Guanidines
Apexbio Technology LLC Metformin HCl 1115-70-4 10g
Metformin hydrochloride (Metformin HCl CAS 1115-70-4) is a widely studied small molecule employed in biomedical research primarily for investigating glucose metabolism and type 2 diabetes mechanisms It acts through selective inhibition of hepatic gluconeogenesis without directly increasing insulin secretion The molecular targets include activation of AMP-activated protein kinase (AMPK) subsequently suppressing acetyl-CoA carboxylase (ACC) activity attenuating lipid biosynthesis and promoting fatty acid oxidation Additionally metformin inhibits mitochondrial glycerophosphate dehydrogenase (mGPD) changing cellular redox status and reducing lactate-driven gluconeogenesis pathways Key research applications of Metformin HCl include studies on glucose homeostasis metabolic disorders and AMPK signaling cascades
Medchemexpress LLC Biguanide | 56-03-1 | 98.1% | 100 MG
Biguanide is an orally active antihyperglycemic research reagent used to investigate mitochondrial metabolism and insulin signaling. It inhibits mitochondrial ATP production and activates the LKB1-AMPK pathway, altering cellular energy homeostasis.
- Used to study mitochondrial metabolism and AMPK signaling.
- Inhibits mitochondrial ATP production.
- Enhances insulin-receptor activation and downstream signaling.
- Typical purity 98.1% for research use.
- Provided as a solid suitable for in vitro and in vivo model studies.
Medchemexpress LLC Biguanide | 56-03-1 | 98.1% | 25 MG
Biguanide is a small-molecule antihyperglycemic research reagent (CAS 56-03-1) that inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and enhances insulin-receptor signaling. It is intended for research use only.
- Antihyperglycemic activity; modulates mitochondrial metabolism.
- Activates LKB1-AMPK signaling and enhances insulin receptor signaling.
- Molecular formula C2H7N5; molecular weight 101.11 g/mol.
- Supplied as a solid in small pack sizes for research applications.
- For research use only; not for human therapeutic use.
Medchemexpress LLC PSB-1115 | 152529-79-8 | 99.0% | 350.35 | C14H14N4O5S | 5 MG
PSB-1115 is a selective A2B adenosine receptor antagonist supplied for research use to investigate A2B-mediated signaling and physiological responses. It has documented activity in TNBS-induced contraction models and is provided in solid and solution formats for experimental applications.
- Selective A2B adenosine receptor antagonist.
- Research-use compound for A2B receptor studies.
- Purity 99.0%.
- Molecular formula C14H14N4O5S; molecular weight 350.35.
- CAS number 152529-79-8.
- Available in solid 5 mg and solution 10 mM 1 mL in DMSO.
- Store at -20°C; protect from light. In solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Metformin impurity 1 | 1674-62-0 | ≥97.0% | 151.60 | 500 MG
Metformin impurity 1 (Standard) is the analytical standard of Metformin impurity 1. This product is intended for research and analytical applications. The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
- Intended for research and analytical applications.
- Analytical standard, suitable for reference standard supplied assay.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Selleck Chemical LLC 1-Phenylbiguanide S2578-25mg
1-Phenylbiguanide (Phenylbiguanide PBG N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3 0 M
TARGETMOL CHEMICALS INC Metformin 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research. Purity 99.77%
Sigma Aldrich Fine Chemicals Biosciences Metformin hydrochloride | 1115-70-4 | MFCD00012582 | 200 mg
Metformin hydrochloride | Mol Wt: 165.62 | 1115-70-4 | MFCD00012582 | 200 mg
Medchemexpress LLC Metformin (hydrochloride) | 1115-70-4 | 100.0% | 165.62 | 100 MG
Metformin hydrochloride is a compound that inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful in type 2 diabetes research. It also lowers glucose by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons and reduces liver oxidative stress, inflammation, and apoptosis. Additionally, it regulates autophagy and inhibits renal cell carcinoma growth by activating AMPK and inhibiting the mTOR pathway.
- Inhibits mitochondrial respiratory chain
- Activates AMPK and enhances insulin sensitivity
- Used for type 2 diabetes research
- Lowers glucose by inhibiting Rap1
- Reduces liver oxidative stress, inflammation, and apoptosis
- Regulates autophagy by activating AMPK
- Inhibits mTOR signaling pathway
- Induces tumor cell autophagy
- Inhibits renal cell carcinoma growth in vitro and in vivo
Medchemexpress LLC Metformin hydrochloride (standard) | 1115-70-4 | 99.97% | 165.62 | 5 MG
Metformin hydrochloride (Standard) is an analytical standard for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful for type 2 diabetes studies. It also inhibits liver oxidative stress and inflammation, and regulates autophagy to inhibit renal cell carcinoma growth.
- Analytical standard for research and analytical applications.
- Inhibits mitochondrial respiratory chain in the liver.
- Activates AMPK and enhances insulin sensitivity.
- Used in type 2 diabetes research.
- Inhibits liver oxidative stress and inflammation.
- Regulates autophagy-related proteins.
- Inhibits mTOR signaling pathway.
- Induces tumor cell autophagy and inhibits renal cell carcinoma growth.
- Suitable for HPLC, GC, and MS research.
Medchemexpress LLC Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1) | 1115-70-4 | 99.8% | 165.62 | 50 MG
Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1) | 1115-70-4 | 99.8% | 165.62 | 50 MG
Apexbio Technology LLC Metformin 657-24-9 50mg
Metformin (CAS 657-24-9) is a biguanide compound widely employed as an antihyperglycemic agent in type II diabetes research Its primary mechanism involves enhancing insulin sensitivity in peripheral tissues and reducing hepatic gluconeogenesis leading to lower circulating glucose levels without directly inducing hypoglycemia Metformin is also associated with decreased fasting plasma insulin concentrations and modest weight reduction These properties make it a valuable small molecule for investigating metabolic regulation insulin resistance and therapeutic strategies for obesity-associated metabolic disorders in preclinical and clinical studies
Medchemexpress LLC Biguanide | 56-03-1 | 98.1% | 10 MG
Biguanide (CAS 56-03-1) is a small-molecule biguanide base used as a research reagent. It is reported to inhibit mitochondrial ATP production, activate the LKB1-AMPK signaling pathway, and modulate insulin-receptor signaling; it is commonly used in metabolic and diabetes-related studies.
- Small-molecule biguanide reagent for research use
- CAS number 56-03-1
- Molecular formula C2H7N5; molecular weight 101.11 g/mol
- Reported to inhibit mitochondrial ATP production and activate AMPK signaling
- Used in metabolic, insulin signaling, and mitochondrial studies
- Available in a 10 MG vial; verify pack sizes with supplier