Sulfoxides
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | 99.85% | 606.20 | 100 MG
Sirtuin modulator 1 is a compound that acts as a modulator of SIRTl, a homolog of SIRT3. This compound has an EC1.5 of less than 1 μM and was extracted from patent WO 2010071853 A1, Compound No.4.
- Modulator of SIRTl, a homolog of SIRT3
- High purity of 99.85%
- Solid appearance, light yellow to yellow color
- Molecular weight of 606.20
- Soluble in DMSO at 12.5 mg/mL
AdipoGen Prosulfocarb sulfoxide
Chemical. CAS 51954-81-5. Formula C14H21NO2S. MW 267.39. Metabolite of the herbicide Prosulfocarb. Can be used as a reference compound.
![Medchemexpress LLC 2-bromo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]benzeneacetamide | 942296-18-6 | >98.0% | 298.13 g·mol⁻¹ | C12H12BrNO3 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000289913.png-250.jpg)
Medchemexpress LLC 2-bromo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]benzeneacetamide | 942296-18-6 | >98.0% | 298.13 g·mol⁻¹ | C12H12BrNO3 | 10 MG
AHL modulator-1 is a small-molecule research reagent that modulates N-acylated L-homoserine lactone (AHL)-mediated bacterial signalling. It is supplied as a high-purity solid for laboratory research and is not for human or animal therapeutic or diagnostic use.
- Modulates AHL-mediated bacterial signalling
- High purity (>98.0%)
- Molecular formula: C12H12BrNO3
- Molecular weight: 298.13 g·mol⁻¹
- Supplied as a 10 mg solid for research use only
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | 99.7% | 341.49 g·mol⁻¹ | C22H31NO2 | 10 MG
CB2R/FAAH modulator-3 is a small-molecule research compound that functions as a cannabinoid receptor 2 (CB2R) agonist and a fatty acid amide hydrolase (FAAH) inhibitor. Reported activity includes CB2R Ki = 20.1 nM, CB1R Ki = 67.6 nM, and FAAH IC50 = 3.4 μM. It is intended for preclinical studies of inflammatory signaling, neurodegeneration, cancer-related pathways, and infection-associated inflammatory responses.
- Dual activity as CB2R agonist and FAAH inhibitor.
- Reported high CB2R affinity (low nanomolar Ki).
- Lower affinity for CB1R supporting receptor selectivity.
- Applicable to studies of inflammation, neurodegeneration, and cancer biology.
- High chemical purity suitable for research use.
- Available in small-mass and solution formats for assay workflows.
Medchemexpress LLC 5-HT1A modulator 2 hydrochloride | 3880-76-0 | 99.69% | 213.70 | 10 MM * 1 ML
5-HT1A modulator 2 hydrochloride is a derivative of 8-OH-DPAT (HY-112061), acting as a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding.
- Modulator of 5-HT1A
- Derivative of 8-OH-DPAT
- Binding Ki of 53 nM for 5-HT1A
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.9% | 1 ML
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. This product is designed for researching Alzheimer's disease.
- Potent γ-secretase modulator
- Selectively reduces Aβ42 production
- Favors shorter Aβ species
- Suitable for Alzheimer's disease research
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Medchemexpress LLC mGluR3 modulator-1 | 374548-18-2 | MFCD01957075 | 98.7% | 271.36 g·mol⁻1 | C16H21N3O | 10 MG
mGluR3 modulator-1 is a small-molecule modulator of the metabotropic glutamate receptor 3 (mGluR3) intended for research use. It demonstrates activity in cellular calcium mobilization assays (EC50 = 1-10 μM) and is supplied with a reported high purity and defined molecular properties suitable for in vitro pharmacology and receptor profiling studies.
- Modulates mGluR3 receptor activity in cell-based assays.
- Demonstrated EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 calcium mobilization assay.
- High purity suitable for research applications.
- Available in small mass packages for screening and assay work.
- Includes chemical identifiers for traceability, such as CAS 374548-18-2.
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 99.9% | 1 G
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and destroys the outer membrane of Gram-negative bacteria. It also functions as a selective marker for *Fonsecaea pedrosoi* and is effective for a diverse range of organisms including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Destroys outer membrane of Gram-negative bacteria
- Inhibits protein biosynthesis in prokaryotic cells
- Inhibits growth of eukaryotes such as fungi
- Selective marker for *Fonsecaea pedrosoi*
- Used as an elective marker for various organisms
Medchemexpress LLC Sulforaphane | 4478-93-7 | MFCD00016766 | 99.0% | 177.29 | 50 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway, promoting transcription of tumor-suppressing proteins and inhibiting HDACs. It protects the heart by activating the Keap1/Nrf2/ARE pathway and inducing HO-1 expression, and suppresses high glucose-induced pancreatic cancer via AMPK-dependent signal transmission. It exhibits both anticancer and anti-inflammatory properties.
- Induces cell cycle arrest and apoptosis.
- Inhibits growth re-initiation and decreases cell viability.
- Reduces apoptotic cells and pro-apoptotic proteins.
- Activates Keap1/Nrf2/ARE pathway and induces HO-1 expression.
- Inhibits mammary tumor formation.
- Reduces incidence and weight of DMBA-induced mammary tumors.
Sigma Aldrich Fine Chemicals Biosciences Fatty Acid Metabolite Libr1EA
Compounds can either be used as standards and injected individually or a strategy may be employed to pool compounds to allow multiple mixtures to be analyzed per injection.
Medchemexpress LLC Pin1 modulator 1 | 301688-74-4 | C18H15NO3S2 | 5 MG
Pin1 modulator 1, identified by CAS number 301688-74-4 and chemical formula C18H15NO3S2, is a laboratory chemical from MedChemExpress. This substance is intended for research use and is stable under recommended storage conditions.
- Identified for laboratory use and manufacture of substances
- Stable under recommended storage conditions
- Solid appearance
![Medchemexpress LLC 4-Thiazolecarboxamide, 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-,hydrochloride | 2070015-26-6 | 99.85% | 606.20 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403398-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 4-Thiazolecarboxamide, 5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(1-pyrrolidinylmethyl)thiazolo[5,4-b]pyridin-2-yl]phenyl]-,hydrochloride | 2070015-26-6 | 99.85% | 606.20 | 25 MG
Sirtuin modulator 1 is a modulator of SIRTl, a homolog of SIRT3, with EC1.5 of < 1 μM. It was extracted from patent WO 2010071853 A1, Compound No.4.
- Modulates SIRTl, a homolog of SIRT3.
- Has an EC1.5 of less than 1 μM.
- Extracted from patent WO 2010071853 A1.
- Identified as Compound No.4 in the patent.