Coumarins and derivatives
Medchemexpress LLC 6-Hydroxycoumarin | 6093-68-1 | 10 G
6-Hydroxycoumarin is a coumarin exhibiting diverse biological activities. It is noted for its anti-inflammatory, anti-pyretic, anti-oxidant, and vasodilator properties. This compound also demonstrates anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic, and antitumor activities.
- Demonstrates anti-inflammatory, anti-pyretic, and anti-oxidant activities
- Acts as a vasodilator, anti-amoebic, anti-bacterial, and anti-fungal agent
- Exhibits bacteriostatic and antitumor properties
- Appearance: light yellow to light brown solid
- Molecular formula: C9H6O3
- Molecular weight: 162.14
- Purity: 99.32%
- Melting point: 249-253 °C
- Boiling point: 248.82 °C at 760 mmHg
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) 7-hydroxy-2-oxochromene-3-carboxylate | 134471-24-2 | MFCD00037568 | >96.0% | 303.22 g/mol | C14H9NO7 | 10 MG
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is an N-hydroxysuccinimide (NHS)-activated fluorescent labeling reagent that introduces a 7-hydroxycoumarin fluorophore onto primary amines. Provided as a solid for research use, it is intended for bioconjugation and fluorescence-based assays.
- Reacts with primary amines via NHS ester chemistry for covalent labeling.
- Provides a blue/UV-excitable coumarin fluorophore suitable for protein, peptide, and nucleic acid labeling.
- Available in small-scale quantities convenient for analytical and preparative labeling.
- High chemical purity suitable for coupling reactions (suppliers report >96%).
- Stable when stored as directed; consult the product datasheet or certificate of analysis for storage and handling details.
Medchemexpress LLC 3-Hydroxycoumarin | 939-19-5 | 99.3% | 250 MG
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase, with an IC50 of 26 μM for recombinant human tyrosinase (rHT) and a Ki of 3.39 μM. It also demonstrates DPPH free radical scavenging activity (IC50 = 31.2 μM) and has photoprotective effects on sea urchin zygotes and embryos. This compound can be developed into a vesicle delivery system for local administration to achieve efficient local accumulation in the skin, facilitating the study of diseases related to excessive skin pigmentation.
- Acts as an inhibitor of tyrosinase and lipoxygenase
- Exhibits DPPH free radical scavenging activity
- Offers photoprotective effects on sea urchin zygotes and embryos
- Can be formulated into a vesicle delivery system for topical applications
- Effective in inhibiting the first cleavage of sea urchin embryos in a concentration-dependent manner
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 250 G
4-Hydroxycoumarin is an orally active coumarin derivative and a versatile heterocyclic scaffold used in the synthesis of various organic compounds. It exhibits both electrophilic and nucleophilic properties. It is identified as an HIV protease inhibitor and tyrosine kinase inhibitor, and also demonstrates anti-inflammatory, antibacterial, and anti-tumor effects.
- Acts as an HIV protease inhibitor
- Acts as a tyrosine kinase inhibitor
- Exhibits anti-inflammatory effects
- Exhibits antibacterial effects
- Exhibits anti-tumor effects
- Disrupts actin cytoskeleton in B16-F10 melanoma cells
- Reduces adhesion and motility to extracellular matrix proteins
- Inhibits tumor growth and improves survival rate in melanoma mice
- Reduces symptoms in a rat model of trinitrobenzene sulfonic acid-induced colitis
Sigma Aldrich Fine Chemicals Biosciences 7-Methoxycoumarin >=98% | 531-59-9 | MFCD00006876 | 25G
7-Methoxycoumarin >=98% | Purity: >=98% | Mol Wt: 176.17 | 531-59-9 | MFCD00006876 | 25G
