Tetrapyrroles and derivatives
Abcam (±)-Miconazole nitrate, Imidazole antifungal agent, 1G
MW 479.1 Da, Purity >99%. Imidazole antifungal agent. Inhibits fungal membrane ergosterol biosynthesis. Increases reactive oxygen species production.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist, 50MG
MW 628.6 Da, Purity >99%. H1/H2 receptor agonist (Ki = 1.2 µM). More potent than histamine (ab120734). Activates IP3/Ca2+ signaling and induces proliferation of small cholangiocytes. Active *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist, 10MG
MW 628.6 Da, Purity >99%. H1/H2 receptor agonist (Ki = 1.2 µM). More potent than histamine (ab120734). Activates IP3/Ca2+ signaling and induces proliferation of small cholangiocytes. Active *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ciproxifan maleate, prototypic H3 inverse agonist / antagonist.
Ciproxifan maleate, prototypic H3 inverse agonist / antagonist.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Nafadotride, D3 antagonist, 50MG
MW 365.5 Da, Purity >99%. Potent, selective D3 antagonist (Ki values are 0.52 nM (D3), 269 nM (D4) and 5 nM (D2)).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Edaravone (MCI-186), antio x idant, 50MG
MW 174.2 Da, Purity >99%. Free radical scavenger and potent antioxidant. Inhibits production of reactive oxygen species, apoptosis and the lipoxygenase system.
The product is subject to the following: Abcam Restricted Use Statement
Abcam DPDPE, delta opioid receptor agonist, 5MG
MW 645.79 g/mol, Purity >95%. Potent and selective δ opioid receptor agonist (Ki values are 14, >1000 and >1000 nM for opioid receptor subtypes δ, κ and μ, respectively). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-745870 trihydrochloride, brain penetrant D4 antagonist, 10MG
MW 436.21 g/mol, Purity >99%. Highly potent and selective D₄ antagonist (Ki values are 0.43, 2300 and 960 nM at D₄, D₃ and D₂, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 216641 hydrochloride, h5-HT1B antagonist, 10MG
MW 523.03 g/mol, Purity >98%. Selective h5-HT₁B receptor antagonist. 25-fold selectivity over h5-HT₁D. Little or no affinity for a range of other receptor subtypes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PD 168568 dihydrochloride, D4 antagonist, 50MG
MW 422.4 g/mol, Purity >99%. Potent and selective D₄ antagonist (Ki = 8.8 nM at D₄, and 1842 nM at D₂). Inhibits amphetamine stimulated locomotor activity in vivo; orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GBR 12909 dihydrochloride, Dopamine transport inhibitor, 10MG
MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC₅₀ = 2.32 μM in rat hippocampal slices; IC₅₀ = 6-35 μM in whole cell patch clamp recordings).
The product is subject to the following: Abcam Restricted Use Statement
Abcam (S)-(-)-Raclopride, D2 receptor antagonist, 50MG
MW 347.24 g/mol, Purity >97%. High affinity (Kd = 1.2 nM) and high selectivity for D₂ receptors in vitro and in vivo (IC₅₀ = 32 nM). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB 206553 hydrochloride, 5-HT2B and 5-HT2C receptor antagonist, 50MG
MW 292.33 Da, Purity >99%. Potent and selective 5-HT2B and 5-HT2C serotonin receptor antagonist (pKi values are 7.92 (5-HT2C), 5.78 (5-HT2A), 7.65 (5-HT2B), 1A), 1D), 1E) and 1F). Centrally active following oral administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PNU 282987, alpha7 nAChR agonist, 10MG
MW 301.2 Da, Purity >99%. Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT₃ receptors (IC₅₀ = 4541 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-cis-Diltiazem, cyclic nucleotide-gated channel blocker, 5MG
MW 451 Da, Purity >97%. Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
The product is subject to the following: Abcam Restricted Use Statement