Coumarins and derivatives
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 250 MG
4-Hydroxycoumarin is an orally active coumarin derivative, considered one of the most versatile heterocyclic scaffolds, frequently used in the synthesis of various organic compounds. It exhibits both electrophilic and nucleophilic properties. It functions as an HIV protease inhibitor and a tyrosine kinase inhibitor, and it also possesses anti-inflammatory, antibacterial, and anti-tumor effects.
- White to off-white solid
- Purity of 99.26% by HPLC
- Assay of 97.98%
- Loss on drying (LOD) of 1.2%
- Residue on ignition (ROI) of 0.09%
- Recommended storage at 4°C in sealed conditions, away from light and moisture
- Packaged in a brown glass bottle
Medchemexpress LLC Psoralen | 66-97-7 | 99.9% | 186.16 | 100 MG
Psoralen, also known as Ficusin, is a naturally occurring coumarin compound isolated from the seeds of Fructus Psoraleae. It is intended for research use only.
- Exhibits anti-cancer activity.
- Acts as an antioxidant.
- Demonstrates antidepressant properties.
- Possesses antibacterial effects.
- Shows antiviral activity.
Pfaltz & Bauer 7-Hydroxy-4-methylcoumarin 98% 100G | 90-33-5
7-Hydroxy-4-methylcoumarin 98% 100G | 90-33-5
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 250mg
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Cayman Chemical 7-AmIno-4-methylcoumarIn 250mg
A fluorescent probe for peptide labeling commonly used in the study of proteases; conjugation via its amino group to a peptide substrate results in quenching of the fluorescent signal; upon enzymatic cleavage of the peptide by proteases, AMC is released and its fluorescence can be used to quantify enzyme activity; ex/em = 345/445 nm, respectively
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 10 MG
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. It exerts survival effects on pancreatic b-cells and human pancreatic islets comparable to unacylated ghrelin (UAG). It is very stable in human plasma in vitro with no degradation observed after 1 day of incubation at 37°C.
- Prevents body weight increase caused by a high-fat diet in mice
- Prevents high-fat diet-induced proinflammatory effects
- Stimulates mitochondrial function markers in brown adipose tissue
- Prevents the development of a prediabetic metabolic state
- Prevents a high-fat diet-induced increase in acyl ghrelin levels
- Significantly improves glucose concentrations without increasing insulin levels
- Decreases mean body weight by 2.6 kg (vs 0.8 kg for placebo)
- Reduces HbA1c by 0.4% (vs 0.2% for placebo)
Selleck Chemical LLC Palomid 529 (P529) S2238-1g
Palomid 529 (P529 SG 00529) inhibits both the mTORC1 and mTORC2 complexes reduces phosphorylation of pAktS473 pGSK3 S9 and pS6 Phase 1
Pfaltz & Bauer 7-Diethylamino-4-methylcoumari 100G | 91-44-1
7-Diethylamino-4-methylcoumari 100G | 91-44-1
Medchemexpress LLC 6-Bromocoumarin | 19063-55-9 | 225.04 | 1 G
6-Bromocoumarin is a potential anti-bacterial agent that exhibits affinity for α and β estrogen receptors. It does not inhibit 17β-HSD1 and is intended for research use only.
- Potential anti-bacterial agent
- Exhibits affinity for α and β estrogen receptors
- Does not inhibit 17β-HSD1
- High purity of 98.51%
- White to off-white solid appearance
- Molecular weight of 225.04
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 5mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | MFCD00006880 | 25 G
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6, significantly decreasing ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage. It also restores total protein and albumin levels in serum while preventing oxidative stress, and can decline mitotic activity of *A. sativum* promeristem.
- Coumarin derivative
- Potent hepatoprotective and antioxidant properties
- Mechanism-based inhibitor for CYP2A6
- Decreases ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage
- Restores total protein and albumin levels in serum
- Prevents oxidative stress
- Can decline mitotic activity of *A. sativum* promeristem
- Purity: 99.34%
- Appearance: Solid, white to off-white