Macrolide lactams
Apexbio Technology LLC FK 866 HCL 1ML DMSO
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC FK 866 HYDROCHLORIDE 50MG
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Selleck Chemical LLC FK-3311 S2595-5mg
FK-3311 (COX-2 Inhibitor V) is a selective cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory FK-3311 has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Selleck Chemical LLC Ascomycin
Ascomycin (FK520 FR 900520 Immunomycin) an FK-506 analog is a neutral macrolide immunosuppressant which prevents rejection after an organ transplant Phase 3
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
Abcam FK506 (Tacrolimus), Immunosuppressant, 10MG
MW 804 Da, Purity >98%. Immunosuppressant. Complexes with FKBP-12 to inhibit calcineurin. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC FK 866 HYDROCHLORIDE 25MG
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 100mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 200mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Sigma Organic Chemistry FK 209 Co(II) TFSI salt | 5G0.98
FK 209 Co(II) TFSI salt, 5G
About This Item:
UNSPSC Code: 12352103
Storage: room temp
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 500mg
Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies