Flavonoids
Medchemexpress LLC Nicotiflorin | 17650-84-9 | 594.52 | 1 ML
Nicotiflorin is a flavonoid glycoside extracted from the traditional Chinese medicine *Carthamus tinctorius*. It exhibits potent antiglycation activity and neuroprotection effects.
- Flavonoid glycoside
- Extracted from Carthamus tinctorius
- Potent antiglycation activity
- Neuroprotection effects
- Attenuates cell death and reduces LDH release in cultured neurons
- Increases eNOS activity, mRNA, and protein levels in cultured rat cerebral blood vessel endothelial cells
- Reduces brain infarct volume and neurological deficits in rats following cerebral ischemia
Apexbio Technology LLC Icariin 489-32-7 100mg
Icariin (CAS 489-32-7) is a small-molecule inhibitor targeting phosphodiesterases notably PDE5 and PDE4 It is designed to modulate cyclic nucleotide signaling by inhibiting PDE activity thereby regulating processes such as smooth muscle relaxation and neuronal signaling Icariin exerts its biological activity primarily through the inhibition of PDE5 (IC 0 43 M) and PDE4 (IC 73 50 M) Based on these pharmacological properties icariin holds research potential in the investigation of erectile function nitric oxide synthase expression angiogenesis pathways and osteogenic differentiation in bone marrow stromal cells
Medchemexpress LLC Engeletin | 572-31-6 | 434.39 | 25 MG
Engeletin is a flavanonol glycoside isolated from *Smilax glabra Roxb.* It acts as an inhibitor of NF-κB signaling-pathway activation and exhibits various biological effects, including anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis properties. For research use only.
- Inhibits NF-κB signaling-pathway activation
- Possesses anti-inflammatory effects
- Offers analgesic properties
- Exhibits diuresis and detumescence effects
- Has antibiosis effects
Apexbio Technology LLC Naringin 10236-47-2 10g
Naringin (CAS 10236-47-2) is a flavanone glycoside predominantly isolated from the fruit of Citrus paradisi Macfadyen (grapefruit) It is recognized for modulating various cellular pathways including inhibition of oxidative stress and inflammation through interaction with NF- B and MAPK signaling cascades Naringin has demonstrated antioxidative anti-inflammatory and potential anti-carcinogenic properties in cellular and animal models Widely used in biomedical research it serves as a tool compound for investigating mechanisms underlying chronic diseases metabolic syndromes and the modulation of drug-metabolizing enzymes For optimal stability it should be stored in a tightly sealed container under cool dry conditions
AdipoGen Naringin (100 g)
Chemical. CAS: 10236-47-2. Formula: C27H32O14. MW: 580.54. Naringin is a citrus-derived flavonoid (bitter principal). It undergoes extensive metabolism in the liver. It has a broad panel of properties, including anti-inflammatory, antioxidant, anticancer, antidiabetic, cardioprotective, bone regenerative and neuroprotective activities. Naringin acts by modulating several signaling pathway targets, activity is primarily attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and inflammatory transcription factors) and antioxidant (via scavenging of free radicals, bolstering of endogenous antioxidant defense system and metal ion chelation) effects. It increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.
Medchemexpress LLC 5-Hydroxyflavone | 491-78-1 | 99.8% | 238.24 | 25 MG
5-Hydroxyflavone is a flavonoid ligand that shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells.
- Flavonoid ligand
- No cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells
- Solid, light yellow to yellow appearance
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC 6-Hydroxyflavone | 6665-83-4 | 1 ML
6-Hydroxyflavone is an orally effective flavonoid compound. It demonstrates anti-inflammatory effects by inhibiting LPS-induced NO production and promotes osteoblast differentiation by activating AKT, ERK 1/2, and JNK signaling pathways. Additionally, it offers kidney protective effects, inhibits bovine hemoglobin (BHb) glycosylation, and enhances GABA-induced current through specific GABAA receptor subtypes, contributing to an anti-anxiety role. For research use only.
- Orally effective flavonoid compound.
- Exhibits anti-inflammatory properties.
- Promotes osteoblast differentiation.
- Inhibits bovine hemoglobin (BHb) glycosylation.
- Offers kidney protective effects.
- Enhances GABA-induced current via specific GABAA receptors (anti-anxiety).
- Maintains cell viability at concentrations up to 50 μM.
- Tested in various cell-based and animal models.
Medchemexpress LLC Troxerutin | 7085-55-4 | 98.0% | 742.68 | 10 G
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins. It is capable of inhibiting the production of reactive oxygen species (ROS) and depressing ER stress-mediated NOD activation.
- Inhibits ROS production
- Depresses ER stress-mediated NOD activation
- Lowers body weight and improves metabolic parameters
- Restores glucose intolerance and insulin signaling
- Attenuates vascular damages
Medchemexpress LLC 5-Hydroxyflavone | 491-78-1 | 99.83% | 238.24 | 1 ML
5-Hydroxyflavone is a flavonoid ligand that exhibits no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells. It is intended for research use only.
- Available in solid and solution forms.
- Solid and solvent options available for reconstitution.
- Powder storage: -20°C for 3 years; 4°C for 2 years.
- In solvent storage: -80°C for 2 years; -20°C for 1 year.
- Soluble in DMSO.
Apexbio Technology LLC Troxerutin 7085-55-4 5g
Troxerutin (CAS 7085-55-4) is a bioactive small molecule known to exhibit protective effects against gamma radiation (GR)-induced DNA damage It promotes DNA repair mechanisms thereby reducing radiation-related single- and double-strand breaks Experimentally Troxerutin (1 mM) decreased GR-triggered micronucleus formation in human lymphocytes by approximately 41% In mouse models intraperitoneal administration before or after irradiation (up to 175 mg/kg) minimized micronucleus frequency in reticulocytes and mitigated DNA strand breaks in leukocytes and bone marrow cells with dosage-dependent results Its properties make Troxerutin relevant for radiation biology research particularly in genomic stability and radioprotection studies
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 10mM (in 1mL DMSO)
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Medchemexpress LLC 3,6-Dihydroxyflavone | 108238-41-1 | 10 MG
3,6-Dihydroxyflavone is an anti-cancer agent that dose- and time-dependently decreases cell viability and induces apoptosis by activating the caspase cascade and cleaving poly (ADP-ribose) polymerase (PARP). It also increases intracellular oxidative stress and lipid peroxidation.
- Anti-cancer agent
- Decreases cell viability
- Induces apoptosis by activating caspase cascade
- Cleaves poly (ADP-ribose) polymerase (PARP)
- Increases intracellular oxidative stress
- Increases lipid peroxidation
eMolecules 2196-14-7 | 7,4'-Dihydroxyflavone | MFCD00017694 | 1g
Ambeed | Naphthalen-1-ylmethanol | 25g | 525096950 | A179694 | 4780-79-4 | MFCD00004044 | 158.200 | C11H10O
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>