Sulfoxides
Medchemexpress LLC Sirtuin modulator 3 25mg | 25mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
![Medchemexpress LLC Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | 2671063-84-4 | 98.0% | C21H20F3N3O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260935.png-250.jpg)
Medchemexpress LLC Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | 2671063-84-4 | 98.0% | C21H20F3N3O3 | 10MG
mGluR2 modulator 1 is a research-grade positive allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2), used in in vitro and in vivo pharmacology studies. It is reported to be brain-penetrant and displays potent receptor activity suitable for mechanistic and preclinical research.
- Potent mGluR2 positive allosteric modulator (EC50 ≈ 0.03 μM).
- Brain-penetrant profile suitable for in vivo studies.
- High purity for research applications.
- Soluble in DMSO (50 mg/mL); in vivo vehicle options documented.
- Stable when stored protected from light at recommended temperatures.
- Supplied as a white to off-white solid for handling and formulation.
Medchemexpress LLC Sirtuin modulator 3 5mg | 5mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | MFCD29924722 | 99.9% | 10 MG
Sirtuin modulator 1 is a small-molecule modulator of SIRT1 (a homolog of SIRT3) reported with an EC1.5 of <1 μM and described in patent WO 2010071853 A1 (Compound No. 4). Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies of sirtuin activity.
- High reported purity for assay-ready use.
- Molecular formula C31H32ClN5O2S2, molecular weight 606.20 g/mol.
- CAS number 2070015-26-6 for unambiguous identification.
- Reported EC1.5 potency of <1 μM against SIRT1.
- Available in milligram-scale quantities suitable for research.
Medchemexpress LLC Triclabendazole sulfoxide (TCBZ-SO) | 100648-13-3 | 98.8% | 375.66 | 25 MG
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole. It exhibits anti-parasite effects and can inhibit the membrane transporter ABCG2/BCRP.
- Main plasma metabolite of Triclabendazole
- Exhibits anti-parasite effects
- Inhibits the membrane transporter ABCG2/BCRP
- Useful in infection disease research
- Useful in cancer disease research
- Useful in parasitic infection research
Medchemexpress LLC Kv3 modulator 2 | 2101321-76-8 | 99.9% | 379.41 g·mol⁻¹ | C21H21N3O4 | 5 MG
Kv3 modulator 2 is a small-molecule modulator of Kv3 voltage-gated potassium channels with reported analgesic activity. It is provided for laboratory research use and is characterized by a defined molecular formula and molecular weight, and high purity suitable for preclinical studies.
- High purity (99.9%).
- Available in small research quantities (example: 5 mg).
- Molecular formula C21H21N3O4; molecular weight 379.41 g·mol⁻¹.
- Reported Kv3 channel modulatory activity with analgesic effects.
- For research use only; not for human or clinical use.
Medchemexpress LLC Sirtuin modulator 3 10mg | 10mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC Autotaxin modulator 1 | 1548743-69-6 | 99.4% | 10 MG
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. It is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.
- Autotaxin (ATX) enzyme inhibitor
- Useful for researching demyelination due to injury or disease
- Useful for researching proliferative disorders such as cancer
- For research use only
- Appears as a white to off-white solid
- Soluble in DMSO (100 mg/mL)
Apexbio Technology LLC Sulforaphane(Synonyms: Broccoli sulforaphane, DL-Sulforaphane, R-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane), 50mg, CAS: 4478-93-7.
Sulforaphane (CAS 4478-93-7) is a naturally occurring isothiocyanate abundantly found in vegetables especially broccoli It acts primarily through activation of the Keap1-Nrf2 signaling pathway enhancing cellular defense against oxidative and electrophilic stress Sulforaphane has demonstrated antiproliferative activity in vitro as shown by dose-dependent cell cycle arrest at G2/M and apoptosis induction in HT29 human colon carcinoma cells Such effects involve elevated cyclin A and B1 levels increased pro-apoptotic Bax expression mitochondrial cytochrome c release and poly(ADP-ribose) polymerase cleavage These properties make sulforaphane relevant for investigating cancer chemoprevention and cellular stress responses
![Medchemexpress LLC 4-Thiazolecarboxamide, 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-,hydrochloride | 2070015-26-6 | 99.85% | 606.20 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403398-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 4-Thiazolecarboxamide, 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-,hydrochloride | 2070015-26-6 | 99.85% | 606.20 | 25 MG
Sirtuin modulator 1 is a modulator of SIRTl, a homolog of SIRT3, with EC1.5 of < 1 μM. It was extracted from patent WO 2010071853 A1, Compound No.4.
- Modulates SIRTl, a homolog of SIRT3.
- Has an EC1.5 of less than 1 μM.
- Extracted from patent WO 2010071853 A1.
- Identified as Compound No.4 in the patent.
Medchemexpress LLC 3-isoxazolecarboxamide, N-(2-cyclohexyl-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazol-4-yl)-4-methyl-5-... | 1825371-51-4 | 99.8% | 446.54 | 1 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with an IC50 of 180 nM. This product is for research use only and not sold to patients.
- Selective inhibitor for Smad ubiquiquitination regulatory factor 1 (Smurf1).
- IC50 of 180 nM.
- For research use only.
- Appearance is a white to off-white solid.
- Specific storage conditions for powder and in solvent.
- Soluble in DMSO.
Medchemexpress LLC Hsp110/sGC-modulator-1 | 99.6% | 490.86 g·mol⁻1 | C24H18ClF3N2O4 | 10 MG
Hsp110/sGC-modulator-1 is an orally active small-molecule regulator that modulates Hsp110 and soluble guanylate cyclase (sGC). It demonstrates potent dual-target activity, produces vasodilatory effects, and attenuates pulmonary vascular remodeling and right ventricular hypertrophy in preclinical studies. Supplied in milligram quantities for research use only. Molecular formula C24H18ClF3N2O4; molecular weight 490.86 g·mol⁻1; reported purity 99.58%.
- Dual-target activity against Hsp110 and sGC.
- Demonstrated vasodilatory and antiproliferative effects in preclinical models.
- Suitable for in vitro and in vivo preclinical research.
- Supplied in milligram quantities for screening and lead optimization.
- Reported purity 99.58% and characterized by HRMS.
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 99.9% | 1 G
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and destroys the outer membrane of Gram-negative bacteria. It also functions as a selective marker for *Fonsecaea pedrosoi* and is effective for a diverse range of organisms including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Destroys outer membrane of Gram-negative bacteria
- Inhibits protein biosynthesis in prokaryotic cells
- Inhibits growth of eukaryotes such as fungi
- Selective marker for *Fonsecaea pedrosoi*
- Used as an elective marker for various organisms
Medchemexpress LLC Nur77 modulator 3 | 2097787-75-0 | 99.0% | 308.40 | 100 MG
Nur77 modulator 3 is a Nur77 modulator that induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. It enhances Nur77-dependent autophagic flux and significantly inhibits the mTORC1 signaling pathway. This modulator can ameliorate HSCs activation, inflammation, and hepatic fibrosis *in vivo*.
- Induces Nur77 expression
- Inhibits hepatic stellate cells (HSCs) activation
- Reduces extracellular matrix (ECM) deposition
- Enhances Nur77-dependent autophagic flux
- Significantly inhibits the mTORC1 signaling pathway
- Ameliorates HSCs activation, inflammation, and hepatic fibrosis *in vivo*
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 5 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. It can be used for the research of cancer, such as leukemia.
- Potent and selective CDK9 inhibitor
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes
- Inhibits tumor growth in CDX mice models
- Suitable for research in cancer, such as leukemia