Sulfoxides
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.47% | C24H28N2O3 | 100 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM). It is intended for research use only.
- Available as a solid, white to off-white in color.
- Soluble in DMSO at 100 mg/mL.
- Shipped at room temperature in continental US.
Medchemexpress LLC Fast garnet GBC sulfate salt | 101-89-3 | MFCD00011883 | 90.0% | 334.35 g/mol | C14H14N4O4S | 50 MG
Fast garnet GBC sulfate salt, 90% is an azo diazonium dye used as a chromogenic substrate for alkaline phosphatase in histochemical staining and related enzymatic assays. It is supplied as a sulfate salt with high dye content suitable for laboratory staining protocols.
- Chromogenic substrate for alkaline phosphatase staining
- High dye content, formulated at 90.0% purity
- Suitable for histochemistry and enzyme activity assays
- Available in small laboratory-scale quantities
- Solid form with molecular formula C14H14N4O4S
Medchemexpress LLC (+)-LRH-1 modulator-1 | 2244781-29-9 | 99.38% | 464.66 | 50 MG
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1, a potent LRH-1 (liver receptor homolog-1) modulator/agonist. It exhibits anti-inflammatory effects in intestinal organoids by inducing the anti-inflammatory cytokine IL-10 and reducing the inflammatory cytokines IL-1b and TNFa.
- Potent LRH-1 modulator/agonist
- Exhibits anti-inflammatory effects in intestinal organoids
- Induces anti-inflammatory cytokine IL-10
- Reduces inflammatory cytokines IL-1b and TNFa
- Pure form storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Shipping conditions: Room temperature if less than 2 weeks
Medchemexpress LLC Ritonavir metabolite (Desthiazolylmethyloxycarbonyl Ritonavir) | 176655-55-3 | 99.6% | 579.80 | 5 MG
Ritonavir metabolite is a metabolite of Ritonavir, which is an HIV protease inhibitor. The product appears as a white to off-white solid.
- Purity of 99.6%
- Molecular weight of 579.80
- CAS number 176655-55-3
- Storage at -20°C for powder, -80°C for 6 months in solvent
- Shipping at room temperature in continental US
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Medchemexpress LLC Triclabendazole sulfoxide | 100648-13-3 | 98.8% | 375.66 | 100 MG
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole. It exhibits anti-parasite effects and can inhibit the membrane transporter ABCG2/BCRP.
- Main plasma metabolite of Triclabendazole.
- Exhibits anti-parasite effects.
- Inhibits membrane transporter ABCG2/BCRP.
- Targets parasite, BCRP, and PDGFR.
- Involved in anti-infection, membrane transporter/ion channel, and protein tyrosine kinase/RTK pathways.
Medchemexpress LLC 2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
Medchemexpress LLC Niraparib carboxylic acid metabolite M1 | 1476777-06-6 | 99.7% | 321.37 g/mol | C19H19N3O2 | 10 MG
Niraparib metabolite M1 is the primary carboxylic acid metabolite of the PARP inhibitor niraparib, provided as a solid research reagent for in vitro and analytical use.
- High purity (99.69%) suitable for analytical and research applications.
- Molecular formula C19H19N3O2; molecular weight 321.37 g/mol.
- Solid, light brown to brown appearance.
- Supplied at 10 mg quantity.
- Soluble in DMSO at ≥ 100 mg/mL (in vitro).
- Recommended storage: powder at -20°C (up to 3 years); in solvent at -80°C (up to 2 years).
- Intended for laboratory research use only; not for human therapeutic use.
Medchemexpress LLC GPR120 modulator 1 | 1050506-75-6 | 98.1% | 389.85 g/mol | C19H16ClNO4S | 10 MG
GPR120 modulator 1 is a small-molecule research compound used to modulate G protein-coupled receptor 120 (GPR120) in studies of metabolic and inflammatory pathways. It is intended for in vitro and preclinical research use and is supplied as a purified solid with reported purity suitable for biochemical assays.
- Small-molecule modulator of GPR120 for receptor biology studies.
- High reported purity for reliable assay performance.
- Available in small pack sizes suitable for screening and characterization.
- Provided with supporting documents including datasheet and safety information.
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC Sodium butane-1-sulfonate | 2386-54-1 | MFCD00007540 | 98.0% | 160.17 g·mol⁻¹ | C4H9NaO3S | 100 MG
Sodium butane-1-sulfonate is the sodium salt of 1-butanesulfonic acid used as a reagent in chromatographic and analytical workflows. It is water-soluble and commonly employed as a mobile phase additive to improve separation of arsenic and selenium species in HPLC and related methods. Typical specifications include a molecular weight of 160.17 g·mol⁻¹ and high purity suitable for analytical applications.
- Water-soluble sodium salt suitable for aqueous mobile phases.
- Facilitates chromatographic separation of arsenic and selenium compounds.
- High purity for analytical and HPLC applications.
- Available in small-scale lab pack sizes for research use.
- Stable solid form with molecular weight 160.17 g·mol⁻¹.
