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Macrolide lactams

Compounds that are analog of macrolides that contain lactam rings in place of lactone rings; they are a class of antibiotics. Lactam rings are nitrogen analogs of lactone rings.
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1

Tacrolimus Monohydrate 80.0+%, TCI America™

CAS: 109581-93-3 Molecular Formula: C44H71NO13 Molecular Weight (g/mol): 822.046 MDL Number: MFCD11045918 InChI Key: NWJQLQGQZSIBAF-MLAUYUEBSA-N Synonym: FK 506 PubChem CID: 5282315 ChEBI: CHEBI:61057 SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O

PubChem CID 5282315
CAS 109581-93-3
Molecular Weight (g/mol) 822.046
ChEBI CHEBI:61057
MDL Number MFCD11045918
SMILES CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O
Synonym FK 506
InChI Key NWJQLQGQZSIBAF-MLAUYUEBSA-N
Molecular Formula C44H71NO13
2

Sigma Aldrich Fine Chemicals Biosciences FK-506 monohydrate >=98% (HPLC) | 109581-93-3 | MFCD11045918 | 5MG

FK-506 monohydrate >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 | 5MG

ENCOMPASS
3

Medchemexpress LLC Fk-453 | 121524-18-3 | 99.2% | 375.46 g·mol⁻¹ | C23H25N3O2 | 100 MG
SDP

FK 453 is a potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM) supplied as a high-purity small-molecule powder for research use. It includes recommended storage and solvent handling guidance to support reproducible in vitro assays.

  • High purity 99.2%.
  • Potent adenosine A1 receptor antagonist, IC50 17.2 nM.
  • Molecular weight 375.46 g·mol⁻¹; formula C23H25N3O2.
  • Recommended solvent DMSO at 100 mg/mL; may require ultrasonication.
  • Storage: powder -20°C (up to 3 years), 4°C (up to 2 years); in solvent -80°C (6 months), -20°C (1 month).
  • Suitable for in vitro pharmacology and receptor binding studies.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Tacrolimus | 104987-11-3 | MFCD00869853 | 99.6% | C44H69NO12 | 10MG
SDP

Tacrolimus (Standard) is an analytical reference standard of tacrolimus (FK506) intended for research and analytical laboratories. It is used for calibration, method development, and qualitative or quantitative analyses by techniques such as HPLC, GC, and mass spectrometry, and is supplied with supporting documentation for analytical use.

  • High purity (99.6%) suitable for trace-level quantitation.
  • Compatible with HPLC, GC, and MS analytical methods.
  • Supplied as an analytical standard for calibration and method development.
  • Certificate of analysis and safety data sheet available.
  • Available in multiple small pack sizes for analytical workflows.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Tacrolimus (Standard) | 104987-11-3 | 99.6% | 804.02 | 50 MG
SDP

Tacrolimus (Standard) is the analytical standard of Tacrolimus, intended for research and analytical applications. It functions as a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which then inhibits T-lymphocyte signal transduction and IL-2 transcription, ultimately possessing immunosuppressive properties. It is suitable for a variety of research assays and experiments.

  • Analytical standard grade
  • Reference standard for assays
  • Used in qualitative, quantitative, and methodological research experiments
  • Compatible with techniques such as HPLC, GC, and MS

ENCOMPASS_PREFERRED
6

Medchemexpress LLC (E/Z)-FK-506 26,28-allylic ester rearrangement impurity | 131944-48-4 | 804.02 | C44H69NO12 | 5 MG
SDP

(E/Z)-FK-506 26,28-allylic ester rearrangement impurity (FK506-A) is an impurity of tacrolimus supplied as a reference substance for analytical and research applications. It is intended for use in impurity identification, method development, and stability studies where characterization of tacrolimus-related degradation or synthesis by-products is required.

  • Provides a characterized impurity reference for analytical validation.
  • Enables impurity profiling and stability testing of tacrolimus samples.
  • Compatible with HPLC and LC-MS analytical workflows.
  • Offered in small milligram quantities suitable for method development.
  • Includes CAS and molecular data to support documentation.

