Nitrogen mustard compounds
Medchemexpress LLC Camonsertib | 2417489-10-0 | 99.99% | 410.47 | 50 MG
Camonsertib is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. It demonstrates 30-fold selectivity for ATR over mTOR and over 2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases, exhibiting potent antitumor activity.
- Orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM.
- Demonstrates 30-fold selectivity for ATR over mTOR.
- Exhibits potent antitumor activity.
- Inhibits CHK1(Ser345) phosphorylation in LoVo cells.
- Produces dose-dependent tumor growth inhibition in xenografts.
- Shows greater anti-tumor effects in combination with PARPi Olaparib.
Medchemexpress LLC HN37 | 1821222-10-9 | 99.5% | 340.39 g/mol | C20H21FN2O2 | 5 MG
HN37 is a small-molecule research compound that functions as a potent activator of the KCNQ2 potassium channel. It contains an alkyne moiety suitable for click-chemistry derivatization and is intended for in vitro pharmacology and chemical biology applications.
- Potent KCNQ2 activation with EC50 of 37 nM.
- Alkyne functional group suitable for copper-catalyzed azide-alkyne cycloaddition.
- High reported purity for reproducible assay performance.
- Soluble in DMSO at 50 mg/mL for preparation of concentrated stocks.
- Available in multiple milligram quantities for research use.
Medchemexpress LLC Swertisin | 6991-10-2 | 5 MG
Swertisin is an oral adenosine A1 receptor antagonist and an SGLT2 inhibitor. It exhibits anti-diabetic and antioxidant properties, inhibits HBV, and improves cognitive and memory impairments in mice.
- Acts as an oral adenosine A1 receptor antagonist and SGLT2 inhibitor
- Exhibits anti-diabetic and antioxidant properties
- Inhibits HBV
- Improves cognitive and memory impairments
- Inhibits glucose uptake in HEK293 cells
- Suppresses HBsAg, HBeAg, and HBV DNA levels
- Reduces SGLT2 expression and lowers blood sugar in vivo
Medchemexpress LLC Toringin | 1329-10-8 | 99.6% | 416.38 g/mol | C21H20O9 | 10 MG
Toringin is a natural bioflavonoid isolated from the bark of Docyniopsis tschonoski, supplied for research use as a white-to-yellow solid (CAS 1329-10-8). The compound is offered in small research pack sizes and is accompanied by a product data sheet and safety data sheet.
- Natural bioflavonoid isolated from Docyniopsis tschonoski.
- White to yellow solid suitable for analytical and biological research.
- Reported high purity (approximately 99.6%).
- Supplied as a 10 mg vial for small-scale experiments.
- Documentation available: product data sheet and safety data sheet.
- Recommended storage: powder at -20°C; in solvent, -80°C for long-term storage.
eMolecules 1246998-10-6 | 2-(Pentafluorosulfur)aniline | J&W PharmLab LLC | MFCD21362226 | 219.170 | C6H6F5NS | 96.000 | Nc1ccccc1S(F)(F)(F)(F)F | 50mg | 722712393
2-(Pentafluorosulfur)aniline | J&W PharmLab LLC | 1246998-10-6 | MFCD21362226 | 219.170 | C6H6F5NS | 96.000 | Nc1ccccc1S(F)(F)(F)(F)F | 50mg | 722712393
eMolecules 1523618-10-1 | ChemScene | 4-(Cyclopropylsulfonimidoyl)aniline | 100mg | 761283903 | CS-0184344 | MFCD27987215 | 196.27 | C9H12N2OS
Medchem Express | -Lactamase-IN-2 | 5mg | 582658792 | HY-138247 | 2114651-20-4 | 208.188 | C11H9FO3
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Medchemexpress LLC 1-(2-chloroethyl)-3-((1R,4R)-4-hydroxycyclohexyl)-1-nitrosourea-d4 | 00-00-0 | 99.0% | 253.72 | C9H12D4ClN3O3 | 5 MG
Deuterium-labeled trans-4'-Hydroxy CCNU Lomustine-d4 is a research-grade labeled analogue of trans-4'-Hydroxy lomustine intended for use as a tracer and internal standard in quantitative analytical methods. The product is supplied as a high-purity solid in a 5 MG vial and requires cold storage to maintain stability.
- Deuterium-labeled internal standard for NMR, GC-MS, and LC-MS.
- High purity (99.0%).
- Solid, white to off-white appearance.
- Suitable as a tracer for pharmacokinetic and metabolic studies.
