Thioureas
AdipoGen Raptinal
Chemical. CAS 1176-09-6. Formula C28H18O2. MW 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore MPTP formation, suggesting a mitochondrial outer membrane permeabilization MOMP model of cytochrome c release.
AdipoGen YC-1
Chemical. CAS 170632-47-0. Formula C19H16N2O2. MW 304.4. Nitric oxide NO independent, superoxide-sensitive soluble guanylyl cyclase sGC activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.
AdipoGen Alsterpaullone
Chemical. CAS 237430-03-4. Formula C16H11N3O3. MW 293.3. Potent CDK1/cyclin B IC50 = 35 nM inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E IC50 = 200 nM, CDK5/p25 IC50 = 40 nM, CDK5/p35 IC50 = 40 nM. GSK-3beta glycogen synthase kinase-3beta inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.
AdipoGen SB202190
Chemical. CAS 152121-30-7. Formula C20H14FN3O. MW 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen Z-Leu-Arg-Gly-Gly-AMC
Chemical. CAS 167698-68-2 free base. Formula C34H44N8O8 . C2HF3O2. MW 692.8 . 114.0. Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases UCHs, e.g. UCHL3 and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7. Excitation 380nm. Emission 460nm.
AdipoGen Alsterpaullone
Chemical. CAS 237430-03-4. Formula C16H11N3O3. MW 293.3. Potent CDK1/cyclin B IC50 = 35 nM inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E IC50 = 200 nM, CDK5/p25 IC50 = 40 nM, CDK5/p35 IC50 = 40 nM. GSK-3beta glycogen synthase kinase-3beta inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.
AdipoGen Z-Val-Leu-Arg-AMC
Chemical. Formula C35H47N7O7 . C2HF3O2. MW 677.8 . 114.0. Proteasome subunit alpha type-1 Macropain substrate used for assaying the trypsin-like activity of the 20S proteasome. Cysteine proteinase falcipain-2 and falcipain-3 malarial hemoglobinases substrate. Cathepsin S substrate. Hydrolysis of this fluorogenic peptide substrate is monitored by observing fluorescence at an Excitation of 345nm and Emission at 445nm.
AdipoGen Z-Leu-Arg-Gly-Gly-AMC
Chemical. CAS 167698-68-2 free base. Formula C34H44N8O8 . C2HF3O2. MW 692.8 . 114.0. Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases UCHs, e.g. UCHL3 and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7. Excitation 380nm. Emission 460nm.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
Biomatik Corporation Pepstatin A. Grade High Purity. Storage 4C. CAS 8913806
Pepstatin A. Grade High Purity. Storage 4C. CAS 8913806
Biomatik Corporation Pepstatin A. Grade High Purity. Storage 4C. CAS 8913806
Pepstatin A. Grade High Purity. Storage 4C. CAS 8913806
Biomatik Corporation E-64. Grade Biotechnology. Storage -20C. CAS 66701-25-5
E-64. Grade Biotechnology. Storage -20C. CAS 66701-25-5
Chem-Impex International, Inc. Thiourea | 62-56-6 | MFCD00008067 | 1KG
Thiourea, 62-56-6, MFCD00008067, 1KG
eMolecules Ambeed / Tetramethylthiourea / 25g / 588342543 / A393900 / / 2782-91-4 / MFCD00008324 / 132.230 / C5H12N2S
Ambeed / Tetramethylthiourea / 25g / 588342543 / A393900 / / 2782-91-4 / MFCD00008324 / 132.230 / C5H12N2S