ENCOMPASS_PREFERRED
7

Medchemexpress LLC (+)-(R)-[(E)-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-piperidineethanol | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 50 MG
SDP

FK 453 is a non-xanthine adenosine A1 receptor antagonist (compound 1d) used in pharmacological research. It is reported as potent and selective, with an IC50 of 17.2 nM. The compound has chemical formula C23H25N3O2, molecular weight 375.46, and reported purity 99.20%.

  • Potent and selective A1 receptor antagonist (IC50 17.2 nM).
  • High reported purity suitable for research use (99.2%).
  • Chemical formula C23H25N3O2 and molecular weight 375.46.
  • Available in small research quantities, for example 50 mg.
  • Supplied with supporting analytical data such as COA, HPLC, and LCMS.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC Tacrolimus (standard) | 104987-11-3 | 99.6% | 804.02 | 25 MG
SDP

Tacrolimus (Standard) is the analytical standard of Tacrolimus, intended for research and analytical applications. This macrocyclic lactone binds to FK506 binding protein (FKBP) to form a complex, inhibiting calcineurin phosphatase, T-lymphocyte signal transduction, and IL-2 transcription, thereby exhibiting immunosuppressive properties.

  • Analytical standard for research and analytical applications.
  • Binds to FKBP and inhibits calcineurin phosphatase.
  • Inhibits T-lymphocyte signal transduction and IL-2 transcription.
  • Exhibits immunosuppressive properties.
  • Used as a reference standard in assays.
  • Suitable for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.

ENCOMPASS_PREFERRED
9

Medchemexpress LLC Tacrolimus (Standard) | 104987-11-3 | 99.6% | 804.02 | 100 MG
SDP

Tacrolimus (Standard) is an analytical standard intended for research and analytical applications. This macrocyclic lactone binds to FK506 binding protein (FKBP) to form a complex. It inhibits calcineurin phosphatase, which in turn inhibits T-lymphocyte signal transduction and IL-2 transcription, possessing immunosuppressive properties.

  • Analytical standard for research and analytical applications
  • Used in qualitative research experiments
  • Used in quantitative research experiments
  • Used in methodological research experiments
  • Suitable for HPLC, GC, and MS applications
  • Inhibits calcineurin phosphatase
  • Inhibits T-lymphocyte signal transduction and IL-2 transcription
  • Possesses immunosuppressive properties

ENCOMPASS_PREFERRED
10

Medchemexpress LLC FK 453 | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 25 MG
SDP

FK 453 is a research-use adenosine A1 receptor antagonist (compound 1d) characterized by potent activity and a defined chemical profile. It exhibits an IC50 of 17.2 nM and is supplied as a high-purity powder with recommended storage conditions for both powder and solution forms.

  • Potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM).
  • High purity: 99.2%.
  • Molecular formula C23H25N3O2 and molecular weight 375.46.
  • Available in multiple small-scale package sizes, including 25 mg.
  • Storage recommended as powder at -20°C (3 years) or 4°C (2 years).
  • In solvent storage guidance: -80°C (6 months) or -20°C (1 month).
  • For research use only; not for human or clinical use.

ENCOMPASS_PREFERRED
11

Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 10 MG
SDP

FK 453 is a potent, selective adenosine A1 receptor antagonist intended for research use. It inhibits human A1 receptor activity with an IC50 of 17.2 nM, appears as an off-white to light yellow solid, and also shows activity at adenosine A2B and in primary rat hepatocytes.

  • Potent adenosine A1 receptor antagonist (IC50 17.2 nM).
  • Additional activity at adenosine A2B (cAMP accumulation IC50 0.98 μM).
  • Inhibits NECA-induced glucose production in primary rat hepatocytes (IC50 8.1 μM).
  • High purity: 99.2%.
  • Molecular weight: 375.46.
  • Off-white to light yellow solid; soluble in DMSO (100 mg/mL).
  • Storage recommendations: powder -20°C (3 years); in solvent -80°C (6 months).

ENCOMPASS_PREFERRED