Sulfoxides
Apexbio Technology LLC INCB024360 analogue 914471-09-3 10mM (in 1mL DMSO)
INCB024360 analogue (CAS 914471-09-3) is a selective inhibitor of indoleamine 2 3-dioxygenase 1 (IDO1) an enzyme responsible for initiating tryptophan catabolism along the kynurenine pathway IDO1-mediated depletion of tryptophan in the tumor microenvironment can suppress T-cell proliferation and promote immune tolerance facilitating cancer immune evasion INCB024360 analogue inhibits human IDO1 with an IC50 of 67 nM and demonstrates minimal activity against the related enzyme TDO In vivo studies in mouse melanoma models reveal dose-dependent anti-tumor activity and significant reductions in kynurenine levels supporting its utility as a research tool to investigate IDO1-targeted immunotherapy strategies
Medchemexpress LLC Hsp110/sGC-modulator-1 | 99.6% | 490.86 g·mol⁻1 | C24H18ClF3N2O4 | 10 MG
Hsp110/sGC-modulator-1 is an orally active small-molecule regulator that modulates Hsp110 and soluble guanylate cyclase (sGC). It demonstrates potent dual-target activity, produces vasodilatory effects, and attenuates pulmonary vascular remodeling and right ventricular hypertrophy in preclinical studies. Supplied in milligram quantities for research use only. Molecular formula C24H18ClF3N2O4; molecular weight 490.86 g·mol⁻1; reported purity 99.58%.
- Dual-target activity against Hsp110 and sGC.
- Demonstrated vasodilatory and antiproliferative effects in preclinical models.
- Suitable for in vitro and in vivo preclinical research.
- Supplied in milligram quantities for screening and lead optimization.
- Reported purity 99.58% and characterized by HRMS.
Medchemexpress LLC Sirtuin modulator 3 100mg | 100mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC Sirtuin modulator 3 5mg | 5mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC Sirtuin modulator 3 10mg | 10mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Sigma Aldrich Fine Chemicals Biosciences Fatty Acid Metabolite Libr1EA
Compounds can either be used as standards and injected individually or a strategy may be employed to pool compounds to allow multiple mixtures to be analyzed per injection.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 50 MG
Mutant p53 modulator-1 is a mutant p53 modulator that reduces the progression of cancers containing a p53 mutation.
- Molecular weight: 576.59
- Appearance: Solid
- Color: Light yellow to brown
- Solubility in DMSO: 100 mg/mL (173.43 mM)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
![Medchemexpress LLC N-[(1S)-1-cycloheptyl-2-[4-[(2R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-(propanoylamino)propyl]anilino] | 2467731-88-8 | 99.5% | C31H45N7O4 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260756.png-250.jpg)
Medchemexpress LLC N-[(1S)-1-cycloheptyl-2-[4-[(2R)-3-(4-methylpiperazin-1-yl)-3-oxo-2-(propanoylamino)propyl]anilino] | 2467731-88-8 | 99.5% | C31H45N7O4 | 10MG
IL-17 modulator 3 is a small-molecule IL-17 pathway modulator intended for research use in studies of inflammation, cancer, and autoimmune diseases. It is provided as a chemically characterized research reagent with documentation of purity and structural identifiers suitable for in vitro and preclinical investigations.
- High purity (99.5%).
- Solid powder with light yellow to yellow appearance.
- Molecular formula C31H45N7O4 and molecular weight 579.73.
- Structural identifiers available (SMILES and PubChem CID documented).
- Supplied in a 10 mg quantity for laboratory research use.
- Intended for use in inflammation, cancer, and autoimmune disease research applications.
![Medchemexpress LLC 2-bromo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]benzeneacetamide | 942296-18-6 | >98.0% | 298.13 g·mol⁻¹ | C12H12BrNO3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000289913.png-250.jpg)
Medchemexpress LLC 2-bromo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]benzeneacetamide | 942296-18-6 | >98.0% | 298.13 g·mol⁻¹ | C12H12BrNO3 | 10 MG
AHL modulator-1 is a small-molecule research reagent that modulates N-acylated L-homoserine lactone (AHL)-mediated bacterial signalling. It is supplied as a high-purity solid for laboratory research and is not for human or animal therapeutic or diagnostic use.
- Modulates AHL-mediated bacterial signalling
- High purity (>98.0%)
- Molecular formula: C12H12BrNO3
- Molecular weight: 298.13 g·mol⁻¹
- Supplied as a 10 mg solid for research use only
![Medchemexpress LLC Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | 2671063-84-4 | 98.0% | C21H20F3N3O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260935.png-250.jpg)
Medchemexpress LLC Pyrazino[1,2-a]benzimidazol-1(2H)-one, 3,4-dihydro-2-[4-[4-(trifluoromethoxy)phenoxy]butyl]- | 2671063-84-4 | 98.0% | C21H20F3N3O3 | 10MG
mGluR2 modulator 1 is a research-grade positive allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2), used in in vitro and in vivo pharmacology studies. It is reported to be brain-penetrant and displays potent receptor activity suitable for mechanistic and preclinical research.
- Potent mGluR2 positive allosteric modulator (EC50 ≈ 0.03 μM).
- Brain-penetrant profile suitable for in vivo studies.
- High purity for research applications.
- Soluble in DMSO (50 mg/mL); in vivo vehicle options documented.
- Stable when stored protected from light at recommended temperatures.
- Supplied as a white to off-white solid for handling and formulation.
Medchemexpress LLC Sirtuin modulator 3 10mM 1mL | 1mL
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]