- Powder storage: -20°C for long-term stability; in solvent: -80°C for short-term stability.
- Supplied as a 5 MG vial for laboratory use.
Medchemexpress LLC Toringin | 1329-10-8 | 5 MG
Toringin is a bioflavonoid isolated from the bark of Docyniopsis tschonoski. It decreases the cis-effect of expanded CTG repeats and cytotoxicity, and rescues PC12 neuronal cells when exposed to isosakuranetin. As a flavonoid, Toringin exhibits various biological activities beneficial against conditions such as cancers and coronary heart disease, and is effective in ameliorating RNA gain of function caused by expanded CTG repeats.
- Decreases cis-effect of expanded CTG repeats
- Decreases cytotoxicity
- Rescues PC12 neuronal cells
- Ameliorates RNA gain of function
- Exhibits various biological activities
- Beneficial against cancers and coronary heart disease
eMolecules 50893-53-3 | 1-Chloroethyl chloroformate | Oakwood Chemical | MFCD00000647 | 142.960 | C3H4Cl2O2 | 99.000 | CC(Cl)OC(Cl)=O | 1kg | 537678299
1-Chloroethyl chloroformate | Oakwood Chemical | 50893-53-3 | MFCD00000647 | 142.960 | C3H4Cl2O2 | 99.000 | CC(Cl)OC(Cl)=O | 1kg | 537678299
eMolecules 407-24-9 | Bistrifluoroacetamide | Combi-Blocks, Inc. | MFCD00013564 | 209.047 | C4HF6NO2 | 98.000 | FC(F)(F)C(=O)NC(=O)C(F)(F)F | 25g | 586077145
Bistrifluoroacetamide | Combi-Blocks, Inc. | 407-24-9 | MFCD00013564 | 209.047 | C4HF6NO2 | 98.000 | FC(F)(F)C(=O)NC(=O)C(F)(F)F | 25g | 586077145
eMolecules 1122-96-9 | AstaTech | 4-METHOXYPYRIDINE 1-OXIDE | 5g | 233625492 | 34702 | 95 | MFCD00006207 | 125.127 | C6H7NO2
Medchem Express | Delta-Tocopherol | 50mg | 482204049 | HY-113026 | 119-13-1 | MFCD20486794 | 402.663 | C27H46O2
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![Medchemexpress LLC 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide | 1451994-10-7 | 99.3% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234776.png-250.jpg)
Medchemexpress LLC 5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide | 1451994-10-7 | 99.3% | 50 MG
VU0467485 (AZ13713945) is a potent, selective, orally bioavailable positive allosteric modulator of the muscarinic acetylcholine receptor M4, provided as a research reagent for receptor pharmacology and preclinical studies.
- Potent and selective M4 positive allosteric modulator.
- Orally bioavailable properties support in vivo evaluation.
- High purity suitable for pharmacological assays.
- Available in multiple pack sizes, including 50 mg.
- Commonly used for studies of M4 signaling and antipsychotic-like activity in preclinical models.
Medchemexpress LLC Mizagliflozin | 666843-10-3 | 99.2% | 564.67 | 5 MG
Mizagliflozin (DSP-3235 free base) is a potent, orally active, and selective SGLT1 inhibitor with a Ki of 27 nM for human SGLT1. It shows 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. It also exhibits potential in the amelioration of chronic constipation.
- Potent, orally active, and selective SGLT1 inhibitor (Ki of 27 nM for human SGLT1)
- 303-fold selectivity over SGLT2
- Solid appearance, off-white to light yellow color
- Used as an antidiabetic agent to modify postprandial blood glucose excursion
- Exhibits potential in the amelioration of chronic constipation
Medchemexpress LLC CDC25B-IN-1 | 2374831-10-2 | 98.1% | 321.37 g/mol | C20H19NO3 | 50MG
CDC25B-IN-1 is a small-molecule research inhibitor of the cell division cycle 25B (CDC25B) phosphatase. It has a reported Ki of approximately 8.5 μM, reduces cell proliferation and colony formation, and increases the proportion of cells in the G2/M phase. The compound is supplied at high reported purity and is available in multiple pack sizes, including mg quantities and as a DMSO solution suitable for biochemical and cell-based assays.
- Potent inhibitor of CDC25B phosphatase with reported Ki ≈ 8.5 μM.
- Inhibits cell proliferation and colony formation in cellular assays.
- Causes accumulation of cells in the G2/M phase.
- Supplied with high reported purity for research use.
- Available in multiple pack sizes and as a DMSO solution for convenience.