Flavonoids
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | MFCD00006835 | 50 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* that exhibits anti-inflammatory activity. It protects renal cells from nicotine-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This orally active compound also inhibits PKM2, COX-2, and 5-LOX, and has demonstrated antioxidant activity and efficacy in various animal models.
- Isolated from *Clerodendrum phlomidis*
- Exhibits anti-inflammatory activity
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2, COX-2, and 5-LOX
- Orally active
- Reduces malondialdehyde (MDA) and reactive oxygen species (ROS) levels
- Increases superoxide dismutase (SOD) and glutathione (GSH) levels
- Ameliorates ischemia/reperfusion injury
- Improves high-fat diet-induced non-alcoholic fatty liver disease and obesity
- Purity of 99.89%
- Appearance is a white to off-white solid
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 1 MG
Luteolin-7-rutinoside is a flavonoid glycoside exhibiting both anti-arthritic and antifungal activities. It can be used as a combination therapy for the treatment of fungal arthritis due to C. albicans infection. Its suppressive activity is dose-dependent, and it shifts the Th1-Th2 balance away from Th1- towards Th2-type responses, while also inhibiting nitric oxide (NO) production from macrophages.
- Anti-arthritic activity
- Antifungal activity
- Can be used for treatment of fungal arthritis due to C. albicans infection
- Suppressive activity on T cell proliferation is dose-dependent
- Shifts Th1-Th2 balance away from Th1- towards Th2-type responses
- Inhibits nitric oxide (NO) production from macrophages
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 50 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone, with potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
Medchemexpress LLC Fustin | 20725-03-5 | 1 MG
Fustin ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. It increases acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). It also decreases acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustin increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. It can be used for Alzheimer's disease research.
- Potent amyloid β (Aβ) inhibitor.
- Increases acetylcholine (ACh) levels and choline acetyltransferase (ChAT) activity.
- Decreases acetylcholinesterase (AChE) activity.
- Enhances muscarinic M1 receptor expression and binding.
- Suitable for Alzheimer's disease research.
Chem-Impex International, Inc. Quercetin | 117-39-5 | MFCD00006828 | 250G
Quercetin, 117-39-5, MFCD00006828, 250G
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.2. Synthetic. Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase 15-LOX inhibitor. IL-6 production inhibitor. Fatty acid synthase FAS inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 PDE1-5. PKCepsilon and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator Phosphatidylinositol 3-kinase PI3K / Akt signaling inhibitor. p90 ribosomal S6 kinase RSK1/RSK2 kinase activity inhibitor.
Indofine Chemical Myricetin With Hplc, 10 Mg
MYRICETIN with HPLC 10 MG, Flavone, 3,5,7,3',4',5'-Hexahydroxyflavone, Cannabiscetin, C15H10O8, MW: 318.25, 99% by HPLC, 529-44-2, MFCD00006827
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.24. Luteolin is a hydroxylated flavone derivative that is a strong antioxidant and radical scavenger. It has multiple activities, such as anticancer, antimetastatic, anti-adipogenic, anti-inflammatory and neuroprotective. Luteolin has been described as a fatty acid synthase FASN, 15-lipoxygenase, alpha-glucosidase, PPAR-gamma, topoisomerase I, PI3K/Akt, RSK1/RSK2 and HDAC inhibitor.
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 MG
Luteolin 7-O-glucuronide inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It also inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In a mouse sleep deprivation model, this compound improved depression-like and stress coping behaviors.
- Inhibits matrix metalloproteinases (MMPs) activities.
- Reduces NO production and inflammatory mediators.
- Inhibits NF-κB, p38, and JNK activation.
- Improves depression-like and stress coping behaviors.
- Suitable for in vitro and in vivo studies.
Sigma Aldrich Fine Chemicals Biosciences (−)-Epicatechin | 490-46-0 | MFCD00075648 | 5mg
(−)-Epicatechin | Purity: ≥98% | Mol Wt: 290.27 | 490-46-0 | MFCD00075648 | 5mg
Medchemexpress LLC Apigenin 7-O-glucuronide | 29741-09-1 | MFCD23699539 | >95.0% | 10 MG
Apigenin 7-O-glucuronide is a flavonoid glucuronide supplied as an analytical standard for research and analytical applications. It has reported inhibitory activity against matrix metalloproteinases, with IC50s of 12.87 μM (MMP-3), 22.39 μM (MMP-8), 17.52 μM (MMP-9), and 0.27 μM (MMP-13). CAS: 29741-09-1; molecular weight: 446.36 g/mol.
- Provided as a 10 mg analytical standard for research use only.
- Reported inhibitory activity against multiple MMP enzymes with published IC50 values.
- Chemical formula C21H18O11 and molecular weight 446.36 g/mol.
- Commonly used in biochemical and analytical assays to characterize apigenin metabolites.
Medchemexpress LLC Catechin | 154-23-4 | 290.27 | 5 MG
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- 15+ Cited publications
- Also known as (+)-Catechin; Cianidanol; Catechuic acid
- Targeting COX apoptosis, influenza virus, and endogenous metabolite pathways
- Research area: Cancer
- Structural classification: Anti-aging, Camellia sinensis (L.) O. Ktze. plants, endogenous metabolite, flavonoids, sunscreen, flavanols, phenols, polyphenols
- Application fields: Cosmetic research, disease research fields
- Source classification: Theaceae
Medchemexpress LLC Methyl-hesperidin | 11013-97-1 | 98.4% | 624.59 g/mol | C29H36O15 | 10 MG
Methyl-hesperidin is a flavonoid derivative used as an analytical standard and research reagent; it exhibits vasodilating activity and is provided for laboratory use.
- Purity: 98.39%.
- Cas number: 11013-97-1.
- Molecular weight: 624.59 g/mol.
- Molecular formula: C29H36O15.
- Supplied as a dry powder for analytical and in vitro applications.
- Available in small pack sizes including 10 mg.