (PDE9)). Reputed GPR35 agonist (EC₅₀ values are 16 and 840 nM at rat and human GPR35 receptors, respectively). Important mediator for a variety of cellular processes including vasodilation.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB-277011-A dihydrochloride, D3 antagonist, 25MG
MW 511.5 Da, Purity >98%. Potent, highly selective D3 receptor antagonist (pKi = 7.95 at hD3 receptors). Exhibits over 100-fold selectivity over D2 receptors. Blood-brain barrier (BBB) permeable. Diminishes nicotine, cocaine and alcohol self-administration. Interferes with mechanisms of drug-taking and reinstatement of drug-taking behaviours.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168568 dihydrochloride, D4 antagonist, 10MG
MW 422.4 g/mol, Purity >99%. Potent and selective D₄ antagonist (Ki = 8.8 nM at D₄, and 1842 nM at D₂). Inhibits amphetamine stimulated locomotor activity in vivo; orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rotigotine hydrochloride, Dopamine receptor agonist, 50MG
MW 351.93 g/mol, Purity >99%. Dopamine receptor agonist. High affinity for D₁, D₂ and D₃ receptors (Ki values are 83, 13 and 0.71 nM, respectively). Shows significant affinity at α₂B and 5-HT₁A receptors (Ki values are 27 and 30 nM, respectively). Exhibits anti-Parkinsonian and antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168077 maleate, D4 agonist, 50MG
MW 450.49 g/mol, Purity >98%. Potent, selective D₄ dopamine receptor agonist. Displays >400-fold selectivity over D₂ and >300-fold selectivity over D₃ subtypes (Ki values are 11.9, 2540, and 1050 nM for D₄, D₃, and D₂ receptors, respectively). Reverses object recognition deficits.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PNU 282987, alpha7 nAChR agonist, 50MG
MW 301.2 Da, Purity >99%. Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT₃ receptors (IC₅₀ = 4541 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist, 10MG
MW 292.33 Da, Purity >99%. Potent and selective 5-HT2B and 5-HT2C serotonin receptor antagonist (pKi values are 7.92 (5-HT2C), 5.78 (5-HT2A), 7.65 (5-HT2B), 1A), 1D), 1E) and 1F). Centrally active following oral administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GR 127935 hydrochloride, 5-HT1B/1D receptor antagonist, 10MG
MW 534.06 g/mol, Purity >97%. Potent and selective 5-HT₁B/₁D receptor antagonist (pKi = 8.5 for both 5-HT₁D in rat and 5-HT₁D in guinea pig). 100-fold selectivity over 5-HT₁A, 5-HT₁E, and 5-HT₂C. Displays centrally mediated effects upon systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 216763, GSK3 inhibitor, 10MG
MW 371.2 Da, Purity >98%. Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
The product is subject to the following: Abcam Restricted Use Statement
Abcam (R,S)-CPP, NMDA antagonist, 50MG
MW 252.2 Da. Potent, competitive NMDA antagonist. See separate isomer (ab120159). Also available in simple stock solutions (ab146720) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | 917-23-7 | MFCD00011680 | 25G
5,10,15,20-Tetraphenyl-21H,23H-porphine 97% | Purity: 97% | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 25G
Sigma Aldrich Fine Chemicals Biosciences meso-Tetraphenylporphyrin BioReagent, suitable for fluorescence, >=99.0% (HPLC) | 917-23-7 | MFCD00011680 | 250MG
meso-Tetraphenylporphyrin BioReagent, suitable for fluorescence, >=99.0% (HPLC) | Purity: >=99.0% (HPLC) | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 250MG
Sigma Aldrich Fine Chemicals Biosciences 5,10,15,20-Tetraphenyl-21H,23H-porphine >=99% | 917-23-7 | MFCD00011680 | 1G
5,10,15,20-Tetraphenyl-21H,23H-porphine >=99% | Purity: >=99% | Mol Wt: 614.74 | 917-23-7 | MFCD00011680 | 1G
Sigma Aldrich Fine Chemicals Biosciences Cytochrome c from bovine heart | 9007-43-6 | MFCD00130890 | 1g
Cytochrome c from bovine heart | Purity: ≥95% | Mol Wt: 12327 Da | 9007-43-6 | MFCD00130890 | 1g