Thienothiazines
Apexbio Technology LLC Lornoxicam 70374-39-9 10mM (in 1mL DMSO)
Lornoxicam (CAS 70374-39-9) is an oxicam-class nonsteroidal anti-inflammatory drug (NSAID) that exerts its pharmacological effects primarily by potent inhibition of cyclooxygenase isoforms COX-1 and COX-2 with in vitro IC50 values of 5 nM and 8 nM respectively Studies in intact human cells and whole blood confirm its strong suppressive activity against both COX isoenzymes Additionally lornoxicam displays dose-dependent inhibition of nitric oxide formation (IC50 65 M) and reduction of IL-6 production in vitro Due to its robust COX inhibition and favorable pharmacokinetic profile lornoxicam is widely utilized as a research tool in studies investigating inflammation pain pathways and COX-mediated prostaglandin synthesis
Selleck Chemical LLC Lornoxicam S2047-10mg
Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor used as an anti-inflammatory drug to treat pain osteoarthritis and rheumatoid arthritis
Selleck Chemical LLC Lornoxicam S2047-50mg
Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor used as an anti-inflammatory drug to treat pain osteoarthritis and rheumatoid arthritis
TARGETMOL CHEMICALS INC BRINZOLAMIDE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. purity: 100%
Medchemexpress LLC Lornoxicam impurity 16 | 70374-37-7 | 25mg
Lornoxicam impurity 16 is an impurity of Lornoxicam (HY-B0367)
Selleck Chemical LLC Brinzolamide S3178-1g
Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3 19 nM
Cayman Chemical BrInzolamIde 25mg
A potent carbonic anhydrase inhibitor (IC50s = 3.19 and 45.3 nM for CAII and CAIV, respectively); selective for CAII and CAIV over CAI (IC50 = ~1,365 nM); reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice at 30 mg/kg; topical administration reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension at 0.25, 0.5, and 1 mg/eye; reduces IOP in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension
Cayman Chemical BRINZOLAMIDE 50MG
A potent carbonic anhydrase inhibitor (IC50s = 3.19 and 45.3 nM for CAII and CAIV, respectively); selective for CAII and CAIV over CAI (IC50 = ~1,365 nM); reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice at 30 mg/kg; topical administration reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension at 0.25, 0.5, and 1 mg/eye; reduces IOP in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension
Apexbio Technology LLC Brinzolamide 138890-62-7 50mg
Brinzolamide (CAS 138890-62-7) is a potent and selective inhibitor of carbonic anhydrase II (CA II) with an IC50 of 3 19 nM and a Ki of 0 13 nM in vitro By inhibiting CA II brinzolamide disrupts the reversible hydration of carbon dioxide thereby reducing aqueous humor production and lowering intraocular pressure Demonstrated to have higher affinity and inhibitory efficacy for CA II compared to CA I and CA IV brinzolamide has been shown to significantly decrease intraocular pressure in animal models Additionally it is utilized in research settings to assess cerebral blood flow reserve as CA inhibition modulates tissue CO2 levels and consequent vasodilation
- 1
- 2