Sulfoxides
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 1 ML
CB2R/FAAH modulator-3 is a dual-targeting modulator that functions as a Cannabinoid receptor 2 (CB2R) agonist and a Fatty Acid Amide Hydrolase (FAAH) inhibitor. This modulator demonstrates a high affinity for CB2R with a Ki value of 20.1 nM, and a lower affinity for CB1R with a Ki value of 67.6 nM. It inhibits FAAH with an IC50 value of 3.4 μM. In in vitro studies, at a concentration of 10 μM, it has been shown to reduce the production of pro-inflammatory cytokines, including TNFα, IFN-γ, IL-1β, and IL6, in unstimulated monocytes and macrophages.
- Suitable for use in research related to various conditions, such as cancer.
- Suitable for use in research related to inflammatory cascades associated with neurodegenerative diseases.
- Suitable for use in research related to COVID-19 infection.
TARGETMOL CHEMICALS INC TETRABENAZINE METABOLITE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tetrabenazine Metabolite ((-)-(beta)-HTBZ) a vesicles monoamine transporter 2 (VMAT2) inhibitor is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders. purity: 95%
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 10MM/1ML
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site.
- Enhances GLP-1 binding to GLP-1R
- Operates via a transmembrane site
- Purity of 98.7%
Medchemexpress LLC Ramelteon metabolite M-II-d3 | 1246812-22-5 | 99.8% | 278.36 | C16H18D3NO3 | 1 MG
Ramelteon metabolite M-II-d3 is the deuterium-labeled form of Ramelteon metabolite M-II, provided for use as an internal standard or tracer in quantitative analytical methods. It is intended for analytical and research applications where a labeled reference compound improves accuracy and precision in mass spectrometry and NMR workflows.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS applications.
- High reported purity for accurate quantitation (≈99.8%).
- Provided in milligram-scale pack sizes for analytical use.
- Molecular weight 278.36 and chemical formula C16H18D3NO3.
Medchemexpress LLC Yk-2168 | 2571068-74-9 | 98.1% | 315.80 | 1 ML
YK-2168 is a potent and selective CDK9 inhibitor (IC50 of 5.9 nM) that targets the pS2-RNA Pol II C-terminal domain. It induces apoptosis, suppresses CDK9-regulated genes like MYC and Mcl1, and inhibits tumor growth in CDX mice models. This compound is suitable for cancer research, particularly leukemia.
- Potent and selective CDK9 inhibitor (IC50 of 5.9 nM).
- Induces apoptosis and suppresses CDK9-regulated genes.
- Inhibits tumor growth in CDX mice models (80% inhibition at 10 mg/kg).
- Highly selective over CDK1 and CDK2, with no hERG channel inhibition up to 30 μM.
- Reduces pS2-RNA Pol II CTD levels and upregulates cleaved caspase 3.
- Demonstrates good safety in vivo with no significant body weight changes.
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 5 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is utilized in cancer research.
- Cytotoxicity against human COLO320 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
- Cytotoxicity against human MIAPaCa2 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 87.3% | 250 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotes. It targets the outer membrane of Gram-negative bacteria and serves as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly suppresses growth of eukaryotes, such as fungi
- Sensitizes resistant Escherichia coli strains by eliminating outer membrane resistance
- Mixture of several Streptothricins (primarily D and F)
- Can create channels in the outer membrane
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | MFCD00869764 | 99.88% | 250 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM).
- Selectively reduces Aβ42 production.
- Useful for Alzheimer's disease research.
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 100 MG
GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). It is intended for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Suitable for research applications
- Targets glucagon receptor (GCGR)
- Relevant for inflammation or immune system disease research
- Relevant for metabolic or endocrine disease research
- Relevant for digestive system disease research
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.05% | 315.80 | 50 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits the phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. This product can be used for cancer research, including leukemia.
- Potently inhibits purified CDK9 enzymatic activity
- Exhibits high selectivity over CDK1 and CDK2
- Inhibits proliferation of MV4-11 leukemia cells
- Induces dose-dependent inhibition of tumor growth in CDX mice models
- Suppresses CDK9-regulated gene expression
- Upregulates cleaved caspase 3, indicating induced apoptosis
- Maintains a good safety profile in vivo with no significant body weight changes
Medchemexpress LLC Kv3.1 modulator 2 | 3035827-42-7 | 99.8% | 437.88 | 25 MG
Kv3.1 modulator 2 is a Kv3.1 channels modulator with an EC50 value of 68 nM. It is for research use only and not sold to patients. This compound is a solid, appearing white to off-white, and has detailed storage and solubility protocols for various applications.
- Kv3.1 channels modulator
- EC50 value of 68 nM
- Solid, white to off-white appearance
- Specific storage recommendations for powder and in solvent
- Detailed solubility information for in vitro and in vivo use
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | C20H18CINO3S | 50 MG
GPR120 modulator 2 | 1050506-87-0 | 97.1% | C20H18CINO3S | 50 MG
Medchemexpress LLC IL-17A modulator-3 | 2467732-95-0 | 99.37% | 639.80 | 5 MG
IL-17A modulator-3 (compound 253) is an IL-17A modulator. It inhibits IL-17A/A with an IC50 value of <10 μM. It can be used for the research of inflammation, cancer, and autoimmune diseases.
- Can be used for the research of inflammation
- Can be used for the research of cancer
- Can be used for the research of autoimmune diseases
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 1 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. It is used in cancer research.
- Inhibits mTORC1 pathway
- Metabolite of Sulindac
- Inhibits colon cancer cell growth
- Induces cell cycle arrest
- Used in cancer research