Coumarins and derivatives
Sigma Aldrich Fine Chemicals Biosciences 7-Ethoxycoumarin | 31005-02-4 | MFCD00006877 | 25mg
7-Ethoxycoumarin | Purity: 99% | Mol Wt: 190.2 | 31005-02-4 | MFCD00006877 | 25mg
Medchemexpress LLC Coumarin | 91-64-5 | 146.15 | 500 MG
Coumarin is a potent and orally active anti-inflammatory agent. It demonstrates an antinociceptive effect, as well as antibacterial, antifungal, and anticancer activities.
- Potent and orally active anti-inflammatory agent.
- Shows an antinociceptive effect.
- Exhibits antibacterial activity.
- Exhibits antifungal activity.
- Exhibits anticancer activity.
Medchemexpress LLC Coumarin | 91-64-5 | 146.15 | 5 G
Coumarin is a potent and orally active anti-inflammatory agent. It also demonstrates antinociceptive, antibacterial, antifungal, and anticancer activities.
- Potent and orally active anti-inflammatory agent
- Shows antinociceptive effect
- Shows antibacterial, antifungal and anticancer activity
Cayman Chemical 7-EthoxycoumarIn 100mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
AdipoGen Coumarin 334
Chemical. CAS 55804-67-6. Formula C17H17NO3. Molecular Weight 283.32. Coumarin 334 is a laser dye with an absorption maximum of 452nm. It is used as starting material for the synthesis of cysteine-selective or pH indicator fluorescent probes. Spectral data lambdamax 452nm, epsilon extinction coefficient >45000 at 449-455 nm in ethanol, lambdalaser 532nm.
AdipoGen Benzothiazolyl-2EtN coumarin
Chemical. CAS 38215-36-0. Formula C20H18N2O2S. MW 350.43. Synthetic. Fluorescent dye which is widely used for staining polymer particles, but also organelles or materials used in medicine.
eMolecules 2187435-45-4 | (4-(Ethylamino)-6-fluoropyridin-3-yl)methanol | Apollo Scientific | MFCD31536741 | 170.187 | C8H11FN2O | 95.000 | CCNc1cc(F)ncc1CO | 250mg | 562446440
(4-(Ethylamino)-6-fluoropyridin-3-yl)methanol | Apollo Scientific | 2187435-45-4 | MFCD31536741 | 170.187 | C8H11FN2O | 95.000 | CCNc1cc(F)ncc1CO | 250mg | 562446440
Apexbio Technology LLC Coumarin 6 38215-36-0 50mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.87% | 453.94 | 100 MG
MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. It also acts as a weak agonist of PPARγ, with an IC50 of 2.5 μM, helping to alleviate hyperglycemia induced by PI3K inhibitors.
- Shows a concentration-dependent inhibitory effect on EGFR, P13K, and mTOR in CAL-33 cells.
- Activates PPARγ in 3T3-L1 cells.
- Inhibits EGFR and PI3K-mTOR pathway signaling in a time-dependent manner in mice.
- Suppresses tumor proliferation in mice.
- Shows excellent tolerance in mice and uniquely does not cause the hyperglycemia commonly seen with PI3K inhibitors.
- Enhances MEK inhibition in CRC.
- Combined with KRAS-G12C inhibitors, it suppresses tumor growth in mice with KRAS-G12C mutant colorectal cancer or pancreatic tumors.