Sulfoxides
Medchemexpress LLC Cytochrome P450 1B1 Antibody (YA1836) | 100 UL
The Cytochrome P450 1B1 Antibody (YA1836) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically designed to target Cytochrome P450 1B1. This antibody is intended for research use only.
- Rabbit-derived recombinant monoclonal IgG antibody
- Targets Cytochrome P450 1B1
- Predicted and observed molecular weight: 61 kDa
- Species reactivity: Human, mouse, rat
- Applications include Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), and Flow Cytometry (FC)
- Purified by affinity chromatography
- Formulated in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Stable for 1 year when stored at -20°C; avoid repeated freeze/thaw cycles
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 50 UL
Cytochrome P450 24A1 Antibody (YA2121) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically targeting Cytochrome P450 24A1. This antibody is intended for research use only. Cytochrome P450 24A1 is a monooxygenase crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol via C24- and C23-oxidation pathways.
- Host: Rabbit
- Clonality: Monoclonal
- Conjugation: Non-conjugated
- Isotype: IgG
- Appearance: Liquid
- Purity: Affinity chromatography
- Application: Western blot (WB)
- Dilution ratio: 1:500-1:1000
- Species reactivity: Human
- Molecular weight: 59 kDa (predicted and observed)
- Subcellular localization: Mitochondrion
- Research field: Cardiovascular
Medchemexpress LLC (R)-Sulforaphane | 142825-10-3 | 99.95% | 177.29 | 5 MG
(R)-Sulforaphane is an orally active and potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. It primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. This compound modulates gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1.
- Can be used in studies of tumor biology, antioxidant defense mechanisms, inflammation, and immune responses
- Promotes transcription of tumor-suppressing proteins
- Effectively inhibits HDAC activity
- Offers cardiac protection by activating the Keap1/Nrf2/ARE pathway and inducing HO-1 expression
- Suppresses high glucose-induced pancreatic cancer via AMPK-dependent signal transmission
- Storage at -20°C, protect from light, stored under nitrogen
- Unstable in solutions, freshly prepared is recommended
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 5 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor. It has Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH. This compound can be used in studies related to cancer, deleterious inflammatory cascades in neurodegenerative diseases, and COVID-19 infection.
- Dual-targeting modulator: acts as a CB2R agonist and FAAH inhibitor.
- Can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
- At 10 μM, it reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages.
Medchemexpress LLC LRH-1 agonist-2 | 2244781-29-9 | 98.6% | 464.66 | 5 MG
LRH-1 agonist-2 | 2244781-29-9 | 98.6% | 464.66 | 5 MG
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC 2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG