Alcohols and polyols
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- (464)
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Filtered Search Results
Medchemexpress LLC Alpelisib (hydrochloride) | 1584128-91-5 | C19H23ClF3N5O2S | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor. It demonstrates antineoplastic activity and effectively inhibits common PIK3CA somatic mutations.
- Potent, orally active, and selective PI3Kα inhibitor
- Effectively inhibits common PIK3CA somatic mutations
- Potently inhibits Akt phosphorylation in PI3Kα-transformed cells
- Induces G0/G1 phase cell cycle arrest in osteosarcoma cells
- Significantly reduces tumor volumes in osteosarcoma animal models
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) | 125941-87-9 | 99.8% | 324.24 | 1 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SCH-23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist, also acting as a potent human 5-HT2C receptor agonist. It binds with high affinity to various serotonin receptors and inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels. This compound can reverse inhibitory effects on NLRP3 expression and inflammasome pathways in BV-2 cells, and has been used in studies of neurological disorders like psychosis and Parkinson's disease.
- Potent and selective dopamine D1-like receptor antagonist
- Potent and high efficacy human 5-HT2C receptor agonist
- Binds with high affinity to 5-HT2 and 5-HT1C receptors
- Inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels
- Used in studies of neurological disorders like psychosis and Parkinson's disease
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | MFCD31731608 | 99.9% | 430.32 g/mol | C20H23Cl2F2N3O | 10 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Befiradol hydrochloride is a selective 5-HT1A receptor agonist provided for research use. It modulates serotonergic and dopaminergic activity in cortical regions and is used in preclinical pharmacology studies to investigate 5-HT1A-mediated mechanisms and models of neurological disorders. The material is supplied with supporting documentation for analytical and safety purposes.
- Selective 5-HT1A receptor agonist for receptor pharmacology studies.
- Demonstrated activity on dorsal raphe and medial prefrontal cortex neurotransmission.
- High chemical purity suitable for analytical and in vivo research.
- Supplied with certificate of analysis and safety data sheet.
- Available in multiple pack sizes for small-scale and bulk use.
- Not for human or clinical use; for research use only.
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Accela Chembio Inc Trans-(1r | 2r)-2-aminocyclopentanol Hydrochloride | 5g | 68327-11-7 | MFCD09834692 | 95+% | Shelf Life: 1260 Days | Light Sensitive/moisture Sensitive/+4
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Trans-(1r | 2r)-2-aminocyclopentanol Hydrochloride | 5g | 68327-11-7 | MFCD09834692 | 95+% | Shelf Life: 1260 Days | Light Sensitive/moisture Sensitive/+4
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Accela Chembio Inc Trans-(1r | 2r)-2-aminocyclopentanol Hydrochloride | 1g | 68327-11-7 | MFCD09834692 | 95+% | Shelf Life: 1260 Days | Light Sensitive/moisture Sensitive/+4
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Trans-(1r | 2r)-2-aminocyclopentanol Hydrochloride | 1g | 68327-11-7 | MFCD09834692 | 95+% | Shelf Life: 1260 Days | Light Sensitive/moisture Sensitive/+4
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Aobchem AOBCHEM
5001004812 1- PHENYLETHYNYL CYCLOPENTANOL
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Aobchem AOBCHEM
5001005592 1- FURAN-3-YL CYCLOPENTANOL 25
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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG
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EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.
- Effective and selective DOT1L inhibitor
- Reduces H3K79me2 and H3K79me1 levels
- Down-regulates HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cell proliferation
- Promotes differentiation and apoptosis of leukemia cells
- Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
- Demonstrates selectivity over other histone methyltransferases (HMTs)
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eMolecules 29671-92-9 | Chloroformamidine hydrochloride | Oakwood Chemicals | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
Chloroformamidine hydrochloride | Oakwood Chemicals | 29671-92-9 | MFCD00035527 | 114.960 | CH4Cl2N2 | 97.000 | Cl.NC(Cl)=N | 1g | 480138803
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Medchemexpress LLC Amelparib hydrochloride | 98.4% | 379.88 | 10 MG
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Amelparib hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. It inhibits PARP-1 activity and cellular PAR formation, acting as a potential neuroprotective agent.
- Potent, orally active, and water-soluble inhibitor of PARP-1
- Inhibits PARP-1 activity (IC50 = 18.5 nM)
- Inhibits cellular PAR formation (IC50 = 10.7 nM)
- Potential neuroprotective agent
- Potential for the research of acute ischaemic stroke
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Aobchem AOBCHEM
5001037376 1- P-TOLYL CYCLOPENTANOL 1G
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U.S. Pharmacopeia Alprostadil | 745-65-3 | MFCD00077860 | 25mg
Alprostadil | Mol Wt: 354.484 | 745-65-3 | MFCD00077860 | 25mg
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eMolecules 17356-19-3 | 1-Ethynylcyclopentanol | AA Blocks LLC | MFCD00001365 | 110.156 | C7H10O | 0.000 | OC1(CCCC1)C#C | 1g | 433204950
1-Ethynylcyclopentanol | AA Blocks LLC | 17356-19-3 | MFCD00001365 | 110.156 | C7H10O | 0.000 | OC1(CCCC1)C#C | 1g | 433204950
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Medchemexpress LLC Sovesudil hydrochloride | 2984963-50-8 | 99.5% | 443.90 | 25 MG
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Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. It lowers intraocular pressure (IOP) without inducing hyperemia.
- Potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor
- IC50s of 3.7 nM for ROCK-I and 2.3 nM for ROCK-II
- Lowers intraocular pressure (IOP) without inducing hyperemia
- Induces altered cellular behavior of human trabecular meshwork (HTM) cells in vitro
- Effectively reduces IOP in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia in vivo
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Medchemexpress LLC SB-408124 Hydrochloride | 1431697-90-3 | 98.8% | C19H19ClF2N4O | 50 MG
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SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) antagonist, which has demonstrated potent activity with Ki values of 57 nM and 27 nM in whole cell and membrane assays, respectively. It exhibits a high degree of specificity, showing 50-fold selectivity over the OX2 receptor. This compound is intended for research purposes only and is not sold to patients.
- Selective non-peptide orexin receptor 1 (OX1) antagonist.
- Ki values of 57 nM (whole cell) and 27 nM (membrane).
- Exhibits 50-fold selectivity over OX2 receptor.
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