Sulfoxides
TARGETMOL CHEMICALS INC SULINDAC SULFIDE 10MG
Also available in 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 uM. It is an active metabolite of sulinic acid. purity: 99%
TARGETMOL CHEMICALS INC TETRABENAZINE METABOLITE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tetrabenazine Metabolite ((-)-(beta)-HTBZ) a vesicles monoamine transporter 2 (VMAT2) inhibitor is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders. purity: 95%
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Medchemexpress LLC Iduronate 2-sulfatase | 50936-59-9 | >95.0% | 500 UG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized as an active, His-tagged protein for biochemical and enzymatic studies. It hydrolyzes the C2-sulfate ester of glycosaminoglycans and is provided with validated purity and activity specifications.
- Expressed in HEK293 cells.
- C-terminal 10xHis tag for purification.
- Purity >95.0% by reducing SDS-PAGE.
- Specific activity 6.123 pmoL/min/μg (PNCS substrate assay).
- Lyophilized from 0.22 μm filtered PBS, pH 7.4.
- Approximate molecular weight 75-95 kDa due to glycosylation.
- Store at -20°C; after reconstitution stable at 4°C for 1 week.
- Available in a 500 μg size.